Navigation Links
Discovery suggests why stem cells run through stop signs

Everyone knows that stem cells are controversial. Many people know that stem cells can grow into virtually any cell type found in the body, from a red blood cell to a muscle cell to a brain cell. But no one really knows why stem cells continue to divide and renew themselves long after the point where other cells stop dividing.

Now scientists at Northwestern University and the University of Washington offer one of the first clues as to why stem cells ignore stop signs in the cell cycle: a special molecular mechanism has cut the brakes. The researchers found that tiny bits of genetic material called microRNAs are necessary for stem cell division to take place, suggesting that microRNAs shut off the signals that stop cell division in most other cells.

The findings were published online this week by the journal Nature. In the paper, the researchers also speculate that microRNAs may play a similar role in cancer cells, encouraging their proliferation. This speculation is supported by three other new papers published this week in Nature linking microRNAs to cancer.

According to authors Richard Carthew, Owen L. Coon Professor of Molecular Biology at Northwestern University, and Hannele Ruohola-Baker, professor of biochemistry at the University of Washington, microRNAs can regulate gene expression and give stem cells a green light to pass from the normal stop phase to the stage in which they begin replicating their DNA for later division.

In their work, Carthew and Ruohola-Baker focused on fruit flies, which have approximately 80 types of microRNAs. They genetically modified stem cells from the fruit flies' ovaries and studied how many egg chambers the mutant stem cells produced as compared to normal stem cells. The production rate in the mutant cells fell over the course of 12 days, and the researchers concluded it was because the mutant stem cells were no longer dividing.

Without the microRNAs at work, the brakes were applied to the
'"/>

Source:Northwestern University


Page: 1 2

Related biology news :

1. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
2. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
3. UCSD Discovery Shows How Embryonic Stem Cells Perform Quality Control Inspections
4. Discovery Could Lead To Novel Approaches In HIV Treatment
5. Discovery Promises Simpler Therapy for Sickle Cell Disease
6. Discovery may lead to better Candidiasis drug
7. Protein Discovery Could Unlock The Secret To Better TB Treatment
8. Discovery clarifies role of peptide in biological clock
9. Eliminate Data Analysis Bottlenecks in Drug Discovery
10. Discovery of New Dopamine Action May Yield Alternative Psychiatric Drugs
11. Discovery could be key to bioterrorism defense
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Discovery suggests why stem cells run through stop signs

(Date:7/22/2014)... Institute of Standards and Technology (NIST), working with ... technique for analyzing biological cells and tissues based ... technique is an advanced form of the widely ... signals that are 10,000 times stronger than obtained ... than obtained from comparable "coherent Raman" instruments, and ...
(Date:7/22/2014)... commercial diet programs and pills, the Weight Watchers program ... the money. The Jenny Craig regimen generated the greatest ... tested, according to researchers at Duke-National University of Singapore ... the June issue of the journal Obesity , ... per dollar spent as insurance carriers consider coverage for ...
(Date:7/22/2014)... Nancy Buccola, MSN, APRN, PMHCNS-BC, CNE, Assistant Professor ... New Orleans School of Nursing, contributed samples used ... material associated with schizophrenia and also suggesting a ... The study, Biological insights from 108 schizophrenia-associated genetic ... Nature , available at http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13595.html., ...
Breaking Biology News(10 mins):Enhanced NIST instrument enables high-speed chemical imaging of tissues 2Enhanced NIST instrument enables high-speed chemical imaging of tissues 3Study compares cost-effectiveness of weight-loss programs and drugs 2Study compares cost-effectiveness of weight-loss programs and drugs 3LSUHSC contributes to work identifying new DNA regions associated with schizophrenia 2
... of an embryonic stem cell, which has the potential to ... complex interaction of genes, proteins that bind DNA, and molecules ... paper, biologists from MIT and the University of California at ... of stem cells into mature heart cells. The study, the ...
... ultrasound waves, MIT engineers have found a way to ... drug delivery more efficient. This technology could pave the ... to the researchers. "This could be used for ... systemic drugs and proteins such as insulin, as ...
... Alps that are not native to that region? Which ... How big a threat will they become to local ... today by the European Commission,s in-house science service, the ... answering these and other questions related to 16 000 ...
Cached Biology News:Probing matters of the heart 2Probing matters of the heart 3Getting (drugs) under your skin 2Getting (drugs) under your skin 3Environment: Pooling information to combat the threat of alien species in Europe 2Environment: Pooling information to combat the threat of alien species in Europe 3
(Date:7/22/2014)... 22, 2014 Quorum Review IRB, the industry ... large clinical trials called Quick Step™ . The offering ... address the research industry’s need for seamless study start-up with ... available for studies planning 50 or more North American investigator ... North American site count of 80 or more. Qualifying studies ...
(Date:7/22/2014)... New Jersey , 22. Juli 2014 /PRNewswire/ ... die Life-Sciences-Industrie, hat die Ernennung von Marcus Bergler ... bekanntgegeben. Herr Bergler hat die europäischen kommerziellen Aktivitäten ... unterstützt. Bevor er sich Qforma anschloss, war er ... Cegedim Customer Information, als Vertriebsteam-Leiter Deutschland bei IMS ...
(Date:7/22/2014)... 2014 Dr. Williams says, “Bush has ... recognized that the greatest health care system in the ... needlessly deadly while trying to serve the public. Unfortunately, ... to transform an enormous system that none of them ... his continuing series of Open Letters ( http://is.gd/wdU2CM ) ...
(Date:7/21/2014)... a chain of carbon atoms can turn it from ... University scientists. , Stretching the material known as carbyne ... by just 3 percent can begin to change its ... mechanically activated nanoscale electronics and optics. , The finding ... appears in the American Chemical Society journal Nano ...
Breaking Biology Technology:Quorum Review IRB Launches New Quick Step™ Service for Large Clinical Trials 2Quorum Review IRB Launches New Quick Step™ Service for Large Clinical Trials 3Qforma gibt Schaffung des neuen Postens als General Manager in Europa bekannt 2Dr. Ira Williams Asks What’s Wrong With Jonathan Bush’s Book, Where Does It Hurt? 2Carbyne morphs when stretched 2Carbyne morphs when stretched 3
... MOUNTAIN VIEW, Calif., Feb. 25 Alexza,Pharmaceuticals, ... that it has initiated,its first Phase 3 ... an inhalation product candidate being developed for ... schizophrenia or bipolar disorder. Alexza,believes the novel, ...
... t2cure, a clinical,stage biopharmaceutical company developing novel regenerative ... it has appointed,Dr. Petra Rueck Head of Clinical ... join our company", said Manfred Ruediger,CEO of t2cure. ... be of critical importance to t2cure as we ...
... SAN DIEGO, Feb. 25 Speid & Associates, ... is hosting,a six session Webinar series on diabetes ... and April. Speakers will include former Food and,Drug ... Lipicky, as,well as a distinguished list of other ...
Cached Biology Technology:Alexza Initiates First Phase 3 Clinical Trial for AZ-004 (Staccato(R) Loxapine) 2Alexza Initiates First Phase 3 Clinical Trial for AZ-004 (Staccato(R) Loxapine) 3Alexza Initiates First Phase 3 Clinical Trial for AZ-004 (Staccato(R) Loxapine) 4Alexza Initiates First Phase 3 Clinical Trial for AZ-004 (Staccato(R) Loxapine) 5Stem Cell Company t2cure Appoints Dr Rueck Head of Clinical Operations 2The Diabetes Series 2008: Experts Speak About Developing Diabetes Therapeutics 2
... of the routine trace metal analytical lab ... and simple to use instrumentation. The 7500ce ... challenging sample matrices found in the environmental ... toughest analytical challenges found in the clinical, ...
C1-inhibitor (C1-INH)...
Polio component type I...
Procollagen type I C-terminal propeptide (human, PICP)...
Biology Products: