Navigation Links
Dissecting the machinery of nicotine's reward

Understanding what makes people crave the high of nicotine is a key to developing treatment for this highly addictive drug. And that understanding involves tracing the neural machinery by which nicotine switches on the brain's reward machinery.

In an article in the June 15, 2006, Neuron, Jean-Pierre Changeux of CNRS, Collège de France, and Institut Pasteur and Philippe Faure of Institut Pasteur and CNRS and colleagues revealed key details of how nicotine stimulates neurons that are an integral part of the reward circuitry. They also found that the same circuitry is involved in triggering exploratory and novelty-seeking behaviors. Their findings bring us a step closer to understanding regulation of that circuitry, information that is, as the researchers write, "crucial to understand the mechanisms responsible for the vulnerability to drugs of abuse."

In their experiments, the researchers sought to understand how nicotine stimulates particular receptors--called nicotinic acetylcholine receptors (nAChRs)--on the surface of neurons that produce the neurotransmitter dopamine. Such "dopaminergic" neurons are known to be central to turning on the brain's reward mechanism. The stimulation of nAChRs by nicotine makes them more responsive to their natural triggering neurotransmitter, acetylcholine (ACh).

Receptors such as nAChRs are complex proteins that nestle in the surface of cells and trigger cellular responses when activated by either a natural chemical or an external substance such as nicotine. Researchers studying the structure of nAChRs had found that they comprise many components called subunits that influence the receptors' function. In particular, two subunits called ß2 and a7 had been implicated as important in nAChRs' response to nicotine.

Changeux and colleagues tested in mice how dopamine-producing neurons responded to nicotine when the researchers genetically removed either of these subunits. They found that dopaminergic neurons
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Scientists take aim at virulent bacteria by decoding machinery of key control enzyme
2. Gambling monkeys give insight into neural machinery of risk
3. Clearing jams in copy machinery
4. New insight into machinery of immune cells tentacles
5. Biologists probe the machinery of cellular protein factories
6. Revealing the machinery underlying the plastic juvenile brain
7. New research identifies gene important for nicotines effects on the brain
8. Mechanism of nicotines learning effects explored
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Dissecting the machinery nicotine reward

(Date:8/29/2014)... the Tibetan plateau -- the largest topographic anomaly above ... its profound effect on climate and its reflection of ... Bulletin , Katharine Huntington and colleagues employ a cutting-edge ... and fossil snail shells to investigate the uplift history ... Views range widely on the timing of surface uplift ...
(Date:8/28/2014)... German . The ... a striking pattern of blue stripes alternating with golden stripes. ... and yellow cells emerge during growth in the skin of ... to compose the characteristic colour pattern. ,While it ... to form proper stripes, the embryonic origin of the pigment ...
(Date:8/28/2014)... (Maximizing Access to Research Careers) Program has announced ... of America,s 27th Annual Mouse Molecular Genetics Conference ... Pacific Grove, California. These awards are meant ... and scientists from underrepresented groups into the mainstream ... the participation of young scientists at the Genetics ...
Breaking Biology News(10 mins):Snails tell of the rise and fall of the Tibetan Plateau 2Snails tell of the rise and fall of the Tibetan Plateau 3Snails tell of the rise and fall of the Tibetan Plateau 4Snails tell of the rise and fall of the Tibetan Plateau 5Snails tell of the rise and fall of the Tibetan Plateau 6Snails tell of the rise and fall of the Tibetan Plateau 7How the zebrafish gets its stripes 2How the zebrafish gets its stripes 3
... identified new molecular components of the machinery that regulates ... T cells grasp other cells. This embrace by such ... communication with cells called "antigen presenting cells" (APCs). Such ... target invading microbes for destruction. Antigens are proteins in ...
... has destroyed 17 percent of the native vegetation in ... new study published by Conservation International sounds an alarm ... Continued deforestation at the current rate would cause all ... years, according to CI researchers in Brazil. , Overall, ...
... anti-microbial treatment that adheres to the skin without being ... Spirit, a burned dog in a high-profile animal cruelty ... Aquarium in Atlanta. , The researchers envision a ... to patent. , Dr. Bran Ritchie, a distinguished ...
Cached Biology News:New insight into machinery of immune cells' 'tentacles' 2New insight into machinery of immune cells' 'tentacles' 3Report shows deforestation threatens Brazil's Pantanal 2New antimicrobial compound adheres to skin to promote healing 2
(Date:8/28/2014)... Best Sanitizers, Inc., a leader in hand ... is asking industry professionals to prepare for fall harvest ... soap they’re currently using to the Best Sanitizers’ ... hygiene is critical to fighting cross-contamination and the spread ... criteria are identified to evaluate the effectiveness of an ...
(Date:8/28/2014)... Aug. 28, 2014 ... market research report is available ... Whole Exome Sequencing Market by ... Target Enrichment), by Services (Sequencing), ... by Application (Cancer, Monogenic disorders) ...
(Date:8/28/2014)... Aug. 28, 2014  Armetheon, Inc. ( www.armetheon.com ... mid- to late-stage cardiovascular drug candidates, today announced ... first round of financing. The Series A round ... Bioventures with participation from investors that included Atheneos ... Dr. Larry Hsu , the founder of ...
(Date:8/28/2014)... August 28, 2014 PrimeSource Building ... materials, selected SoundConnect to support their ... based audio and web conferencing platform GlobalMeet powered ... PrimeSource’s employees’ needs. SoundConnect delivers award winning ... PrimeSource Building Products will be utilizing GlobalMeet ...
Breaking Biology Technology:Best Sanitizers, Inc. Asks Food Industry Professionals: With Fall Harvest On the Way, Is Your E2 Hand Soap Up to the Task? 2Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 2Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 3Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 4Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 5Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 6Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 7Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 8Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 9Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 10Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 11Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 12Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 13Armetheon Completes $7.0 Million Series A Financing 2Armetheon Completes $7.0 Million Series A Financing 3PrimeSource Chooses SoundConnect as Collaboration Provider 2
... 19, 2011 Quanterix Corporation, a company enabling a ... revolutionary Si ngle Mo lecule A ... a pilot study to measure biomarkers of inflammation from ... low abundance cytokines, which was possible using Quanterix,s high ...
... Amgen (NASDAQ: AMGN ) today announced that ... eight year efficacy and safety data from a Phase 2 ... mineral density (BMD), at the 2011 American Society for Bone ... from Sept. 16-20, 2011. "The breadth of data ...
... NEW YORK, Aug. 18, 2011 Reportlinker.com ... is available in its catalogue: ... http://www.reportlinker.com/p0588171/Global-Genetic-Testing-Market-Analysis.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Genomics ... genetic testing represents a highly attractive segment. ...
Cached Biology Technology:Quanterix Digital ELISA Measures Low Abundance Biomarkers of Inflammation in Crohn's Disease 2Amgen Highlights Data to Be Presented at American Society for Bone and Mineral Research Meeting 2Amgen Highlights Data to Be Presented at American Society for Bone and Mineral Research Meeting 3Amgen Highlights Data to Be Presented at American Society for Bone and Mineral Research Meeting 4Amgen Highlights Data to Be Presented at American Society for Bone and Mineral Research Meeting 5Amgen Highlights Data to Be Presented at American Society for Bone and Mineral Research Meeting 6Amgen Highlights Data to Be Presented at American Society for Bone and Mineral Research Meeting 7Amgen Highlights Data to Be Presented at American Society for Bone and Mineral Research Meeting 8Amgen Highlights Data to Be Presented at American Society for Bone and Mineral Research Meeting 9Amgen Highlights Data to Be Presented at American Society for Bone and Mineral Research Meeting 10Amgen Highlights Data to Be Presented at American Society for Bone and Mineral Research Meeting 11Global Genetic Testing Market Analysis 2Global Genetic Testing Market Analysis 3
... PULSin may be superior to transfection in ... transfection, with PULSin you can study lethal ... course of proteins in cells. Likewise, delivery ... than traditional RNA interference experiments. ,With ...
... with a thin silicon strain chamber to ... fluorescence microscopy. Biaxial strain that is experienced ... be simulated by mechanical stretching or compression ... our strain chamber. Strain can be applied ...
... The versatile ST-195 allows real-time observations ... conditions. This instrument has 64 different strain ... CO2 incubator. The thin silicon strain chamber ... inverted microscopes and fluorescence microscopy. ST-195 can ...
Immunogen GST fusion protein corresponding to full-length rat JNK3/ SAPK1b. Quality Assurance Routinely evaluated by immunoblot. Stability 2 years at -20°C from date of shipment GenBank A...
Biology Products: