Navigation Links
Doctors closer to using gene analysis to help trauma patients

A genetic tool with the potential to identify which trauma and burn patients are most likely to become seriously ill has worked consistently in a wide range of experimental clinical settings ?an important hurdle to overcome before the method is routinely used in emergency rooms and intensive care units.

In a report published today (March 7) in the Proceedings of the National Academy of Sciences, researchers from eight institutions, including the University of Florida, describe how they were able to consistently analyze which genes are active in patients with serious infections or traumatic injuries.

Researchers want to understand the genetic features that enhance a patient’s recovery as well as the elements that cause people to die sometimes weeks after an injury occurs. Identifying those factors could help physicians choose the best treatment, a decision that could mean the difference between life and death, according to UF Genetics Institute scientists.

“The vast majority of patients who experience severe trauma or burn injuries actually do well,?said Lyle Moldawer, a surgery professor in UF’s College of Medicine. “They’re resuscitated at the scene, taken to the hospital, have an uneventful recovery and they’re discharged. But there’s a certain fraction who go on to develop complications that lead to organ failure and death, which is the most common cause of death after traumatic injury ?sepsis and multisystem organ failure. So the goal is to use functional genomics as a tool to identify those patients who, after severe trauma and burn injury, will go on to manifest this multisystem organ failure. It’s a way to better characterize the nature of the immuno-inflammatory response to trauma.?/p>

Dr. Ronald G. Tompkins, a surgeon and biomedical engineer at Massachusetts General Hospital, is leading the effort to develop standard operating procedures for the care of burn and trauma patients and increase understanding of the body’s molecular re actions to injury, including inflammation. The lead research author is Dr. J. Perren Cobb, an associate professor of surgery at Washington University in St. Louis.

Traumatic injuries claim hundreds of thousands of lives each year in the United States. In addition, millions of patients are hospitalized, at an annual cost to society of more than $200 billion. Patients may face a long and difficult recovery period riddled with many potentially fatal complications along the way.

“What we have shown is medical professionals can collect blood and tissue samples from patients, process them at different institutions and get consistent results,?said Henry Baker, associate director of the UF Genetics Institute and interim chairman of molecular genetics and microbiology. “For any tool used in clinical medicine, it’s important that people are able to get the same answers wherever the tool is being used.?/p>

Genomic analyses took place at UF, the Stanford Genome Technology Center and Washington University in St. Louis. Overall data analysis was based at Massachusetts General Hospital at Harvard Medical School.

Specially trained clinical personnel sampled whole blood and other available tissues from more than 200 severely traumatized or burned patients and 23 healthy individuals in an effort to correlate molecular markers with white blood cell behavior, and ultimately, with patient outcome. Studies in healthy patients were conducted at UF, Washington University in St. Louis, the University of Rochester School of Medicine and the University of Medicine and Dentistry of New Jersey. Patients with severe traumatic injuries were studied at the University of Washington at Seattle and the University of Rochester.

In the end, scientists could see dramatic changes in genes turning on and off in trauma victims compared with healthy people. Among the trauma patients, researchers say “analytical noise??differences attributable to the testing method ?was no t significant, suggesting that profiling gene reactions may provide meaningful information to doctors.

The next step is for scientists to continue the experimental procedures in larger multicenter trials, following hundreds of patients over time to describe the molecular profile of healing in response to burns and traumatic injury, researchers say.


'"/>

Source:University of Florida


Related biology news :

1. Doctors should stop prescribing antibiotics for the common cold, review advises
2. New Discovery May Help Doctors Treat Infertility
3. Chemicals in tattoo inks need closer scrutiny
4. Proteomics brings researchers closer to understanding microbes that produce acid mine drainage
5. Scientists closer to new cancer detection method
6. Stroke treatment a step closer after trial
7. Sperm stem cells closer to being like embryonic stem cells
8. Scientists a step closer to protecting worlds most important crop
9. Scientists one step closer to cancer vaccine
10. UC Davis researchers move biotechnology closer to replacing electronic pacemakers
11. Producing bio-ethanol from agricultural waste a step closer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/6/2017)... Jan. 5, 2017  Delta ID Inc., a leader ... technology for automotive at CES® 2017. Delta ID has ... to demonstrate the use of iris scanning as a ... the driver in a car, and as a way ... experience. Delta ID and Gentex will demonstrate ...
(Date:12/22/2016)... MOUNTAIN VIEW, Calif. , Dec. 20, 2016  As ... all levels, 23andMe, the leading personal genetics company, recently released ... Only Me . The book focuses on the topics ... the Next Generation Science Standards (NGSS) taught in elementary school ... the second in a series by illustrator Ariana Killoran ...
(Date:12/19/2016)... TORONTO , 19 de diciembre de 2016  Mosaic ... permitirá el desarrollo acelerado de MSC-1, un anticuerpo humanizado que se ... tumor en 2017, con múltiples sitios previstos a lo largo de ... ... el factor inhibidor de leucemia (LIF), una citoquina pleiotrópica que se ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... BETHESDA, Md. , Jan. 18, 2017  Northwest ... company developing DCVax® personalized immune therapies for operable and ... Marnix Bosch , Chief Technical Officer of NW Bio, ... Thursday, January 19, 2017, at the Hyatt Regency Hotel ... Dr. Bosch will chair the session entitled "New Therapeutic ...
(Date:1/19/2017)... LAKES, N.J. , Jan. 18, 2017 BD (Becton, ... technology company, announced today that it will host a live webcast ... at 1 p.m. (ET). The webcast can be ... be available for replay through Tuesday, January 31, 2017. ... About BD BD ...
(Date:1/18/2017)... According to a new market research report "In situ Hybridization Market by ... (Molecular Diagnostic Laboratories, Academic and Research Institutions) - Global Forecast to 2021" published ... from USD 557.1 Million in 2016, growing at a CAGR of 5.8%. ... ... MarketsandMarkets Logo ...
(Date:1/18/2017)... Mass. , Jan. 18, 2017 ... applying mechanistic modeling to drug research and development, ... PhD, Co-Founder, President, and CEO of Applied BioMath, ... for Informatics and Modeling (BAGIM) Meeting on Thursday ... Cambridge , MA.   Dr. Burke,s ...
Breaking Biology Technology: