Navigation Links
Diabetic nerve therapy shows 'striking' results

Research into a new treatment for nerve damage caused by diabetes could bring relief to millions of diabetic patients, say experts.

The treatment might also reduce the number of amputations of toes and feet if early effects on nerve protection and regeneration are borne out long-term. Nerve disease in diabetes is the major cause of non-traumatic lower limb amputations in Europe and North America.

Scientists at The University of Manchester, working with colleagues at American biotech firm Sangamo BioSciences Inc, have discovered a way of stimulating genes that prevent nerve damage caused by the disease.

Professor David Tomlinson, who is leading the research in Manchester, says the study has massive potential for the management of diabetic neuropathies or nerve disorders.

"Diabetic neuropathy is a major problem in insulin-dependent diabetes, particularly in patients who have had the disease for a period of time," said Professor Tomlinson, who is based in the University's Faculty of Life Sciences.

"This approach to gene therapy is quite different to previous attempts at treatment as we do not inject a gene that produces a 'foreign' copy of a therapeutic protein. This is the normal approach and has problems from immunological side-effects.

"Instead, we turn on the patient's own gene to produce a natural version of this therapeutically beneficial protein. The most significant advantage of this is that the protein is made as if the patient's body had made it naturally.

"Our study has shown that a single treatment with a DNA-binding protein protected against nerve damage that in humans can lead to limb loss."

The results of the pre-clinical studies were recently presented to the American Diabetes Association in California and the first phase of clinical trials has now begun.

An estimated 50 per cent of patients with long-term diabetes develop some form of neuropathy that can cause numbness and sometimes
'"/>

Source:University of Manchester


Page: 1 2

Related biology news :

1. World-first Living Donor Islet Cell Transplant A Success; Procedure Offers Promise For Diabetics
2. Wisconsin scientists grow critical nerve cells
3. Clam embryo study shows pollutant mixture adversely affects nerve cell development
4. Zebrafish may hold key to understanding human nerve cell development
5. New component of the brakes on nerve regeneration found
6. Cerebral navigation: How do nerve fibers know what direction to grow in?
7. Molecular messengers perform a crucial role in the ability of injured nerve cells to heal themselves
8. Malfunctioning bone marrow cells sabotage nerve cells in diabetes
9. UIC researchers show protein routes messages in nerve cells
10. Researchers find molecule that inhibits regrowth of spinal nerve cells
11. Gradient guides nerve growth down spinal cord
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Diabetic nerve therapy shows striking results

(Date:7/23/2014)... Defense recently awarded the STEMPREP Project at Southern ... its goal of increasing the number of minorities ... middle school students for the two-summer classroom phase ... students with summer opportunities at research labs. , ... School of Education and Human Development, boasts an ...
(Date:7/23/2014)... North Carolina State University shows that urban "heat islands" ... States. One factor is that researchers have found warmer ... gloomy scale insect a significant tree pest ... times more adult gloomy scales on urban trees. , ... the gloomy scale in cities, and now we know ...
(Date:7/23/2014)... Honey bees, especially the young, are highly sensitive ... together to maintain temperatures within a narrow range. Recently ... at Tufts University,s School of Arts and Sciences, is ... heat within a hive in process similar to how ... vessels and skin. , "This study shows how ...
Breaking Biology News(10 mins):Department of Defense awards $2.6 million grant to SMU STEM program for minority students 2Urban heat boosts some pest populations 200-fold, killing red maples 2Urban heat boosts some pest populations 200-fold, killing red maples 3How honey bees stay cool 2
... researchers at The Johns Hopkins University School of Medicine reveal ... papers appear in the March issue of The Journal ... opening, many ion channels spontaneously close by inactivation, a process ... channels is important for a variety of biological processes, including ...
... Illinois study touts the benefits of soluble fiberfound in ... the inflammation associated with obesity-related diseases and strengthens the ... immune cellsthey go from being pro-inflammatory, angry cells to ... infection," said Gregory Freund, a professor in the U ...
... NEW ORLEANS, LA. Minerals Management Service (MMS) ... biologists have set sail to learn more about the ... Mexico. The first of the research cruise,s three legs ... is underway. The first and second legs of ...
Cached Biology News:An apple a day? Study shows soluble fiber boosts immune system 2An apple a day? Study shows soluble fiber boosts immune system 3MMS and NOAA scientists study prey of Gulf of Mexico sperm whales 2
(Date:7/23/2014)... Heroic worldwide conservation efforts have made great strides in ... in China, there are over 65 giant panda reserves ... But despite these efforts, just 1596 pandas remain in ... and zoos hope to save the panda by improving ... to the wild. Just how are these high-profile programs ...
(Date:7/23/2014)... Filippov (MIPT and Russian Quantum Center at Skolkovo) ... Republic, and the Institute of Physics in Bratislava, ... entanglement of particles passing through an amplifier and, ... Details are provided in an article published in ... preprint). , Quantum entangled particles are considered to ...
(Date:7/23/2014)... at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR), the Vienna University ... have succeeded in embedding nearly perfect semiconductor crystals ... of producing hybrid nanowires, very fast and multi-functional ... chip in the future. The research results will ... . , Nano-optoelectronics are considered the cornerstone of ...
(Date:7/23/2014)... 23, 2014 /PRNewswire-iReach/ -- Think Drinks are a neuroscience-backed ... long term. They are the first functional focus beverage ... as an alternative to the temporary fix associated with ... on July 29, 2014, with hopes to raise $50,000 ... Photo - http://photos.prnewswire.com/prnh/20140723/129697 Think ...
Breaking Biology Technology:Scientists find way to maintain quantum entanglement in amplified signals 2Scientists find way to maintain quantum entanglement in amplified signals 3Scientists find way to maintain quantum entanglement in amplified signals 4A crystal wedding in the nanocosmos 2truBrain Neuroscientists To Launch More Effective, Healthier Alternative To Energy Drinks On Indiegogo 2
... scientists has determined the structure of the chlorophyll molecules in ... The team,s results one day could be used to build ... to electrical energy. A research paper about the discovery ... Proceedings of the National Academy of Sciences . , The ...
... 4 Meso Scale Diagnostics, LLC. (MSD) confirmed today ... the first identified case of infection with the 2009 ... Influenza Test, which is being developed under a contract ... is the investigational device referred to in the CDC,s ...
... May 4 Circ Pharma Limited ("Circ Pharma") ... have entered into a,Development Agreement to develop a ... to moderately severe pain. , ... delivery,technology enabling once daily dosing. Circ,s technology provides ...
Cached Biology Technology:Scientists determine the structure of highly efficient light-harvesting molecules in green bacteria 2Scientists determine the structure of highly efficient light-harvesting molecules in green bacteria 3Scientists determine the structure of highly efficient light-harvesting molecules in green bacteria 4Scientists determine the structure of highly efficient light-harvesting molecules in green bacteria 5Meso Scale Diagnostics' Point of Care Influenza Test Led to the First Identification of A(H1N1) Swine Flu Infection 2Circ Pharma Limited Enters Into Development Agreement for Chrono Tramadol With Elan Corporation Plc 2
... Certified USDA Research Registered OLAW Assured AAALAC ... AALAS Certified Technicians Documentation ... Upon Request Focus CRP is ... your custom immunology service needs. We ...
Applications: Western blotting ...
... data entry by collecting data from any ... Collect is extremely easy to use ... data entry. An excellent solution for ... spectrophotometers, force gauges, digital calipers, bar code ...
One unit is equal to 10Kb (insert DNA + vector). The final cost will increase or decrease according to the final assembled genome size. The price does not include genome annotation....
Biology Products: