( to humancells?said Beth Mann a rese...)Discovery of key protein's shape could lead to improved bacterial pneumonia vaccine

to human cells,?said Beth Mann, a research laboratory specialist in Tuomanen’s lab who developed the bacteria carrying mutated CbpA. Mann, co-author of the paper, also showed that the long, paddle-shaped extensions of the protein must be folded in a specific way in order for CbpA to work. The discovery of the actual shape of CbpA was made using nuclear magnetic resonance (NMR) spectroscopy and circular dishroism (CD). NMR combines radio wave emissions and a powerful magnetic field to determine the structure of proteins suspended in solutions, while CD measures differences in the absorption of different types of polarized light by molecules to determine their shape. It also can show how that shape can change when the protein interacts with another molecule. “This work required that we develop new NMR methods in order to determine the shape of this protein, which undergoes changes as it interacts with pIgR,?said Rensheng Luo, Ph.D., a post-doctoral fellow in St. Jude Structural Biology and Infectious Diseases and first author of the paper.
'"/>

Source:St. Jude Children's Research Hospital


Page: 1 2 3
Related biology news :

1. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
2. UCSD Discovery Shows How Embryonic Stem Cells Perform Quality Control Inspections
3. Discovery Could Lead To Novel Approaches In HIV Treatment
4. Discovery Promises Simpler Therapy for Sickle Cell Disease
5. Discovery may lead to better Candidiasis drug
6. Protein Discovery Could Unlock The Secret To Better TB Treatment
7. Discovery clarifies role of peptide in biological clock
8. Eliminate Data Analysis Bottlenecks in Drug Discovery
9. Discovery of New Dopamine Action May Yield Alternative Psychiatric Drugs
10. Discovery could be key to bioterrorism defense
11. Discovery of an American salamander where it shouldnt be: Korea