Navigation Links
Discovering the first steps in transcription-coupled repair

it.

"This new mechanism means that transcription-coupled repair is much more efficient than other processes for resolving stalled transcription, since it can operate with RNAPII still in place, so that transcription to that point is not lost," says Cooper. "Remodeling would thus be the pathway of choice, with alternative methods available in a pinch. Only if all else fails would the RNAPII be destroyed, forcing transcription to start fresh."

In this first in a series of papers on the mechanisms of TCR, Cooper and her colleagues have shed early light not only on how the mysterious process of transcription-coupled repair works at the molecular level, but also on the underlying cause of the transcription defects that accumulate after birth in Cockayne Syndrome, which result in cell death leading to CS's characteristic neurological decline and wasting. Further work may provide insight into the processes of aging itself.


'"/>

Source:DOE/Lawrence Berkeley National Laboratory


Page: 1 2 3 4 5 6

Related biology news :

1. Discovering an ecosystem beneath a collapsed Antarctic ice shelf
2. A genes first kiss sets off that affair known as puberty
3. Love at first smell
4. Worlds largest rainforest drying experiment completes first phase
5. PCRM develops worlds first cruelty-free insulin assay
6. Expression Project for Oncology (expO) completes first phase of standardized gene expression analyses
7. World-first Living Donor Islet Cell Transplant A Success; Procedure Offers Promise For Diabetics
8. DuPonts first biologically derived polymer receives global recognition
9. Anti cancer virotherapy well tolerated in first human administration, research finds
10. Unlike other mammals, newborn dolphins and orcas stay active 24/7 during first months of development
11. The first impact factor for PLoS Biology ?13.9
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Discovering the first steps transcription coupled repair

(Date:10/15/2014)... 44th Rosenstiel Award for Distinguished Work in Biomedical Science ... mechanisms of genomic instability and its implications for the ... alumnus to win the Rosenstiel Award; the first, Rod ... is the Charles A. Janeway Professor of Pediatrics and ... investigator at the Howard Hughes Medical Institute at Boston ...
(Date:10/14/2014)... new study published in Cancer Research shows ... and colon cancers—can promote the development of skin cancers ... and survival of sun-damaged skin cells. , Previously considered ... proteins called sirtuins that help regulate genomic stability and ... SIRT6 helps repair DNA damage, which can lead to ...
(Date:10/14/2014)... questions is how to produce enough food to feed ... and Agriculture Organization of the United Nations predicts that ... years to feed a growing global population, and plants ... food production. Plants—grains, cereals, fruits, vegetables, and more—feed ... research must tap into our knowledge of how plants ...
Breaking Biology News(10 mins):Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer 2Building a bridge from basic botany to applied agriculture 2Building a bridge from basic botany to applied agriculture 3
... Northern Arizona University and the National Center for Ecological ... circuit theory to predict gene flow across landscapes. Their ... the best spots for wildlife corridors, which are crucial ... similarities between circuit theory and ecological connectivity, said Brad ...
... and Post-It Notes Three things that started out as obscure ... will the next idea to stick with modern society look ... a humble lizard, according to a University of Calgary biologist ... to virtually any surface, including glass., Unlike most creatures, geckos ...
... University of the Basque Country (UPV/EHU), an in vitro culture ... reproduce the gene regulation that is expressed in these cancer ... patients. This in vitro culture model provides a simple tool ... factors regulating this expression, as well as a simple form ...
Cached Biology News:Model connects circuit theory to wildlife corridors 2Sticky questions tackled in gecko research 2It is important to demonstrate the influence of the microenvironment in the process of metastasis 2It is important to demonstrate the influence of the microenvironment in the process of metastasis 3
(Date:10/20/2014)... The report “Pharmacy Automation Systems ... and Labeling Systems, Table-top Counters) by End-user (Inpatient ... & Trends to 2019” analyzes and studies the ... America, Europe, Asia-Pacific, and the Rest of the ... 30 figures spread through 300 pages and in-depth ...
(Date:10/20/2014)... PARK, Calif. , Oct. 20, 2014 /PRNewswire/ ... today that the Company has signed a Notice ... of Regenerative Medicine (CIRM), effective October 1, 2014.  ... Clinical Development payments and the release of additional ... million CIRM grant award for clinical development of ...
(Date:10/20/2014)... 20, 2014  GenVec, Inc. (NASDAQ: GNVC ) ... Ph.D., from its board of directors effective on October 24, ... and served as its chairman from June 2006 to November ... and Corporate Governance and Audit Committees of the board.  ... decade of dedicated service to GenVec, and its stockholders," said ...
(Date:10/20/2014)... Earle Martin , Chief Executive ... Ellen Teplitzky, an experienced attorney specializing in business ... has joined the firm as Director of Legal ... NDA Partners provides legal services, including research, ... top law firms and their clients in cases ...
Breaking Biology Technology:Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 2Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 3Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 4Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 2Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 3Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 4Zola P. Horovitz To Retire From GenVec Board 2NDA Partners Appoints Ellen Teplitzky, JD as Director of its Legal Services Practice 2
... Syngenta today announced that it has acquired Georgia-based ... protection technology to the company,s portfolio. Circle One Global ... a toxin that can develop in crops such as corn ... , "The acquisition of this technology adds an important ...
... ... Biotechnology Laboratory, and support US and European power supplies. , ... Williamstown, NJ (PRWEB) June 11, 2009 -- ... box. The CS230000 and CS230001 both are new Biotechnology kits from A-WIT Technologies. Choose ...
... ... financial services offerings to further meet the needs of emerging businesses. ... on Demand - NSS partners with their clients acting as an outsourced ... Solutions team equips its clients with multiple game plans; a blue print ...
Cached Biology Technology:Syngenta Acquires Innovative Bio-Control Technology to Improve Usable Crop Yields 2Syngenta Acquires Innovative Bio-Control Technology to Improve Usable Crop Yields 3A-WIT Technologies Releases World's First Low Cost C Stamp(TM) Based Biotechnology Laboratory in a Box 2Next Stage Solutions Announces Three New Financial Services For Emerging Business 2Next Stage Solutions Announces Three New Financial Services For Emerging Business 3
Sheep polyclonal to Quinolone ( Abpromise for all tested applications). Antigen: Norfloxacin(N)conjugated to BSA...
...
...
... the 9, 10, 12, and 13 positions. It ... for the quantification of 9(S)-HODE by GC- or ... of linoleic acid in both plants and animals. ... an esterified component of membrane phospholipids and in ...
Biology Products: