Navigation Links
Disease progression model of pancreatic cancer developed by Penn researchers

Building on previous work, researchers at the University of Pennsylvania School of Medicine have developed an animal model of pancreatic cancer that closely mimics disease progression in humans. From this, they hope to develop new treatments for this deadly disease. Advanced pancreatic cancer is among the most lethal of cancers, with a one-year survival rate after chemotherapy of only 17 to 28 percent of patients, according to the National Cancer Institute.

Sunil R. Hingorani, MD, PhD, and David A. Tuveson, MD, PhD, both in the Departments of Medicine and Cancer Biology, and colleagues, engineered mice to express two mutant genes commonly associated with pancreatic cancer: Kras, an oncogene, and p53, a well-studied tumor suppressor. The investigators linked physiological, cellular, and genomic changes due to mutations in Kras and p53 in the mice to changes similar to that observed in pancreatic cancer patients. They report their findings in the May issue of Cancer Cell.

The disease that develops in the Kras and p53 mutant mouse model demonstrates distinct similarities to human pancreatic cancer at multiple levels. "In terms of clinical presentation, metastatic burden, and histological changes in tissue, this model appears to closely mimic the human disease," says Hingorani.

Clinical symptoms in the mutant mice mirrored those displayed in pancreatic cancer patients, such as abdominal swelling and muscle loss. Similarly, the progression of pancreatic cancer metastases paralleled that seen in the human disease. "In this model, pancreatic cancer metastasizes to the liver, lungs, diaphragm, and adrenal glands, all the same places that human pancreatic cancer metastasizes," says Tuveson.

The frequency of metastases to these various organ sites was also highly similar to that seen in humans. In human patients, 60 to 80 percent develop metastases to the liver; and 50 to 60 percent develop metastases to the lungs. In the genetically modified an
'"/>

Source:University of Pennsylvania


Page: 1 2 3

Related biology news :

1. Transplantation Of Monkey Embryonic Stem Cells Reverses Parkinson Disease In Primates
2. Finding Cures For Tropical Diseases: Is Open Source An Answer?
3. Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease
4. Study: Soap And Water Work Best In Ridding Hands Of Disease Viruses
5. Gene Therapy For Parkinsons Disease Moves Forward In Animals
6. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
7. Discovery Promises Simpler Therapy for Sickle Cell Disease
8. WHO Warns Of Increased Risk Of Vector-borne Diseases In Tsunami-affected Areas
9. Gene Therapy Cures Inherited Liver Disease In Rats
10. Disease diagnosis, biodefense among UH chemical research projects
11. Infants With Rare Genetic Disease Saved by Cord Blood Stem Cells
Post Your Comments:
(Date:1/22/2015)...   EyeLock, Inc. , a market leader of iris-based identity ... to the new role of Senior Vice President of ... of mobile platforms and wearable solutions for EyeLock,s technologies. Gerber ... the semiconductor industry to his role at EyeLock, with expertise ...
(Date:12/22/2014)...  NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) ("NXT-ID" ... growing mobile commerce market, announces it has retained famous pickpocket, ... 2015 International CES debut of the Wocket™ biometric smart wallet.  ... the NXT-ID booth January 6th and 7 th , 2015, ...
(Date:12/19/2014)... , Dec. 18, 2014 Research and Markets ... "iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & ... http://photos.prnewswire.com/prnh/20130307/600769 ... introduced the fingerprint reading feature with the iPhone 5S. ...
Breaking Biology News(10 mins):EyeLock Names Steve Gerber as Senior Vice President of Mobile and Wearables 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2
... in Use, Including Large Scale, Election Enrollment, Retail, Financial, ... ... Demonstrated, WALL, N.J., Sept. 10 BIO-key International,Inc. (OTC ... safety, announced today that the company,is showcasing a variety of deployed ...
... have fully recovered from whaling, were once three to five ... report to be published September 10 in the Proceedings of ... more than 22,000 gray whales has successfully been brought back ... abundant whale on the North American west coast. But the ...
... plans to help health-conscious people better gauge what,s on ... Carol Boushey, an associate professor in the Department of ... a technique already in use by adding a strong ... that monitor eating habits by critiquing photos they send ...
Cached Biology News:BIO-key(R) International to Showcase Deployed Biometric Security Applications at 2007 Biometric Technology Expo 2BIO-key(R) International to Showcase Deployed Biometric Security Applications at 2007 Biometric Technology Expo 3Gray whales a fraction of historic levels, genetic research says 2Purdue researchers click nutrition with camera diet study 2
(Date:12/24/2014)... MA (PRWEB) December 23, 2014 ... is designed to introduce cutting edge communication technology, ... of platform upgrades. This webinar series demonstrates online ... quest to leverage web conferencing’s most innovative and ...
(Date:12/24/2014)... 2014 According to Ross Selinger, President of ... ITRA Global, the national office market continues to be strong, ... is evidenced by the third quarter’s surprising 3.9% GDP, unemployment ... energy costs have held inflation down and the Fed is ...
(Date:12/24/2014)... Nashville Fertility Center announced that Dr. George ... for Reproductive Medicine (ASRM), a leading professional organization committed to ... new role as treasurer, Dr. Hill also fills a seat ... furthering the mission of ASRM. , Dr. Hill has ...
(Date:12/24/2014)... 23, 2014 Pipette.com announces their Holiday ... submit their #HolidayInTheLab pictures for a chance to win pipette-themed ... struggling to think of a holiday gift for their beloved ... the ideal holiday presents. The #HolidayInTheLab Contest encourages Pipette.com ...
Breaking Biology Technology:SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2
... - Oncolytics Biotech Inc. ("Oncolytics") (TSX:ONC, NASDAQ: ONCY ... contract manufacturer, SAFC Pharma(R), a Division of Sigma-Aldrich Corporation, ... of REOLYSIN under cGMP conditions. This run is anticipated ... completed over the next several years as Oncolytics provides ...
... , , , , ... of the i-port(R) and a leader of injection port ... with Unomedical, a leading manufacturer of single use medical devices used ... http://www.newscom.com/cgi-bin/prnh/20090727/DA51373 ) , , The two companies ...
... RIVERSIDE, Calif. Graphene is nature,s thinnest elastic ... Its one-atom thickness, planar geometry, high current-carrying capacity ... further miniaturizing electronics through ultra-small devices and components ... of graphene,s intrinsic features is ripples, similar to ...
Cached Biology Technology:Oncolytics Biotech Inc. Successfully Completes 100-Litre cGMP Production of REOLYSIN(R) 2Patton Medical Devices Partners With Unomedical to Develop and Market the i-port Advance(TM) Injection Port for People Taking Multiple Daily Injections 2Patton Medical Devices Partners With Unomedical to Develop and Market the i-port Advance(TM) Injection Port for People Taking Multiple Daily Injections 3UCR scientists manipulate ripples in graphene, enabling strain-based graphene electronics 2UCR scientists manipulate ripples in graphene, enabling strain-based graphene electronics 3
Human Glypican 2 Biotinylated Affinity Purified PAb...
B2-Microgloulin...
... CTI Molecular Imaging's proprietary Focus™ detector technology, ... as the R4. The microPET Focus ... commerically avaiable PET scanner. Focus scanners ... any scinitallor based PETsystems. The combination ...
...
Biology Products: