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Discovering the first steps in transcription-coupled repair

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"This new mechanism means that transcription-coupled repair is much more efficient than other processes for resolving stalled transcription, since it can operate with RNAPII still in place, so that transcription to that point is not lost," says Cooper. "Remodeling would thus be the pathway of choice, with alternative methods available in a pinch. Only if all else fails would the RNAPII be destroyed, forcing transcription to start fresh."

In this first in a series of papers on the mechanisms of TCR, Cooper and her colleagues have shed early light not only on how the mysterious process of transcription-coupled repair works at the molecular level, but also on the underlying cause of the transcription defects that accumulate after birth in Cockayne Syndrome, which result in cell death leading to CS's characteristic neurological decline and wasting. Further work may provide insight into the processes of aging itself.


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Source:DOE/Lawrence Berkeley National Laboratory


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