Navigation Links
Does natural selection drive the evolution of cancer?

population. When mutant tumor cells divide to replicate, the daughter cells share the same mutations.

The final condition is that the variation has to affect fitness, the survival and reproduction of the cells. All of the characteristics that are considered hallmarks of cancer affect fitness, according to Maley. Among these are that cancer cells no longer heed normal growth inhibition signals in their environment, they no longer require an external signal to divide as healthy cells do, and they are able to suppress a vital set of internal instructions that require cells to self-destruct when their genes are mutated beyond repair. This protective cell-suicide program carried by normal cells is known as apoptosis.

Seeing a tumor in this light opens a window on new therapeutic strategies.

"It's not just a metaphor to say tumor cell populations are evolving," Maley says. "Evolution is going on in the tumor. So let's think about how we might want to influence that evolution. Can we push it down paths that might be more beneficial to us?"

One idea might be to develop new drugs that would act as benign cell boosters. Such drugs would specifically target the more benign cells in a tumor to increase their relative fitness over their malignant neighbors. This would allow the benign cells to outcompete the malignant cells, leading to a less aggressive, less dangerous tumor.

"Another idea we're pursuing is what we call the sucker's gambit," Maley says. "In this case, you try to increase the fitness of chemosensitive cells so that they outcompete any resistant cells that are in the tumor. And then you apply your chemotherapy. So you sucker the tumor into a vulnerable state and then you hit it with your therapy."

In their review, Maley and his coauthors also explored how the ecological ideas of competition, predation, parasitism, and mutualism unfold in tumors. Here again, they found that the concepts from another field
'"/>

Source:The Wistar Institute


Page: 1 2 3

Related biology news :

1. Genetically modified natural killer immune cells attack, kill leukemia cells
2. UCSD discovery may help extend life of natural pesticide
3. Insight into natural cholesterol control suggests novel cholesterol-lowering therapy
4. UCLA scientists store materials in cells natural vaults
5. Man-made wetlands effectiveness similar to natural marsh
6. Researchers pioneer new gene therapy technique using natural repair process
7. Tsunami-damaged coral reefs should be left to recover naturally, say scientists
8. Cornell finds natural selection in humans
9. Oysters: The natural way to protect our shores
10. New discovery: Molecular variation in one gene affects the growth of natural populations
11. Common bacteria pirate natural mechanism to get inside cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Does natural selection drive the evolution cancer

(Date:7/9/2014)... Rochelle, NY, July 9, 2014Biofuels derived from the oils ... to fossil fuels. To achieve this goal, optimization of ... in open pond systems, is needed. Sapphire Energy has ... of open pond algae cultivation systems, described in ... Liebert, Inc., publishers. The article is available on the ...
(Date:7/9/2014)... of Guelph scientist that involved fitting bumblebees with ... a neonicotinoid pesticide hampers bees, ability to forage ... a professor in Guelph,s School of Environmental Sciences, ... published July 9 in the British Ecological Society,s ... shows how long-term pesticide exposure affects individual bees, ...
(Date:7/9/2014)... study shows that some shark species may be able to ... come with rising temperatures. , The Arctic today is best ... wasn,t always like that. Roughly 53 to 38 million years ... Arctic was more similar to a huge temperate forest with ... ancestors of tapirs, hippo-like creatures, crocodiles and giant tortoises. Much ...
Breaking Biology News(10 mins):Controlling contamination in open algae ponds for biofuels 2Bee foraging chronically impaired by pesticide exposure: Study 2Shark teeth analysis provides detailed new look at Arctic climate change 2Shark teeth analysis provides detailed new look at Arctic climate change 3
... BUFFALO, N.Y. -- Among the many differences between girls ... and subjective -- to the list. , Results of a ... caffeine found that, in general, boys get a greater rush ... reported they felt that caffeine had a positive effect on ...
... Professor Dr. Michael Ristow,s team along with Japanese colleagues ... two independent approaches that even a low concentration of ... as well as in a model organism, the roundworm ... results in the online edition of the scientific publication ...
... is a growing concern. Protected areas are a instrument to ... of the parties in Nagoya (October 2010) set stringent new ... terrestrial and inland water and 10% of coastal and marine ... protected? Are they in the right place? Where should new ...
Cached Biology News:High-caffeine-consuming boys get greater rush from caffeine than girls 2High-caffeine-consuming boys get greater rush from caffeine than girls 3Fountain of youth from the tap 2Biodiversity in danger: Which areas should be protected? 2Biodiversity in danger: Which areas should be protected? 3
(Date:1/14/2014)... (PRWEB) January 14, 2014 iLab Solutions, the ... as the new Director of Product Strategy. In this role, ... as iLab sub-teams to guide in the development of iLab ... provides the maximum possible benefit to the scientific community by ...
(Date:1/14/2014)... MD (PRWEB) January 14, 2014 ... to developing innovative information technology solutions for patients, ... health care stakeholders, announced today the signing of ... US Food and Drug Administration (FDA). This ...
(Date:1/14/2014)... Orange, CA (PRWEB) January 14, 2014 Kerr ... a 10-minute video and additional how-to information about dual arch ... Great Restorations with Dual Arch Impressions,” the blog entry serves ... the technique and houses a step-by-step demonstration by Dr. David ...
(Date:1/14/2014)... BioMedomics, Inc. , a Point of Care ... novel disease specific POC tests, announced today that it has ... of $690,000. The investment is from private investors and is ... of private investors has significant successful experience in early investments ...
Breaking Biology Technology:iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2BioMedomics, Inc. Closes $690K Round of Financing 2
... , , , , , ... , of 139 human cancer-related genes for functional genomics research ... , , , , , ... leading academic , cancer researchers (see table below for a ...
... , , For 124 high-purity plasmid minipreps , , , ... , , , ... , Purification module: , QIAprep spin columns, ... 124 samples, , , ...
... , , , , , , For purification of ... Classic QIAGEN Plasmid Kits use gravity-flow anion-exchange tips for efficient , purification of plasmid DNA ... Features and benefits , ... Purity equivalent to that obtained by 2x CsCl-gradient centrifugation , ...
Cached Biology Technology:Cancer siRNA Oligo Set Version 1.0 2Cancer siRNA Oligo Set Version 1.0 3Cancer siRNA Oligo Set Version 1.0 4
Recombinant DNA polymerase from Thermus aquaticus expressed in E. coli; 5 units/L; 1 tube of 1, 000 units enzyme/tube w/Buffer II and MgCl2...
Taq DNA Polymerase (T. aquaticus), 4 x 250 units. For PCR and other procedures requiring DNA polymerase activity at elevated temperatures. Category: Nucleotides & Enzymes & Biochemicals, Modifying En...
... Gold® DNA Polymerase is a chemically modified ... chemical moiety is attached to the enzyme, ... the first ramp of thermal cycling (when ... temperatures), the enzyme is inactive. The result ...
Taq DNA Polymerase (cloned), 250 units. Category: Nucleotides & Enzymes & Biochemicals, Modifying Enzymes, Polymerases....
Biology Products: