( otein-coupled receptors which when occ...)Discovery of T-cell 'traffic control' boosts new drug promise

otein-coupled receptors, which when occupied by chemokines -- their natural binding partners -- prompt the T cells to rush into lymph nodes. But S1P, they found, can act through its own G-coupled receptors to prevent chemokines from triggering T cell movement. In ways not yet fully understood, this process is reversible, providing the body with a crucial control over when and how much of the potent T cell soldiers to release into the blood stream.

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Source:University of California - San Francisco


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