Navigation Links
Diabetes researchers pioneer islet cell xenotransplantation in primate studies

A team of researchers from the University of Alberta, the Yerkes National Primate Research Center of Emory University and the Emory Transplant Center has successfully transplanted insulin-producing neonatal porcine islet cells into monkeys, a procedure the researchers say represents a promising intermediate solution to the critical supply problem in clinical islet cell transplantation.

"Our work at the U of A and Emory, along with recent work at the University of Minnesota, is very exciting and shows that xenotransplantation in humans may soon be possible, thus solving the islet supply problem," says one of the study authors Ray Rajotte, a professor of Surgery at the University of Alberta.

The paper appeared in an advanced on-line publication of Nature Medicine, February 26, entitled "Long-term survival of neonatal porcine islets in non-human primates by targeting co-stimulation pathways." The work follows on the heels of similar work published last week by University of Minnesota researchers; those researchers used islets isolated from adult pig pancreases.

Neonatal islets were produced in Edmonton using a procedure Drs. Greg Korbutt and Rajotte developed in 1995. The pig islets were sent to the Yerkes Research Center for transplantation into diabetic rhesus macaques using an anti-rejection protocol developed by Drs. Christian Larsen and Kenneth Cardona of the Yerkes Research Center and the Emory Transplant Center. The isolation method developed by the U of A researchers is simple and reproducible with the neonatal pig islets having some growth potential post-transplant, considered a major advantage over adult pig islets.

The diabetic animals were treated with a CD28/CD154 co-stimulation blockade-based immunosuppressive regimen, and achieved sustained insulin independence (median survival >140 days with one animal now at 300 days) without evidence of porcine endogenous retrovirus (PERV) dissemination. "This represents a major step for
'"/>

Source:University of Alberta


Page: 1 2

Related biology news :

1. FDA Approves New Drug to Treat Type I and Type II Diabetes
2. First North American Encapsulated Islet Transplant without Long-term Immune Suppression into a Patient with Type 1 Diabetes
3. Single-donor Islet Transplantation Procedure Shows Promise For Patients With Type 1 Diabetes
4. Precise Timing Enabled Pig-to-rat Transplants To Cure Diabetes
5. Diabetes hits 275 Australians each day as pandemic spreads
6. Diabetes research takes wing thanks to long-lived fruit fly
7. Diabetes slows nerve recovery after heart transplant
8. NYU researchers simulate molecular biological clock
9. Vital step in cellular migration described by UCSD medical researchers
10. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
11. UCSD researchers maintain stem cells without contaminated animal feeder layers
Post Your Comments:
(Date:7/11/2014)... University of Chicago is creating a new professorship ... the University,s Institute for Molecular Engineering and the ... donation from the Millicent and Eugene Bell Foundation., ... reside within the Institute for Molecular Engineering. That ... project at the MBL,s Eugene Bell Center for ...
(Date:7/11/2014)... Shenzhen, China Researchers from Salk Institute for Biological ... time evaluated the safety and reliability of the ... a new method, TALEN-HDAdV, which could significantly increased ... (hiPSC). This study published online in Cell ... for stem cell-based gene therapy. , The combination ...
(Date:7/11/2014)... 2014 The increased risk of kidney injury related ... fluids reflects the mass of HES molecules, according to ... journal of the International Anesthesia Research Society (IARS). , ... effect of HES on cultured human renal proximal tubule ... Wunder and colleagues of University Hospital Wrzburg, Austria. ...
Breaking Biology News(10 mins):New professorship in tissue engineering links molecular engineering, marine biology 2A new genome editing method brings the possibility of gene therapies closer to reality 2In lab studies, hydroxyethyl starch has direct harmful effects on kidney cells 2
... . . . With a network ... seismic activity, traffic, bacteria on beaches, water levels and ... to expand. Sensorpedia, developed three years ago by Oak ... first responders, individuals and communities with online sensor data ...
... ARBOR, Mich. Why do some diseases affect only ... of Michigan have found neural tissue contains imbalanced levels ... a debilitating childhood movement disorder. Known as ... movements or abnormal postures. It,s caused by a mutation ...
... 1. Discover the latest in Earth and Space Sciences ... findings in the Earth and space sciences in Foz do ... the meeting, which takes place from 8 to 12 August, ... 2010 Haiti and Chile earthquakes, extreme weather events in the ...
Cached Biology News:Story tips from the US Department of Energy's Oak Ridge National Laboratory -- June 2010 2Neural tissue contains imbalanced levels of proteins, U-M study finds 22010 Meeting of the Americas, Brazil: News media registration open 22010 Meeting of the Americas, Brazil: News media registration open 32010 Meeting of the Americas, Brazil: News media registration open 4
(Date:7/10/2014)... 10, 2014 Product and process ... low abundance and are often “lost in the ... , Join presenters Dr. Rowel Tobias, Senior Scientist, ... Anders, Head of Quality at Nanotherapeutics, Inc., to ... can speed detection and quantitation while achieving the ...
(Date:7/10/2014)... (PRWEB) July 10, 2014 Terascala, the ... announced that Alan Swahn, a former vice president of ... team as vice president of marketing. Terascala’s software when ... and NetApp create the highest performance and most reliable ... appointed to guide Terascala’s channel expansion and broaden its ...
(Date:7/10/2014)... Angeles, CA (PRWEB) July 10, 2014 ... and Bioanalytical techniques during 18-20 August, 2014 at Double ... critically review the recent developments in Analytical & Bioanalytical ... the globe. , Speaking on this occasion, Dr. Srinubabu ... Analytica Acta conference is a remarkable one in ...
(Date:7/10/2014)... , July 10, 2014  Franciscan St. ... of capnography for respiratory monitoring outside the ... healthcare leaders in embracing state-of-the-art patient safety ... patients are breathing and can alert medical ... measuring the amount of carbon dioxide the ...
Breaking Biology Technology:Novel Ms Techniques Speed Detection of Biopharmaceutical Product and Process Impurities, New Webinar Hosted by Xtalks 2Terascala Expands Executive Team 2Terascala Expands Executive Team 3A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2
... have pleaded guilty in Milwaukee to charges of criminal ... $6 million in counterfeit Rockwell Automation computer ... Alice Fisher for the Criminal Division and U.S. Attorney ... announced that Robert Koster of Jonesboro, Ark. pleaded ...
... of digital everything, print still captures the imagination of consumers ... , ,There's no clearer example than Blurb . I ... was no more than a brief PowerPoint deck. ... afternoon and Eileen unwound a vision for consumer-generated books that ...
... Jay Kouba, a 25-year veteran of the chemical and petroleum ... Energy Systems . , ,Virent, which recently entered into an ... Oil Co., is developing technologies that allow the renewable replacement ... of Metabolix, Inc. , a publicly traded Massachusetts bioscience ...
Cached Biology Technology:Two convicted of selling $6 million in counterfeit Rockwell software on eBay 2Blurb shows that print still captures imaginations 2Blurb shows that print still captures imaginations 3
Mouse monoclonal antibody raised against a partial recombinant CAPG. NCBI Entrez Gene ID = CAPG...
Mouse monoclonal antibody raised against a partial recombinant PDE2A. NCBI Entrez Gene ID = PDE2A...
...
... sample is a complex protein sample, ... when used with ReadyPrep 2-D starter ... sample can be used as a ... and protocol before using more difficult ...
Biology Products: