Navigation Links
Disease progression model of pancreatic cancer developed by Penn researchers

Building on previous work, researchers at the University of Pennsylvania School of Medicine have developed an animal model of pancreatic cancer that closely mimics disease progression in humans. From this, they hope to develop new treatments for this deadly disease. Advanced pancreatic cancer is among the most lethal of cancers, with a one-year survival rate after chemotherapy of only 17 to 28 percent of patients, according to the National Cancer Institute.

Sunil R. Hingorani, MD, PhD, and David A. Tuveson, MD, PhD, both in the Departments of Medicine and Cancer Biology, and colleagues, engineered mice to express two mutant genes commonly associated with pancreatic cancer: Kras, an oncogene, and p53, a well-studied tumor suppressor. The investigators linked physiological, cellular, and genomic changes due to mutations in Kras and p53 in the mice to changes similar to that observed in pancreatic cancer patients. They report their findings in the May issue of Cancer Cell.

The disease that develops in the Kras and p53 mutant mouse model demonstrates distinct similarities to human pancreatic cancer at multiple levels. "In terms of clinical presentation, metastatic burden, and histological changes in tissue, this model appears to closely mimic the human disease," says Hingorani.

Clinical symptoms in the mutant mice mirrored those displayed in pancreatic cancer patients, such as abdominal swelling and muscle loss. Similarly, the progression of pancreatic cancer metastases paralleled that seen in the human disease. "In this model, pancreatic cancer metastasizes to the liver, lungs, diaphragm, and adrenal glands, all the same places that human pancreatic cancer metastasizes," says Tuveson.

The frequency of metastases to these various organ sites was also highly similar to that seen in humans. In human patients, 60 to 80 percent develop metastases to the liver; and 50 to 60 percent develop metastases to the lungs. In the genetically modified an
'"/>

Source:University of Pennsylvania


Page: 1 2 3

Related biology news :

1. Transplantation Of Monkey Embryonic Stem Cells Reverses Parkinson Disease In Primates
2. Finding Cures For Tropical Diseases: Is Open Source An Answer?
3. Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease
4. Study: Soap And Water Work Best In Ridding Hands Of Disease Viruses
5. Gene Therapy For Parkinsons Disease Moves Forward In Animals
6. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
7. Discovery Promises Simpler Therapy for Sickle Cell Disease
8. WHO Warns Of Increased Risk Of Vector-borne Diseases In Tsunami-affected Areas
9. Gene Therapy Cures Inherited Liver Disease In Rats
10. Disease diagnosis, biodefense among UH chemical research projects
11. Infants With Rare Genetic Disease Saved by Cord Blood Stem Cells
Post Your Comments:
(Date:6/23/2015)... , June 22, 2015 ... the addition of the "Body-Worn Temperature Sensors ... Trends and Forecast 2014 - 2020" report ... strategic analysis of the global body-worn temperature sensors ... been segmented on the basis of types, care ...
(Date:6/18/2015)... , June 18, 2015 NXT-ID, Inc. (NASDAQ: ... focused on the growing mobile commerce market announces that its ... segment on "Money on the Mark", scheduled to air on ... June 20 th . The broadcast ... from 7:00 to 8:00pm EST. NXT-ID, Inc.,s CEO Gino ...
(Date:6/17/2015)... , June 17, 2015  Crossmatch™, a ... announced that its U.are.U ® 4500 fingerprint ... Eateries, Inc., a San ... chain, to increase security, improve accountability and reduce ... enable instant, non-repudiable identity confirmation for employee sign ...
Breaking Biology News(10 mins):Body-Worn Temperature Sensors Market - Global Industry Analysis 2NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 2NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 3Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 2Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 3
... have solved the structure of a crucial human immune ... three. In an upcoming issue of the journal Science, ... composed of 23 leucine-rich repeats (LRRs). , The structure ... before, an essential step toward fully understanding the critical ...
... Pagani in the Department of Geology and Geophysics at ... of atmospheric carbon dioxide between 45 - 25 million ... a National Science Foundation study reported in Science Express. ... makes a contribution to increasing greenhouse gasses, such as ...
... Pagani in the Department of Geology and Geophysics at ... of atmospheric carbon dioxide between 45 - 25 million ... a National Science Foundation study reported in Science Express. ... makes a contribution to increasing greenhouse gasses, such as ...
Cached Biology News:Scripps research scientists solve structure of a critical innate immune system protein 2Scripps research scientists solve structure of a critical innate immune system protein 3Scripps research scientists solve structure of a critical innate immune system protein 4Stem cells grown in lab mirror normal developmental steps 2Invasive parasite destroying fish species 2
(Date:7/1/2015)... India , July 1, 2015  Strand Life ... generation sequencing technology to empower cancer care, today announced ... chief executive officer. In his expanded role as now ... strategy, business expansion and worldwide operations effective immediately.  Dr. ... chairman and CEO since its founding in 2000, will ...
(Date:7/1/2015)... CHANDLER, Ariz. , July 1, 2015 ... announced it has earned three Gold, three Silver, and ... Business Awards gala held in Chicago ... recognized as the premier business awards program in the ... and recognizes our company,s strength in developing leaders, cultivating ...
(Date:7/1/2015)... ... 2015 , ... Apex Therapeutics announced today that company CEO, David Broecker provided ... , The presentation took place on Tuesday, June 16 and provided an update on ... for the treatment of pancreatic cancer. A copy of the company overview can ...
(Date:6/30/2015)... -- R-Japan Co.,Ltd. obtained the license of cell processing facility ... the Ministry of Health, Labour and Welfare Kinki Bureau of ... The fact that R- Japan received the ... and Medical Devices Agency (PMDA) on May 18, 2015 two ... cell manufacturing service to medical institutions. As of November 25, ...
Breaking Biology Technology:Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 2Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 3Isagenix Earns Nine American Business Awards 2Isagenix Earns Nine American Business Awards 3Apex Therapeutics Presented Company Overview at This Year’s BIO International Convention in Philadelphia, PA 2R-Japan Obtained Autologous Stem Cell Manufacturing License from the Ministry of Health, Labour and Welfare 2
... - Merge eFilm , a global health ... release of eFilm Workstation 1.9 and InSight ... for 10 imaging centers. , ,eFilm Workstation is ... ability to view and manipulate digital diagnostic studies. ...
... the anger engendered by their rush to offshore outsource. ... workers have been relentlessly and brutally downsized and reengineered ... been the worst. Many people who lost their jobs ... positions. Not surprisingly, they are bitter and scared. Many ...
... Wisconsin Investments Board has chosen Eagle Investment ... Wisconsin retirement system trust funds. SWIB controls the ninth ... Eagles solutions to help facilitate its internal initiatives for ... because they will help us establish a readily accessible ...
Cached Biology Technology:The "Big Squeeze" - Look for a job or be an entrepreneur? 2The "Big Squeeze" - Look for a job or be an entrepreneur? 3
... were designed for full-length gene cloning and ... identify the desired cDNA clone. The first ... "Master Plate," where each well contains plasmid ... positive well(s) by gel electrophoresis of the ...
... research grade spectrofluorometer which offers high sensitivity, ... up to 60,000nm/min. Its horizontal beam ... beam along with low sample volume requirements. ... PC fluorescence applications software, which offers Excitation/Emission ...
... Pathway Studio Enterprise is integrated ... cellular regulatory mechanisms and drug response ... ResNet, the worlds largest knowledge base ... equipped with MedScan module capable of ...
... cDNA Library Panels were designed for full-length ... of PCRs to identify the desired cDNA ... in a 96-well "Master Plate," where each ... Having identified the positive well(s) by gel ...
Biology Products: