Navigation Links
Discovery suggests why stem cells run through stop signs

Everyone knows that stem cells are controversial. Many people know that stem cells can grow into virtually any cell type found in the body, from a red blood cell to a muscle cell to a brain cell. But no one really knows why stem cells continue to divide and renew themselves long after the point where other cells stop dividing.

Now scientists at Northwestern University and the University of Washington offer one of the first clues as to why stem cells ignore stop signs in the cell cycle: a special molecular mechanism has cut the brakes. The researchers found that tiny bits of genetic material called microRNAs are necessary for stem cell division to take place, suggesting that microRNAs shut off the signals that stop cell division in most other cells.

The findings were published online this week by the journal Nature. In the paper, the researchers also speculate that microRNAs may play a similar role in cancer cells, encouraging their proliferation. This speculation is supported by three other new papers published this week in Nature linking microRNAs to cancer.

According to authors Richard Carthew, Owen L. Coon Professor of Molecular Biology at Northwestern University, and Hannele Ruohola-Baker, professor of biochemistry at the University of Washington, microRNAs can regulate gene expression and give stem cells a green light to pass from the normal stop phase to the stage in which they begin replicating their DNA for later division.

In their work, Carthew and Ruohola-Baker focused on fruit flies, which have approximately 80 types of microRNAs. They genetically modified stem cells from the fruit flies' ovaries and studied how many egg chambers the mutant stem cells produced as compared to normal stem cells. The production rate in the mutant cells fell over the course of 12 days, and the researchers concluded it was because the mutant stem cells were no longer dividing.

Without the microRNAs at work, the brakes were applied to the
'"/>

Source:Northwestern University


Page: 1 2

Related biology news :

1. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
2. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
3. UCSD Discovery Shows How Embryonic Stem Cells Perform Quality Control Inspections
4. Discovery Could Lead To Novel Approaches In HIV Treatment
5. Discovery Promises Simpler Therapy for Sickle Cell Disease
6. Discovery may lead to better Candidiasis drug
7. Protein Discovery Could Unlock The Secret To Better TB Treatment
8. Discovery clarifies role of peptide in biological clock
9. Eliminate Data Analysis Bottlenecks in Drug Discovery
10. Discovery of New Dopamine Action May Yield Alternative Psychiatric Drugs
11. Discovery could be key to bioterrorism defense
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Discovery suggests why stem cells run through stop signs

(Date:2/24/2015)... , Feb. 24, 2015 This report analyzes the worldwide ... following Segments: Face Biometrics, and Voice Biometrics. The report provides separate ... Japan , Europe , ... Africa , and Latin America . ... 2020. Also, a seven-year historic analysis is provided for these markets. ...
(Date:2/23/2015)... Feb. 23, 2015 NXT-ID, Inc. (NASDAQ: ... a biometric authentication company focused on the growing mobile ... patent 62114357 for DISTRIBUTED VOICE DIRECTED PAYMENT ... introduces a new groundbreaking payment method. Payment accounts may ... may only be accessed if both the speech (the ...
(Date:2/18/2015)... , Feb. 18, 2015  Cepheid (NASDAQ: CPHD ... the following conferences, and invited investors to participate via webcast. ... Boston, MA Tuesday, March 3, 2015 at 11.20 ... Orlando, FL Wednesday, March 4, 2015 ... To access the live webcasts for these events, please visit ...
Breaking Biology News(10 mins):World Face and Voice Biometrics Industry 2World Face and Voice Biometrics Industry 3World Face and Voice Biometrics Industry 4World Face and Voice Biometrics Industry 5World Face and Voice Biometrics Industry 6World Face and Voice Biometrics Industry 7World Face and Voice Biometrics Industry 8World Face and Voice Biometrics Industry 9World Face and Voice Biometrics Industry 10World Face and Voice Biometrics Industry 11World Face and Voice Biometrics Industry 12World Face and Voice Biometrics Industry 13World Face and Voice Biometrics Industry 14World Face and Voice Biometrics Industry 15World Face and Voice Biometrics Industry 16NXT-ID Patents Voice Directed Payments 2NXT-ID Patents Voice Directed Payments 3Cepheid to Webcast Upcoming Financial Presentations 2
... "call for help" by emitting volatiles, which can indirectly ... infect, consume and kill the herbivores, to the benefit ... also be detected by other organisms. A new study ... PLOS Biology shows how secondary parasitoids (,hyperparasitoids,) can ...
... show in mice how nerves may be damaged during ... suggest that the critical step happens when fibrinogen, a ... activates immune cells called microglia. "We have shown ... an associate investigator at the Gladstone Institute for Neurological ...
... French . , Clinician-scientists take a unique, ... Problems encountered in the clinic inspire research and new findings ... integrated model is a hallmark of the Montreal Neurological Institute ... MUHC and is now being replicated worldwide. Two clinician-scientists at ...
Cached Biology News:The hungry caterpillar: Beware your enemy's enemy's enemy 2NIH-funded researchers show possible trigger for MS nerve damage 2Clinician-scientists at The Neuro receive funding for Parkinson's and HIV research 2
(Date:3/3/2015)... , March 3, 2015  Thingee Corporation, a ... be delivering a presentation entitled, "Technology Adoption: Making Reps, ... Thriving through Innovations and Technology ,  in ... 11 to 13, 2015. Audiences looking to learn how ... will want to be in the audience for the ...
(Date:3/3/2015)... 3, 2015 AtheroNova Inc. (OTCQB: AHRO) today announced ... voluntary petitions under Chapter 11 of the U.S. Bankruptcy Code ... California , Santa Ana division ... 11 cases are expected to be jointly administered. ... supervised asset sale process, for all or substantially all of ...
(Date:3/3/2015)... 2015 Becht Engineering Co., Inc., ... has acquired The CECON Group, Inc., located in ... not announced. , Becht Engineering (http://www.becht.com ) ... including oil and gas production, refining, petrochemical, chemical, ... power sectors. The company has twelve offices in ...
(Date:3/3/2015)... Cambridge Semantics, the leading provider of smart data ... it has been named to KMWorld’s 2015 list of ... , To create the list each year, KMWorld assembles ... who identify organizations dedicated to the true value of ... right people at the right time. , “The ...
Breaking Biology Technology:Thingee to present at 11th Annual Synergistix Users Conference 2AtheroNova and its Subsidiary File for Chapter 11 Bankruptcy Protection 2AtheroNova and its Subsidiary File for Chapter 11 Bankruptcy Protection 3AtheroNova and its Subsidiary File for Chapter 11 Bankruptcy Protection 4Cambridge Semantics Named to KMWorld’s 2015 ‘100 Companies That Matter in Knowledge Management’ 2
... available in German . , They have been ... and now they are making rapid inroads in high performance ... cell phones and digital cameras. The automotive industry, for instance, ... increasingly using them in driver assistance systems from parking ...
... Scarguard Labs, LLC, a closely held company specializing in ... through the use of multi-technology drugs enhanced by a ... received approval from Health Canada to sell Scarguard to ... very pleased to gain approval for retail in our ...
... NEW YORK, Feb. 23, 2011 Stemline Therapeutics, Inc., ... that target cancer stem cells (CSCs), today announced that ... ("Pitt"), for the exclusive worldwide rights to a clinically ... tumor bulk and CSCs. Developed by Dr. Hideho Okada, ...
Cached Biology Technology:UV-transparent coating for image sensors 2Stemline Therapeutics Licenses Phase I/II Brain Cancer Vaccine - Shows Promise in Clinical Trial Conducted at University of Pittsburgh 2Stemline Therapeutics Licenses Phase I/II Brain Cancer Vaccine - Shows Promise in Clinical Trial Conducted at University of Pittsburgh 3
Goat polyclonal to CHMP5 ( Abpromise for all tested applications). Antigen: Synthetic peptide: C-NKDGVLVDEFGLPQ, corresponding to C terminal amino acids 202-215 of Human CHMP5 Entrez GeneID: ...
... Rabbit polyclonal to MKK6 (phospho S207) ... applications). Antigen: ... around the phosphorylation site of Serine ... Entrez Gene ID: 5608 ...
Rabbit polyclonal to Reptin/TIP49B/RUVB2 ( Abpromise for all tested applications). Antigen: Synthetic peptide (Human) Entrez Gene ID: 10856 Swiss Protein ID: Q6FIB9...
Mouse monoclonal [1Q17] to TGE Virus peplomer ( Abpromise for all tested applications)....
Biology Products: