Navigation Links
Discovery in the evolution of the immune system absorbing cells

Led by Dr J Oriol Sunyer, of the Faculty of Veterinary Medicine at the University of Pennsylvania, and formed by researchers from Philadelphia, St Louis and Idaho (USA) and by Dr Lluís Tort of the Universitat Autònoma de Barcelona, the group has been able to show that B cells in fish as well as in amphibians are capable of strong phagocytosis both in in vivo and in vitro experiments. The work has been published in Nature Immunology, the most prestigious journal worldwide in the field of immunology.

According to Dr Sunyer, "this is important so that we can understand not only how the immune systems of fish and amphibians work but also the origin and composition of the immune systems of humans and mammals". The work concludes that there is an evolutionary relationship between macrophages and cells by which both cell types derive from a common, ancestral cell with functional properties of both cells. So though the B cells of lower vertebrates (fish and amphibians) are still capable of phagocytis while they are producing antibodies, the B cells of higher vertebrates are no longer capable of phagocytis. The latter specialise almost exclusively in functions of the adaptive immune response.

It is most probable that the less-elaborated, restrictive adaptive immune response of fish and amphibians makes the preservation of phagocytosis an evolutionary advantage to B cells in their defence against pathogens. One cannot forget that fish have had a significant evolutionary success, since nearly 50% of vertebrate species belong to this group and they are constantly in contact with a vast multitude of microorganisms in the water. According to Dr Sunyer, "From a practical perspective, this discovery will be used in the near future to produce a new design of vaccines for fish in order to stimulate phagocytosis in antibodies for B cells, increasing the effectiveness of the vaccine".

The study of comparative biology remains an important source of scientific k nowledge. Several years ago, the same researchers demonstrated the great versatility and power of the innate immune response of the complement system in lower vertebrates, whereas mammals have developed greater effectiveness and specialisation in the adaptive mechanism of antibodies.
'"/>

Source:Universitat Autonoma de Barcelona


Related biology news :

1. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
2. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
3. UCSD Discovery Shows How Embryonic Stem Cells Perform Quality Control Inspections
4. Discovery Could Lead To Novel Approaches In HIV Treatment
5. Discovery Promises Simpler Therapy for Sickle Cell Disease
6. Discovery may lead to better Candidiasis drug
7. Protein Discovery Could Unlock The Secret To Better TB Treatment
8. Discovery clarifies role of peptide in biological clock
9. Eliminate Data Analysis Bottlenecks in Drug Discovery
10. Discovery of New Dopamine Action May Yield Alternative Psychiatric Drugs
11. Discovery could be key to bioterrorism defense

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/2/2017)... Who risk to be deprived of its imprint in ... https://www.reportbuyer.com/product/4313699/ WILL APPLE AND SAMSUNG CONFRONT EACH ... using capacitive technology represent a fast growing market, especially ... increase of 360% of the number of fingerprint sensor ... market between 2014 and 2017 (source : N+1 Singer, ...
(Date:3/1/2017)... , March 1, 2017  Aware, Inc. (NASDAQ: ... announced that Richard P. Moberg has resigned, ... co-President and Chief Financial Officer and Treasurer of Aware ... to serve as a member of the Board of ... , Aware,s co-Chief Executive Officer and co-President, General Counsel ...
(Date:2/28/2017)... February 28, 2017 News solutions for biometrics, ... ... from 14 to 16 March, Materna will present its ... how seamless travel is a real benefit for passengers. To ... to their passenger touch point solutions to take passengers through the ...
Breaking Biology News(10 mins):
(Date:3/23/2017)... , March 23, 2017  SeraCare ... to global in vitro diagnostics manufacturers and ... the industry,s first multiplexed Inherited Cancer ... testing by next-generation sequencing (NGS). The Seraseq™ ... developed with input from industry experts to ...
(Date:3/23/2017)... -- NetworkNewsWire Editorial Coverage  ... Cancer remains one of the ... care systems, in terms of costs and resources. However, as ... development of innovative and efficient therapies that demonstrate higher chances ... of cancer treatments, a growing number of patients receiving immuno-oncology ...
(Date:3/22/2017)... Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN), today announced a major research ... GSK to generate genetic sequence data from the 500,000 volunteer ... researchers to gain valuable insights to support advances in the ... and life threatening diseases. ... Genetic evidence has revolutionized scientific discovery ...
(Date:3/22/2017)... Oramed Pharmaceuticals Inc. (NASDAQ: ... ), a clinical-stage pharmaceutical company focused on ... today that Dr. Miriam Kidron , Oramed,s ... "Oral Insulin for Diabetes Treatment: Bypassing the Roadblock," ... Peptide Therapeutics (OPT) Boston Conference in Cambridge, ...
Breaking Biology Technology: