Navigation Links
Discovery in the evolution of the immune system absorbing cells

Led by Dr J Oriol Sunyer, of the Faculty of Veterinary Medicine at the University of Pennsylvania, and formed by researchers from Philadelphia, St Louis and Idaho (USA) and by Dr Lluís Tort of the Universitat Autònoma de Barcelona, the group has been able to show that B cells in fish as well as in amphibians are capable of strong phagocytosis both in in vivo and in vitro experiments. The work has been published in Nature Immunology, the most prestigious journal worldwide in the field of immunology.

According to Dr Sunyer, "this is important so that we can understand not only how the immune systems of fish and amphibians work but also the origin and composition of the immune systems of humans and mammals". The work concludes that there is an evolutionary relationship between macrophages and cells by which both cell types derive from a common, ancestral cell with functional properties of both cells. So though the B cells of lower vertebrates (fish and amphibians) are still capable of phagocytis while they are producing antibodies, the B cells of higher vertebrates are no longer capable of phagocytis. The latter specialise almost exclusively in functions of the adaptive immune response.

It is most probable that the less-elaborated, restrictive adaptive immune response of fish and amphibians makes the preservation of phagocytosis an evolutionary advantage to B cells in their defence against pathogens. One cannot forget that fish have had a significant evolutionary success, since nearly 50% of vertebrate species belong to this group and they are constantly in contact with a vast multitude of microorganisms in the water. According to Dr Sunyer, "From a practical perspective, this discovery will be used in the near future to produce a new design of vaccines for fish in order to stimulate phagocytosis in antibodies for B cells, increasing the effectiveness of the vaccine".

The study of comparative biology remains an important source of scientific k nowledge. Several years ago, the same researchers demonstrated the great versatility and power of the innate immune response of the complement system in lower vertebrates, whereas mammals have developed greater effectiveness and specialisation in the adaptive mechanism of antibodies.
'"/>

Source:Universitat Autonoma de Barcelona


Related biology news :

1. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
2. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
3. UCSD Discovery Shows How Embryonic Stem Cells Perform Quality Control Inspections
4. Discovery Could Lead To Novel Approaches In HIV Treatment
5. Discovery Promises Simpler Therapy for Sickle Cell Disease
6. Discovery may lead to better Candidiasis drug
7. Protein Discovery Could Unlock The Secret To Better TB Treatment
8. Discovery clarifies role of peptide in biological clock
9. Eliminate Data Analysis Bottlenecks in Drug Discovery
10. Discovery of New Dopamine Action May Yield Alternative Psychiatric Drugs
11. Discovery could be key to bioterrorism defense

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/2/2016)... Feb. 2, 2016   Parabon NanoLabs ... U.S. Army Research Office and the Defense Forensics ... sensitivity of the company,s Snapshot Kinship Inference ... and, more generally, defense-related DNA forensics.  Although Snapshot ... (predicting appearance and ancestry from DNA evidence), it ...
(Date:2/1/2016)... , Feb. 1, 2016  Today, the first day ... announced plans to develop a first of its kind ... of IBM Watson. In the first application of ... (NYSE: IBM ), and Welltok will create a ... assessments with cognitive analytics, delivered on Welltok,s health optimization ...
(Date:1/27/2016)... , Jan. 27, 2016  Rite Track, Inc. ... in West Chester, Ohio announced ... winning service staff, based in Austin, Texas ... and ability to provide modifications, installations and technical support ... , CEO of PLUS, commented, "PLUS has provided world ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... 11, 2016 --> ... "Company") (OTCQB: PSID), a life sciences company focused ... Thermomedics subsidiary, which markets the Caregiver® FDA-cleared non-contact ... in January 2016, including entering into agreements with ... sales growth, and establishing several near-term pipeline opportunities. ...
(Date:2/11/2016)... ... February 11, 2016 , ... ... 150 years, continues today to pursue the highest level of accuracy and quality ... the AR9 Refractometer and the AR5 Refractometer. Accurate, reliable and tough enough ...
(Date:2/11/2016)... (PRWEB) , ... February 11, 2016 , ... ... of its new stem cell treatment clinic in Quito, Ecuador. The new facility ... and trauma applications to patients from around the world. , The new ...
(Date:2/10/2016)... 2016 Early-career researchers from ... , Uganda and Yemen ... and nutrition   Indonesia , Nepal ... and Yemen are being honored for their accomplishments ... also celebrated for mentoring young women scientists who are pursuing careers in ...
Breaking Biology Technology: