Navigation Links
Diabetes researchers pioneer islet cell xenotransplantation in primate studies

ward and proves neonatal porcine islets can correct diabetes long-term in primates," said Drs. Korbutt and Rajotte.

"To meet the needs of the millions suffering from type 1 diabetes, we must find new donor sources to allow large-scale application of islet cell transplantation in humans," said Dr. Larsen. "While there is much work to be done these studies suggest that the rejection response to porcine islets can be surmounted."

"The next step is to prove that these neonatal porcine islet cells could become a source for human transplantation," said Dr. Rajotte. "It's hoped that within the next three to five years, we will be transplanting patients with pig islets once we prove that it is safe."

Using a relatively simple and reproducible method of obtaining large numbers of islets from neonatal pig pancreata developed at the U of A, the researchers then transplanted islets comprised of endocrine and endocrine precursor cells into the monkeys. In vivo, these cells have been shown to proliferate, differentiate and reverse hyperglycemia in immunodeficient diabetic mice and allogeneic out-bred pigs.

However, humans and Old World primates have naturally occurring antibodies that are directed against antigens that can cause hyperacute or acute humoral rejection. To combat that, the researchers administered an anti-IL-2 receptor and anti-CD154 (H106) antibody, while maintaining immunosuppression using sirolimus and belatacept (a second-generation high affinity derivative of CTLA4-Ig)9-11 on diabetic rhesus macaques transplanted with neonatal porcine islets.


'"/>

Source:University of Alberta


Page: 1 2

Related biology news :

1. FDA Approves New Drug to Treat Type I and Type II Diabetes
2. First North American Encapsulated Islet Transplant without Long-term Immune Suppression into a Patient with Type 1 Diabetes
3. Single-donor Islet Transplantation Procedure Shows Promise For Patients With Type 1 Diabetes
4. Precise Timing Enabled Pig-to-rat Transplants To Cure Diabetes
5. Diabetes hits 275 Australians each day as pandemic spreads
6. Diabetes research takes wing thanks to long-lived fruit fly
7. Diabetes slows nerve recovery after heart transplant
8. NYU researchers simulate molecular biological clock
9. Vital step in cellular migration described by UCSD medical researchers
10. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
11. UCSD researchers maintain stem cells without contaminated animal feeder layers
Post Your Comments:
(Date:2/5/2015)... PARK, North Carolina , 5. Februar ... 35. Jahr als spezialisiertes Logistikunternehmen und hat ... als einzige klinische Logistikfirma (Clinical Logistics Organization ... Kernbotschaft der neuen Kampagne lautet First ... Lieferungen. Foto: http://photos.prnewswire.com/prnh/20150205/173753 ...
(Date:2/5/2015)... FRANCISCO , January 28, 2015 ... Market Analysis, Size And Segment Forecasts To 2020 has ... global IR camera market is expected to reach USD ... by Grand View Research, Inc. IR cameras help identify ... and are expected to witness surging demand in medical ...
(Date:1/22/2015)... and Markets ( http://www.researchandmarkets.com/research/4trb7t/biometrics_a ) has announced the ... report to their offering. , The ... individual is who she/he is claiming to be, and for ... unique physical characteristics, such as fingerprint, hand or palm print, ...
Breaking Biology News(10 mins):Marken startet Kampagne mit Patienten im Mittelpunkt 2Marken startet Kampagne mit Patienten im Mittelpunkt 3IR Camera Market Worth $5.10 Billion By 2020: Grand View Research, Inc. 2IR Camera Market Worth $5.10 Billion By 2020: Grand View Research, Inc. 3Biometrics - A Global Market Overview 2Biometrics - A Global Market Overview 3
... chimp inflicted devastating injuries on a Connecticut woman, was ... humansas much as four-times stronger, some researchers believe. But ... so much stronger than we are? One possible explanation ... Indeed, biologists have uncovered differences in muscle architecture between ...
... many scientists believed were retinal stem cells are, in ... Research Hospital have found. If retinal stem cells could ... to restore sight to millions of people with blindness ... capable of producing large numbers of adult cells, such ...
... genetic engineering breakthrough that could help everyone from bed-ridden patients ... Prize winner Mario R. Capecchihave created a "switch" that allows ... stem cells to monitor muscle regeneration in a living mammal. ... or drug, that allows people to grow new muscle cells ...
Cached Biology News:The secret to chimp strength 2Eye cells believed to be retinal stem cells are misidentified 2Eye cells believed to be retinal stem cells are misidentified 3Stem cell breakthrough: Monitoring the on switch that turns stem cells into muscle 2
(Date:2/26/2015)... The Movement for Indefinite Life Extension ... extension technologies and awareness. The event is taking place ... March 21st 2015, in a live Google Hangout broadcast ... Founder of MILE, says, “Our lives are in our ... for Indefinite Life Extension is raising awareness about bio-sciences ...
(Date:2/26/2015)... CLEVELAND , Feb. 26, 2015 BioEnterprise ... biomedical companies have attracted more than $2 billion in ... from local and national investors, strategic sources, state – ... Over half of the $2 billion has been raised ... announcement comes on the heels of the BioEnterprise ...
(Date:2/26/2015)... RURO, Inc., a leading LIMS, RFID and sample ... latest update to the bestselling commercial-off-the-shelf sample management system. ... and easy method to gain better control of sample ... has enhanced the system’s support for those customers who ... records. , "FreezerPro has become the go-to system ...
(Date:2/26/2015)... OAKS, Calif. , Feb. 26, 2015 ... achieved Gold Partner status in Oracle PartnerNetwork. In attaining ... for its commitment to establish Oracle-related knowledge in delivering ... the challenges of joint customers. Originally developed ... researchers to rapidly zoom in and out of massive ...
Breaking Biology Technology:Indefinite Life Extension Activists Organize Online Demonstration 2Indefinite Life Extension Activists Organize Online Demonstration 3More Than $2 Billion Invested in Northeast Ohio Bioscience Start-Up Companies Since 2002 2More Than $2 Billion Invested in Northeast Ohio Bioscience Start-Up Companies Since 2002 3More Than $2 Billion Invested in Northeast Ohio Bioscience Start-Up Companies Since 2002 4RURO Releases FreezerPro® version 6.2 2Ceres Becomes Oracle PartnerNetwork Gold Level Partner 2Ceres Becomes Oracle PartnerNetwork Gold Level Partner 3Ceres Becomes Oracle PartnerNetwork Gold Level Partner 4
... On the surface, it looks like people are saying nothing in ... published blogs on the Internet using online services such as ... , ,Most blogs last as long as a New ... services by Perseus Development Corporation suggests that 20 percent ...
... Editors Note: Wisconsins Department of Workforce ... strengthening the states workforce. The department has several ... address workforce shortages and provide re-employment and re-training ... an interview with the Wisconsin Technology Network talks ...
... Recent reports indicate a domestic backlash is brewing against ... recent examples took place in late November, when Indiana's ... in India to upgrade the state's unemployment claims processing ... Dell announced it would bring its phone-based tech support ...
Cached Biology Technology:Who Gives a Blog? 2WTN Interview: Roberta Gassman 2WTN Interview: Roberta Gassman 3Overseas Outsourcing Brews Backlash 2
Request Info...
4-Hydroxy-3-nitrophenylacetyl hapten is conjugated to KLH (Keyhole Limpet Hemocyanin) lysine through amide bonds....
Estrogen Receptor (ER) Competitor Assay Kits Green for Estrogen Receptors-alpha and -beta (ER-Alpha and ER-Beta) are ideal for screening novel estrogen receptor binding compounds and endocrine disrup...
Human Aminopeptidase P2/XPNPEP2 Affinity Purified PAb ENTREZ GeneID: 7512...
Biology Products: