Navigation Links
Distinguishing friend from foe in the battle against cancer

ctive Hunter and Verma labs moved those mouse studies to the next level by tinkering with TSC activity in human cancer cells. Says Ghosh, "We were able to extend this model based on TSC null cells to different human cancer cell lines, where we knocked down TSC expression and showed that the same pattern held true."

Specifically, the team found that human cells lacking TSC genes were vulnerable to chemotherapeutic attack because they couldn't activate a major line of defense mediated by the Nuclear Factor kappa B, known as NF-kB, which triggers both inflammatory and survival responses by inducing transcription of specific genes.

Not only did this explain why TSC null cells are vulnerable to insult, but it also provided biochemical evidence that there is crosstalk between two survival mechanisms. Explains Tergaonkar, who is now an assistant professor at the Institute for Molecular and Cell Biology (IMCB) in Singapore, "Our findings show for the first time that the TSC complex can regulate the NF-kB signaling cascade."

The experiments also explained a paradox: TSC null cells treated with rapamycin actually survived cellular insult better than untreated cells-a highly inauspicious outcome if the goal is to kill cancer cells. The Hunter and Verma team found that rapamycin did that by increasing NF-kB activity in the TSC null cells when they were exposed to chemotherapeutic drugs.

Rapamycin, an immunosuppressant used to block organ rejection after transplants, also inactivates proteins stimulating cell division and in clinical trials has been combined with other drugs to halt cancer cell growth.

But to cancer cells, rapamycin is both friend and foe. "Rapamycin is not as successful as initially expected in treating cancer," explains Ghosh. "Instead of killing cells, you end up triggering a survival response in them." This study, however, suggests that taking NF-kB out of the game would make rapamycin less "friendly."

"A maj
'"/>

Source:Salk Institute


Page: 1 2 3

Related biology news :

1. W.M. Keck Foundation funds study of friendly microbes
2. Plants respond similarly to signals from friends, enemies
3. Grass makes environmentally friendly biofuel
4. Plant pathologists evaluate eco-friendly alternatives to methyl bromide
5. FDA approves child-friendly AIDS medicine
6. Mans best friend: Study shows lonely seniors prefer playtime with pooch over human interaction
7. Eco-friendly bug sucker
8. Surprising symbiosis: Glassy-winged sharpshooter eats with friends
9. Train your brain to hear your friends at a party
10. Mans best friend lends insight into human evolution
11. UN environmental agency steps up battle against marine pollution
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Distinguishing friend from foe the battle against cancer

(Date:11/4/2014)... newly published research study examining only marketing directed ... fast food restaurants has found that the majority ... exposed to such marketing tactics. , Authored by ... colleagues, the study is the first to examine ... and exterior of fast food restaurants and its ...
(Date:11/4/2014)... VILNIUS, Lithuania , Nov. 4, 2014 /PRNewswire/ ... identification technologies, today announced that the latest version ... place in the Ongoing MINEX evaluation ... interoperability of fingerprint algorithms using the INCITS 378 ... a mandatory requirement in public tenders in ...
(Date:11/3/2014)... 2014  NeuroSigma ® , Inc. (NeuroSigma), a ... focused on commercialization of its non-invasive ... of neurological and neuropsychiatric disorders, announced today that ... a Notice of Allowance for Mexican Patent Application ... NeuroSigma and the Regents of the University of ...
Breaking Biology News(10 mins):Fast food marketing for children disproportionately affects certain communities 2Fast food marketing for children disproportionately affects certain communities 3Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 3NeuroSigma Receives Notice of Allowance from the Mexican Institute of Industrial Property Covering Subcutaneous Trigeminal Nerve Stimulation (sTNS) 2NeuroSigma Receives Notice of Allowance from the Mexican Institute of Industrial Property Covering Subcutaneous Trigeminal Nerve Stimulation (sTNS) 3
... (UK) are to investigate how lethal viruses attack differently sized ... the door to new methods of pest control. The project, ... grain-infesting Indian meal moth ( Plodia interpunctella ) and a ... and sometimes not. Dr Steve Sait from the University ...
... Virginia Tech released today the results of a new rating ... the risk of concussions. One currently manufactured helmet received ... helmets received the very good "4-star" rating. ... first time researchers have provided the public with comparative test ...
... Palo Alto, CA Accurately calculating the amount of ... bringing products to our doorsteps is nearly impossible, but ... a commentary published online this week by Proceedings of ... Ken Caldeira and Steven Davis commend the work of ...
Cached Biology News:No safety in numbers for moths and butterflies 2Virginia Tech announces football helmet ratings for reducing concussion risk 2Virginia Tech announces football helmet ratings for reducing concussion risk 3Virginia Tech announces football helmet ratings for reducing concussion risk 4Consumption, carbon emissions and international trade 2
(Date:11/26/2014)... The announced sales of three healthcare units ... to expand in non-healthcare areas, says Kalorama Information. Siemens ... firm says that  Siemens is the third largest company ... the IVD market , with 5.5 billion in IVD ... would likely affect IVD market shares.  ...
(Date:11/26/2014)... MD (PRWEB) November 26, 2014 On ... invite the Baltimore and Washington D.C. science community to ... , The event, sponsored by the Protein Society, will ... UMBC’s University Center, Room 312. Through discussion, presentations ... and structural importance of proteins, their role in the ...
(Date:11/26/2014)... Morristown, NJ (PRWEB) November 25, 2014 ... it has officially joined the Morris County (New ... MCCC, which is a leading business organization in ... unique opportunity to further engage some key clients ... have operations in the geographic area. Membership enables ...
(Date:11/26/2014)... Continuing its award-winning streak, Nerium International, the ... Awards for outstanding creative achievement by its marketing and ... the organization’s top honor, in the Branding category for ... April of this year. The event showcased top speakers ... was awarded a Gold MarCom Award in the Special ...
Breaking Biology Technology:Kalorama: Sale of Three Siemens Healthcare Units Raises Questions About Firm's IVD Future 2Whitehouse Laboratories Joins Morris County Chamber of Commerce 2Whitehouse Laboratories Joins Morris County Chamber of Commerce 3Nerium International™ Wins One Platinum, Two Gold MarCom Awards 2
... 2009 , , ARVADA, Colo., June 16 ... and responsibility to our shareholders, is addressing our recent ... Finance 2009, a Biotechnology, Medical Devices, and world public ... 4-5. , , Pharma Finance is an international ...
... Sunesis Pharmaceuticals, Inc. (Nasdaq: SNSS ), a ... oncology therapeutics for the treatment of solid and hematologic cancers, ... will be presenting at the Jefferies 3rd Annual Healthcare Conference ... 17, 2009. , , The live webcast of this ...
... SHANGHAI, June 16 /PRNewswire-Asia/ -- Sundia MediTech Company, a,Shanghai-based ... facility in Shanghai has passed the audit from a ... are praised,for providing good facilities and programs for the ... The inspection and audit took place in May. ...
Cached Biology Technology:GeneThera Extends its Reach Overseas 2Sundia's Animal Facility Passed Client and Government Inspection 2
... , Coated Capture Antibody: 12 x 8-well strips, ... mL of 2X concentrate , Beta Amyloid ... , Lyophilized Standard Diluent: 3 mL , Primary ... Antibody-HRP: 30 microL of concentrate , OPD Substrate: ...
Human Cell Line Slides...
Request Info...
HSV 1 IgM...
Biology Products: