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Discovery suggests why stem cells run through stop signs

cell division of the mutant stem cells, just like ordinary cells. The cellular brake (in this case a protein called Dacapo, a fruit fly homologue of a human tumor suppressor) kept the stem cells from proliferating.

"Determining which of the 80 microRNAs is responsible for deactivating the stop signal is the next step of our research," said Ruohola-Baker.

"The list of chores that microRNAs do within cells keeps growing in new and surprising ways," added Carthew. "This latest discovery with stem cell division makes us wonder if microRNAs also control division of other types of cells such as cancer cells."

Other authors on the Nature paper are Kenji Nakahara of Northwestern University and Karin Fischer, Steve Hatfield and Halyna Shcherbata of the University of Washington.


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Source:Northwestern University


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