Navigation Links
Discoveries by UAB and Florida scientists may help transplanted organs survive longer

Scientists may have found a way to dramatically slow organ transplant rejection by as much as several years.

That's the promising implication of an animal study carried out by researchers at the University of Alabama at Birmingham (UAB) and the University of Florida (UF) published in today's (May 2) issue of Proceedings of the National Academy of Sciences.

The research team reported that they have identified the biological pathway of a potent molecule that could delay rejection of transplanted organs by preventing blood-vessel deterioration.

"One of the principal problems for kidney transplantation is organ availability," said Mark A. Atkinson, Ph.D., a study co-author and director of the Center for Immunology and Transplantation Research at UF. "That occurs in part because after several years, people with kidney transplants often lose function of the organ. With about 60,000 people on the waiting list for a transplant, it would help immensely to find a way to reduce a patient's need for a second or third kidney."

The helpful molecule, IL-10, has anti-inflammatory, immunosuppressive and other properties that help keep blood vessels healthy. Chronic vascular rejection, characterized by thickening of the interior lining that eventually chokes off the blood supply, is a major cause of the loss of function in solid organ transplants.

The study, carried out in rat models, also showed that a single muscular injection of the molecule, interleukin-10 (IL-10), carried in a gene delivery vector, or mechanism, could provide long-term therapeutic effects.

Anupam Agarwal, M.D., director of the UAB Nephrology Research and Training Center and senior author of the report, said the group found that IL-10 was active through the heme oxygenase-dependent (HO-1) biological pathway between cells.

"We found that one dose of IL-10 delivered using a viral vector delays the vascular disease from occurring," Agarwal said. "If the HO-1 pat hway is blocked, the protective effects of IL-10 are lost. The delay in vascular disease shown in this study could ?after more research and possible clinical trials in human beings ?offer the benefit of at least several additional years of health for transplanted organs."

A key to the single-injection strategy, Atkinson said, "was the use of adeno-associated virus as a way to deliver IL-10 into the body, allowing sustained levels of the molecule to be persistently secreted into the blood stream.

The next step will be to evaluate the treatment to try to protect kidney transplants in non-human primates ?and if successful there, go on to clinical trials in humans, said Agarwal.


'"/>

Source:University of Florida


Related biology news :

1. Advancements In Genomics Foster Deep Sea Discoveries
2. Cousin of Asian super termite invades Florida
3. Searching the depths of the straits of Florida for disease cures
4. Research suggests fitness of Florida panthers improved by limited breeding with Texas animals
5. Quick identification needed to save Floridas citrus industry from devastating disease
6. Cigarette smoke blocks cell repair mechanism, University of Florida study shows
7. NASA satellite data helps assess the health of Floridas coral reef
8. Florida Tech explores microalgae for biofuel
9. Wisconsin scientists grow critical nerve cells
10. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
11. UAB scientists discover the origin of a mysterious physical force
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2018)... , ... August 30, 2018 , ... ... residence times as a component of drug discovery programs. Longer-target engagement can result ... times are low throughput, require expensive instrumentation, or require the alteration of the ...
(Date:8/29/2018)... SAN JOSE, Calif. (PRWEB) , ... August 28, ... ... leader in cluster and cloud infrastructure automation software, announced that Data In Science ... , The HudsonAlpha Institute for Biotechnology is a non-profit genomics and ...
(Date:8/29/2018)... , ... August 29, 2018 ... ... validates first non-invasive technology to identify specific chromosomal abnormalities using morphological assessment ... Ovation Fertility and Australia-based Life Whisperer suggests that artificial ...
Breaking Biology News(10 mins):
(Date:9/22/2018)... (PRWEB) , ... September 20, 2018 , ... ... technologies and development solutions for drugs, biologics and consumer health products, today announced ... Relevant Today: Lipid-Based Drug Delivery in Modern Pharmaceutical Development,”. The one-day event is ...
(Date:9/15/2018)... ... ... Nationally recognized public accounting and consulting firm Cherry Bekaert LLP (“the Firm”) ... on her appointment to Launch Tennessee’s Board of Directors. , Patrick has ... Firm’s Nashville practice in December 2017 . In this role, she oversees the execution ...
(Date:9/12/2018)... ... September 11, 2018 , ... ... American Association of Feline Practitioners Conference (AAFP) later this month. The ... stem cell therapy for the treatment of chronic kidney disease in felines at ...
(Date:9/7/2018)... ... September 05, 2018 , ... Now available on live stream, the NanoScientific ... Sept. 19, 2018. With a panel of industry leaders from Harvard, Cornell, RPI, IBM, ... industry insights from experts in the field. Register today to be a part ...
Breaking Biology Technology: