Navigation Links
Discovery of key protein's shape could lead to improved bacterial pneumonia vaccine

Scientists at St. Jude Children's Research Hospital have discovered that the shape of a protein on the surface of pneumonia bacteria helps these germs invade the human bloodstream. This finding, published Dec. 16 online by the EMBO Journal, could help scientists develop a vaccine that is significantly more effective at protecting children against the disease. The St. Jude researchers determined the shape of a large, paddle-like molecule that Streptococcus pneumoniae bacteria use to latch onto cells lining the throat and lungs. The protein, called CbpA, binds to a molecule on the cell called pIgR, which takes antibodies from the bloodstream on one side of the cell and transports them to the other side. There it releases the antibody at the lining of the throat and lungs. If a pneumococcus bacterium is hovering on the lining of the respiratory tract, this germ binds to pIgR and pushes this antibody shuttle back through the cell to the bloodstream. Once at the other side of the cell, the pneumococcus breaks free of pIgR and enters the blood, where it can multiply and infect the body.

S. pneumoniae is the only bacterium known to use CbpA to invade human cells by binding to pIgR, according to Richard W. Kriwacki, Ph.D., associate member of St. Jude Structural Biology. Kriwacki is senior author of the EMBO Journal report. “The fact that we now know the structure of this important protein means we can begin to develop a vaccine that is more effective in children than those that are currently available,?Kriwacki said. Elaine Tuomanen, M.D., chair of Infectious Diseases and director of the Children’s Infection Defense Center at St. Jude, is co-author of the EMBO Journal paper. “Using CbpA as the key part of a new vaccine against S. pneumoniae would solve a problem that now hinders our ability to protect children from this infection,?Tuomanen said. Current pneumonia vaccines designed to protect adults against more than two dozen strains of S. pneumoniae do not work in
'"/>

Source:St. Jude Children's Research Hospital


Page: 1 2 3

Related biology news :

1. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
2. UCSD Discovery Shows How Embryonic Stem Cells Perform Quality Control Inspections
3. Discovery Could Lead To Novel Approaches In HIV Treatment
4. Discovery Promises Simpler Therapy for Sickle Cell Disease
5. Discovery may lead to better Candidiasis drug
6. Protein Discovery Could Unlock The Secret To Better TB Treatment
7. Discovery clarifies role of peptide in biological clock
8. Eliminate Data Analysis Bottlenecks in Drug Discovery
9. Discovery of New Dopamine Action May Yield Alternative Psychiatric Drugs
10. Discovery could be key to bioterrorism defense
11. Discovery of an American salamander where it shouldnt be: Korea
Post Your Comments:
(Date:8/29/2014)... species of marine phytoplankton, such as the prolific bloomer ... B1 (thiamine), researchers have discovered. The finding contradicts the ... other eukaryotic microbes depend on scarce supplies of thiamine ... different way to think about the ocean," says CIFAR ... The ISME Journal paper with CIFAR fellows ...
(Date:8/28/2014)... Society of America (ESA) is pleased to announce the ... of the Society. Honorary Membership acknowledges those who have ... involvement in the affairs of the Society that has ... selected by the ESA Governing Board and then voted ... honored at the Awards Ceremony at Entomology 2014, ESA,s ...
(Date:8/28/2014)... MD FASEB MARC (Maximizing Access to Research Careers) ... American Society of Human Genetics from October 18 ... are meant to promote the entry of students, post ... of the basic science community and to encourage the ... Human Genetics. This year MARC conferred 16 awards ...
Breaking Biology News(10 mins):Not all phytoplankton in the ocean need to take their vitamins 2Not all phytoplankton in the ocean need to take their vitamins 3Fred Baxendale selected as Honorary Member of the Entomological Society of America 2
... A tissue-repair-and-regeneration pathway in the human body, including ... develop properly. Genetically engineered mice fail to develop ... Wnt2b, are knocked out. The findings are described this ... to know the answer to a seemingly simple question: ...
... NOAA Fisheries scallop survey off the northeastern U.S. coast ... "recruit" sea scallops and ocean quahogs on Georges Bank ... Mid-Atlantic for 2009. This survey, which included the first ... underwater imaging system from the same vessel, also shows ...
... have discovered the first protein-based toxin in an amphibian a ... Chinese tree frog. This finding may help shed more light ... poison. While gene-encoded protein toxins have been identified ... have yet been found in amphibians or birds. In the ...
Cached Biology News:How to make a lung 2Annual survey shows high numbers of seed scallops on Georges Bank, low numbers in Mid-Atlantic 2Annual survey shows high numbers of seed scallops on Georges Bank, low numbers in Mid-Atlantic 3Annual survey shows high numbers of seed scallops on Georges Bank, low numbers in Mid-Atlantic 4
(Date:8/29/2014)... California (PRWEB) August 29, 2014 ... of Energy's 2014 Hydrogen Production R&D Award ... -- by splitting water using sunlight. , Shared ... (NREL) and the University of Nevada, Las Vegas ... work developing models of photoelectrochemical solar-hydrogen production and ...
(Date:8/28/2014)... August 28, 2014 SPIE Fellow Glenn ... and Optical Science and Director of the Center for ... Carolina at Charlotte, and co-founder and Chairman of the ... as the 2015 Vice President of SPIE, the international ... Philip Stahl announced recent election results at the Annual ...
(Date:8/28/2014)... A new research platform uses a ... tiny structures undergoing stress and heating, an ... designs for microelectronics and batteries., This new ... about how heating and the surface stress ... Researchers have discussed the merits of surface-stress ...
(Date:8/28/2014)... , Aug. 28, 2014  Next month, executives from clinical ... key industry events beginning with Patient-Centered Clinical Trials 2014 ... Boston , September 4-5. Patient recruitment experts ... Aaron Fleishman will share insights on the benefits ... variety of tactics – from media to mobile apps – ...
Breaking Biology Technology:Livermore Team Awarded for Hydrogen Production Research 2Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2New analytical technology reveals 'nanomechanical' surface traits 2New analytical technology reveals 'nanomechanical' surface traits 3BBK Worldwide Leads Sessions at Key September Events 2
... $59.0 Million, Up 46 Percent Over Third Quarter ... 2006, - Third Quarter EPS of $0.70 per Basic ... $1.19 per Diluted ... Share, SILVER SPRING, Md., Nov. 1 United,Therapeutics Corporation (Nasdaq: UTHR ) today announced ...
... (Nasdaq: NBIX ) today announced that it has ... commercialization of indiplon,in Japan with Dainippon Sumitomo Pharma Co, ... for indiplon in the US for the,treatment of insomnia. ... with a,PUDFA action date of December 12, 2007. ...
... Biopure Corporation,(Nasdaq: BPUR ) announced today the pricing ... to closing conditions, the,underwriters have agreed to purchase from ... warrants to acquire an additional 16,850,000,new shares. The price ... the,exercise price of each warrant is $1.06. This transaction ...
Cached Biology Technology:United Therapeutics Reports Third Quarter 2007 Financial Results 2United Therapeutics Reports Third Quarter 2007 Financial Results 3United Therapeutics Reports Third Quarter 2007 Financial Results 4United Therapeutics Reports Third Quarter 2007 Financial Results 5United Therapeutics Reports Third Quarter 2007 Financial Results 6United Therapeutics Reports Third Quarter 2007 Financial Results 7United Therapeutics Reports Third Quarter 2007 Financial Results 8United Therapeutics Reports Third Quarter 2007 Financial Results 9Neurocrine Biosciences and Dainippon Sumitomo Pharma (DSP) Announce Agreement to Develop and Commercialize Indiplon in Japan 2Neurocrine Biosciences and Dainippon Sumitomo Pharma (DSP) Announce Agreement to Develop and Commercialize Indiplon in Japan 3Biopure Announces Pricing of Equity Offering 2
Anti-gamma Glutamyl Transferase (gammaGT) Host: mouse monoclonal Species Reactivity: human Applications: WB, IP, FC Storage: 4C...
Anti-DDDDK-Tag (Enterokinase Cleavage Site), Agarose Conjugate Research Focus: tag Storage: 4C Shipping Temperature: 4C...
Anti-ACTH Immunogen: Porcine ACTH conjugated to BSA. Available Date: 38566...
Rabbit polyclonal to SERHL ( Abpromise for all tested applications). entrezGeneID: 94009 SwissProtID: Q9H4I8...
Biology Products: