Navigation Links
Discovery clarifies role of peptide in biological clock

A biologist at Washington University in St. Louis is giving the VIP treatment to laboratory mice in hopes of unraveling more clues about our biological clock.

VIP is not "very important person," but vasoactive intestinal polypeptide (VIP), a neuropeptide originally found in the gut, that is also made by a specialized group of neurons in the brain.

Erik Herzog, Ph.D., Washington University assistant professor of Biology in Arts & Sciences, has discovered that VIP is needed by the brain's biological clock to coordinate daily rhythms in behavior and physiology. Neurons in the biological clock, an area called the suprachiasmatic nucleus (SCN), keep 24-hour time and are normally synchronized as a well-oiled marching band coming onto the field at half time. Herzog and graduate student, Sara Aton, found that mice lacking the gene that makes VIP or lacking the receptor molecule for VIP suffer from internal de-synchrony. When they recorded the electrical activity of SCN neurons from these mice, they found that many had lost their beat while others were cycling but unable to synch to each other.

But when Herzog and Aton added VIP to the mice cells, the synchronicity was restored, showing that VIP couples pacemaker cells and drives rhythms in slave cells.

"VIP between SCN neurons is like a rubber band between the pendulums of two grandfather clocks, helping to synchronize their timing. Some researchers had proposed that knocking out VIP or the receptor for it stopped the clock," Herzog said. "We've found that the biological clock is still running, but its internal synchrony is uncoordinated. This causes irregular patterns of sleep and wake, for example."

The study was published on-line in Nature Neuroscience on March 6, 2005. Herzog's work is funded by the National Institutes of Health.

"In a light-dark schedule, these mice looked normal, but as soon as you leave off the lights, they reveal their internal de-synchrony," he sai

Source:Washington University in St. Louis

Page: 1 2

Related biology news :

1. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
2. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
3. UCSD Discovery Shows How Embryonic Stem Cells Perform Quality Control Inspections
4. Discovery Could Lead To Novel Approaches In HIV Treatment
5. Discovery Promises Simpler Therapy for Sickle Cell Disease
6. Discovery may lead to better Candidiasis drug
7. Protein Discovery Could Unlock The Secret To Better TB Treatment
8. Eliminate Data Analysis Bottlenecks in Drug Discovery
9. Discovery of New Dopamine Action May Yield Alternative Psychiatric Drugs
10. Discovery could be key to bioterrorism defense
11. Discovery of an American salamander where it shouldnt be: Korea
Post Your Comments:
TAG: Discovery clarifies role peptide biological clock

(Date:9/10/2015)... , Sept. 10, 2015 Report ... New Study Reveals Selling Opportunities and Revenue Prospects ... the future of biologics, especially new drug classes? ... will stay ahead with exclusive market data and ... explore trends, developments, results, opportunities and sales predictions. ...
(Date:9/9/2015)... VANCOUVER, British Columbia , Sept. 9, 2015 ... achieved numerous organizational and solution-based milestones, furthering the ... the perils of online fraud. NuData ... key in enhancing the company,s growth cycle. The ... machine learning to determine good user behavior from ...
(Date:9/2/2015)... , Sept. 2, 2015 Security ... concern for enterprises, banks, government organizations, telecommunications, hospitals, ... numeric keypads were previously being used to prevent ... of two-factor authentication, wherein individuals could gain access ... different components, such as hardware devices and numeric ...
Breaking Biology News(10 mins):Next-Generation Biologics: R&D, Industry and Market Forecasts 2015-2025 2Next-Generation Biologics: R&D, Industry and Market Forecasts 2015-2025 3Next-Generation Biologics: R&D, Industry and Market Forecasts 2015-2025 4Next-Generation Biologics: R&D, Industry and Market Forecasts 2015-2025 5Next-Generation Biologics: R&D, Industry and Market Forecasts 2015-2025 6NuData Security Achieves Significant Milestones, Furthers Commitment to Providing Unparalleled Online Fraud Detection 2Global Biometrics Spending Market in the Government Sector 2015-2019 2Global Biometrics Spending Market in the Government Sector 2015-2019 3
... in India has risen in response to a 20-fold drop ... article in the Nov. 15 issue of Clinical Infectious Diseases, ... country has encouraged people to seek HIV treatment because of ... more than 5 million HIV-infected people living in India have ...
... people with compromised immune systems may be feasible ... who demonstrated their approach could protect against pneumocystis ... immune cells that HIV destroys in humans. The ... researchers, working in collaboration with researchers from the ...
... Researchers from Johns Hopkins have discovered the presence of ... These ion channels act like electrical wires and permit ... become all cell types of the body, to conduct ... selectively block some of these channels in implanted cells, ...
Cached Biology News:HIV mortality in India drops with introduction of generic antiretroviral therapy 2New vaccine platform may fight infections with causes from influenza to bioterrorism 2New vaccine platform may fight infections with causes from influenza to bioterrorism 3Stem cells' electric abilities might help their safe clinical use 2
(Date:10/1/2015)...  xG Health Solutions, a leading healthcare management ... platform for communication and collaboration with healthcare organizations. ... health plans improve the quality and efficiency of ... products and educational resources. "Our ... we know the process of re-engineering care delivery ...
(Date:10/1/2015)... -- Oramed Pharmaceuticals Inc. (NASDAQ: ORMP ... on the development of oral drug delivery systems, announced ... Aegis Growth Conference, taking place October 7-9, 2015 in ... of Oramed, will present a corporate overview on October ... 2015 Aegis Growth Conference Date: Thursday, October ...
(Date:10/1/2015)... ... ... Hearth in Potsdam, NY. and a member of the Masonry Heater Association of North ... northern New York. The masonry heater fireplace is beautiful, simple, and it burns a fraction ... the home comfortable but when it is below zero, their needs to be one fire ...
(Date:9/30/2015)... /PRNewswire/ - Resverlogix Corp. (the "Corporation") (TSX:RVX) today announced that, ... September 30, 2015, each of the five nominees proposed as ... August 17, 2015 were elected as directors.  Proxy voting results ... Withheld , % For , % WithheldDonald J. McCaffrey , ... , 0.40% Peter Johann , 32,990,226 ...
Breaking Biology Technology:xG Health Solutions Launches New Platform for Hospitals, Clinics and Health Plans 2Oramed to Present at the Aegis Capital Growth Conference 2Oramed to Present at the Aegis Capital Growth Conference 3The Masonry Heater Association of North America Receives News About A New York Couple Who Saved Considerable Money Heating Their Home With A Wood Fired Masonry Heater 2Resverlogix Announces Voting Results 2
... growth company of diversified businesses, ... Transportation Accessories Group has acquired ... zinc plating services. Chem-Chrome is ... has been a longtime processor ...
... Software, worldwide leader in e-document ... Fax and VSI-FAX(R) product families, ... 3.0. This new solution allows ... more efficiently, effectively, and economically ...
... nanoscale device developed by a University of Wisconsin-Madison Engineering ... electrons in such devices as laptop computers and provide ... This device will allow researchers to study ... heat dissipation on single electron transport in transistors. ...
Cached Biology Technology:Cool Computers 2Cool Computers 3