Navigation Links
Diabetic nerve therapy shows 'striking' results

Research into a new treatment for nerve damage caused by diabetes could bring relief to millions of diabetic patients, say experts.

The treatment might also reduce the number of amputations of toes and feet if early effects on nerve protection and regeneration are borne out long-term. Nerve disease in diabetes is the major cause of non-traumatic lower limb amputations in Europe and North America.

Scientists at The University of Manchester, working with colleagues at American biotech firm Sangamo BioSciences Inc, have discovered a way of stimulating genes that prevent nerve damage caused by the disease.

Professor David Tomlinson, who is leading the research in Manchester, says the study has massive potential for the management of diabetic neuropathies or nerve disorders.

"Diabetic neuropathy is a major problem in insulin-dependent diabetes, particularly in patients who have had the disease for a period of time," said Professor Tomlinson, who is based in the University's Faculty of Life Sciences.

"This approach to gene therapy is quite different to previous attempts at treatment as we do not inject a gene that produces a 'foreign' copy of a therapeutic protein. This is the normal approach and has problems from immunological side-effects.

"Instead, we turn on the patient's own gene to produce a natural version of this therapeutically beneficial protein. The most significant advantage of this is that the protein is made as if the patient's body had made it naturally.

"Our study has shown that a single treatment with a DNA-binding protein protected against nerve damage that in humans can lead to limb loss."

The results of the pre-clinical studies were recently presented to the American Diabetes Association in California and the first phase of clinical trials has now begun.

An estimated 50 per cent of patients with long-term diabetes develop some form of neuropathy that can cause numbness and sometimes pain and weakness in the hands, arms, feet and legs.

Currently, patients are treated with painkillers and antidepressants that do not treat the underlying nerve damage. Progression to amputation is not inevitable but is always a threat.

Problems may also occur in other organs, including the heart, kidneys, sex organs, eyes and digestive tract.

The incidence of diabetes, a condition in which the amount of glucose in the blood is too high, is increasing dramatically, with the World Health Organisation estimating that some 300 million people worldwide could be affected by 2025.

The causes of diabetic neuropathy are not fully understood but researchers investigating the effect of glucose on nerves believe it is likely to be a combination of factors.

Sangamo's Chief Medical Officer, Dr Dale Ando, said: "We have been greatly encouraged by Professor Tomlinson's data and have moved the programme into the clinic.

"The first phase of human trials will assess safety and examine the effects of a single treatment in one leg compared with a placebo treatment in the other leg."

The Diabetes and Glandular Disease Clinic in San Antonio, Texas, is involved in the clinical trials.

Dr Mark Kipnes, a clinical investigator for Sangamo and endocrinologist at the clinic, said: "Currently, there are no effective therapies available to treat this debilitating and frequent complication of diabetes and patients are generally prescribed painkillers to alleviate symptoms.

"We are excited to be involved in testing this novel approach that may potentially have a dramatic therapeutic effect in populations of patients already suffering from neuropathy and those that are at risk of developing it."


'"/>

Source:University of Manchester


Related biology news :

1. World-first Living Donor Islet Cell Transplant A Success; Procedure Offers Promise For Diabetics
2. Wisconsin scientists grow critical nerve cells
3. Clam embryo study shows pollutant mixture adversely affects nerve cell development
4. Zebrafish may hold key to understanding human nerve cell development
5. New component of the brakes on nerve regeneration found
6. Cerebral navigation: How do nerve fibers know what direction to grow in?
7. Molecular messengers perform a crucial role in the ability of injured nerve cells to heal themselves
8. Malfunctioning bone marrow cells sabotage nerve cells in diabetes
9. UIC researchers show protein routes messages in nerve cells
10. Researchers find molecule that inhibits regrowth of spinal nerve cells
11. Gradient guides nerve growth down spinal cord
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2016)... First quarter 2016:   , Revenues amounted ... quarter of 2015 The gross margin was 49% (27) ... the operating margin was 40% (-13) Earnings per share ... operations was SEK 249.9 M (21.2) , Outlook   ... M. The operating margin for 2016 is estimated to ...
(Date:4/26/2016)... , April 27, 2016 ... the  "Global Multi-modal Biometrics Market 2016-2020"  report to ... ) , The analysts forecast the ... CAGR of 15.49% during the period 2016-2020.  ... number of sectors such as the healthcare, BFSI, ...
(Date:4/15/2016)... 15, 2016  A new partnership announced today ... underwriting decisions in a fraction of the time ... and high-value life insurance policies to consumers without ... With Force Diagnostics, rapid testing (A1C, Cotinine and ... (blood pressure, weight, pulse, BMI, and activity data) ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... (PRWEB) , ... May 25, 2016 , ... Scientists at ... line options being tried for mesothelioma may be hampering the research that could lead ... research. Click here to read it now. , The team evaluated 98 ...
(Date:5/24/2016)... ... 24, 2016 , ... Cell therapies for a range of ... research at Worcester Polytechnic Institute (WPI) that yielded a newly patented method of ... The novel method, developed by WPI faculty members Raymond Page, PhD, professor of ...
(Date:5/23/2016)... ... May 23, 2016 , ... The need for blood donations in South Texas and across ... South Texas Blood & Tissue Center, blood donations are on the decline. In fact, donations ... are down 21 percent in South Texas in the last four years alone. , There ...
(Date:5/23/2016)... and LONDON , May 23, 2016 ... Frontage Boost Efficiency by 40% - Frontage Implement a ... Frontage Enforce Quality, Compliance and Traceability Within the Bioanalytical lab ... in the United States and ... be deployed across its laboratory facilities. In addition to serving as ...
Breaking Biology Technology: