Navigation Links
Diabetes research takes wing thanks to long-lived fruit fly

The creation of an extraordinarily long-lived fruit fly by genetics researchers at the University of Rochester has led scientists down an unexpected new path in the fight against diabetes. The mutant fly is serving as a portal for understanding the factors that determine how nutrition and stress set the foundation for metabolic syndrome and diabetes, why diabetes occurs more frequently as people age, and indeed why people live as long as they do.

Dirk Bohmann, Ph.D., and Henri Jasper, Ph.D., are focusing on a cell signaling system that responds to stress and works in tandem with the insulin receptor that is central to diabetes. They recently received $2.5 million from the National Institutes of Health to conduct the next phase of their studies.

Why spend such funds on a fly that lives 40 percent longer than the average fly? Because of its promise for human health. New findings on aging, diabetes, and stress converge on the fly the team created. Later this month Bohmann will discuss the fly's implications for aging and health at a symposium in Sweden sponsored by the Wenner-Gren Foundations and also at the exclusive International Workshop on the Molecular and Developmental Biology of Drosophila, sponsored by the European Molecular Biology Organization, in Crete.

Bohmann and Jasper showed in 2003 that boosting the amount of a molecular signal known as JNK in a fruit fly allows the fly to live 85 days instead of 60, by spurring the fly to defend itself more aggressively against the oxidative stress that accelerates with aging. Such stress comes from the same chemical process that makes cars rust in the Rochester winter: Free-wheeling molecules known as free radicals zing through materials and run roughshod over anything in their way, including vital proteins and DNA. It's a major reason why generally our bodies falter as we age ?we're literally dinged to death by free radicals.

While scientists knew that JNK in a fly cranks up the anti-ox
'"/>

Source:University of Rochester Medical Center


Page: 1 2 3 4

Related biology news :

1. FDA Approves New Drug to Treat Type I and Type II Diabetes
2. First North American Encapsulated Islet Transplant without Long-term Immune Suppression into a Patient with Type 1 Diabetes
3. Single-donor Islet Transplantation Procedure Shows Promise For Patients With Type 1 Diabetes
4. Precise Timing Enabled Pig-to-rat Transplants To Cure Diabetes
5. Diabetes researchers pioneer islet cell xenotransplantation in primate studies
6. Diabetes hits 275 Australians each day as pandemic spreads
7. Diabetes slows nerve recovery after heart transplant
8. Columbia research lifts major hurdle to gene therapy for cancer
9. U of M researcher examines newly emerging deadly disease
10. NYU researchers simulate molecular biological clock
11. First atlas of key brain genes could speed research on cancer, neurological diseases
Post Your Comments:
(Date:7/2/2009)... and a domain unto themselves, quite apart from th...organisms. Many species live under extreme conditi...ared neither with bacteria nor with eukaryotes. Me...hane gas out of carbon dioxide and hydrogen. The u... the cofactor known as F0 or F420 which is the tin...
(Date:7/2/2009)...or of pathology and laboratory medicine at The Uni... has received a Career Development Award from the ...l support Smith,s research into the development of...g disorder, whose immune systems are resistant to ... 5,000 males born in the United States. , Throug...
(Date:7/2/2009)...ebrates its birth on the 4th of July, University o...ibbean coral reef nursery scientists will be celeb...ric Administration (NOAA) today announced that The... elkhorn coral recovery project, including Lirman,...support from the American Recovery and Reinvestmen...
(Date:7/1/2009)... today announced that Axel Ullrich, Ph.D., directo...x Planck Institute of Biochemistry in Germany, who...including Herceptin (trastuzumab) , is the winner ...Research. An independent committee of world-renow...ber 8 will receive a $100,000 prize during a cerem...
Breaking Biology News(10 mins):Rampant helper syndrome 2UT scientist receives hemophilia research award 2Nursery programs for corals receive TLC from NOAA this Independence Day 2Axel Ullrich named winner of 2009 Dr. Paul Janssen Award for Biomedical Research 2Accent Dual Mode Skin Tightening Laser is Latest Offering from Juva Skin Center 29743 1Accent Dual Mode Skin Tightening Laser is Latest Offering from Juva Skin Center 29743 2SCM Microsystems Introduces New Mobile Terminal for the German Electronic Health Card 29741 1SCM Microsystems Introduces New Mobile Terminal for the German Electronic Health Card 29741 2SCM Microsystems Introduces New Mobile Terminal for the German Electronic Health Card 29741 3New survey 3A More than half of US chronically ill adults skip needed care due to costs 29739 1New survey 3A More than half of US chronically ill adults skip needed care due to costs 29739 2New survey 3A More than half of US chronically ill adults skip needed care due to costs 29739 3New survey 3A More than half of US chronically ill adults skip needed care due to costs 29739 4New survey 3A More than half of US chronically ill adults skip needed care due to costs 29739 5Clemson researchers advance nanoscale electromechanical sensors 9167 1Clemson researchers advance nanoscale electromechanical sensors 9167 2
...06 issue of Current Anthropology sheds new light a...ons of whether or not they are a child,s biologica...0 percent of fathers are not the biological parent...t how this differs across cultures and to what ext...ological paternity. , "The issue of paternity--wh...
...c mineral called erionite was associated with a hi...ma, according to a study in the March 15 issue of ... Many cases of environment-related mesothelioma ha...lian plateau of Turkey. Blocks of erionite from vo...orage rooms for produce have been cut in the tuff....
...e social insects in the order Hymenoptera--which i...hanism for sex determination: Unfertilized eggs de...ales. But the development of an unfertilized egg i...sterious process. , One mystery has been the orig...ent that is ordinarily derived from the sperm afte...
...one wrong, researchers at the University of Califo... bacterial pathogens found in a number of troubles... their wrong-doing is carried out by disguising th...xon, Ph.D., Dean for Scientific Affairs and Profes...icine at the UCSD School of Medicine; Neal M. Alto...
Other Biology News:Exposure to volcanic mineral associated with increased mesothelioma incidence in Turkey 2Researchers now able to look deep into heart to view triggers of a heart's beat 2Researchers now able to look deep into heart to view triggers of a heart's beat 3UCSD team unmasks family of immune system invaders 2UCSD team unmasks family of immune system invaders 3
(Date:7/2/2009)...rstCall/ -- Lixte Biotechnology Holdings (OTC Bull...rs of the National Institute of Neurological Disor...stitute (NCI), National Institutes of Health and L...ances the effectiveness of two standard chemothera...search is being conducted under a Cooperative Rese...
(Date:7/1/2009)...identifies and removes systematic bias, noise and ...ould lead to more precise and reliable measurement...e future industrial applications. , Known as seq...he technique could also reduce the amount of exper...p distinguish true nanoscale phenomena from experi...
(Date:7/1/2009)...llular Dynamics International (CDI) and Roche ... existing agreement to test drug development candi... or damage to heart tissue. The two-year collabora...to bring promising therapies to patients faster. ...ied cardiomyocytes, created from induced pluripote...
(Date:7/1/2009)... Inc. ("Biocept"), an emerging leader in biotechno... Petree and M. Faye Wilson as Directors. , , "...d. Their experience will be invaluable to us as we...ephen M. Coutts, President and CEO. , , Ms. Wi...pany, a business management and strategic planning...
Breaking Biology Technology:Lixte Biotechnology Holdings' Lead Compound, LB-1.2, Enhances the Effectiveness of Standard Cancer Chemotherapy in Animal Models 2Lixte Biotechnology Holdings' Lead Compound, LB-1.2, Enhances the Effectiveness of Standard Cancer Chemotherapy in Animal Models 3New statistical technique improves precision of nanotechnology data 2New statistical technique improves precision of nanotechnology data 3New statistical technique improves precision of nanotechnology data 4Cellular Dynamics International and Roche Expand Existing Cardiotoxicity Screening Agreement 2Cellular Dynamics International and Roche Expand Existing Cardiotoxicity Screening Agreement 3Biocept, Inc. Announces Two New Director Appointments 2
..., , , Multiporator / Electroporator 25..., , Transformation Protocol ..., , , , , , , ...icroorganism , Corynebacterium glutamic..., Bacteria, gram positive, , ...
..., , , Multiporator / Electroporator 25..., , Transformation Protocol ..., , , , , , , ...icroorganism , Brucella abortus, ... Bacteria, gram negative, , ,...
..., , , Multiporator / Electroporator 25..., , Transformation Protocol ...15.503 04/2002 , , , ... , , Microorganism , ... , Cell type , Bacteria, g...
..., , , Multiporator , , , ... Transfection Protocol , Protocol N... , , , , , , , ,...20, mouse lymphoma B-cell line, , ...asmid pEGFP-N1 (in bidistilled H 2 O), ,...
Other Biology Technology:Corynebacterium glutamicum 2Brucella abortus 2Azotobacter vinelandii 2A 20 2
...he loxP-cm-loxP cassette is designed to allow ch... prokaryotic promoter gb2 driving the gene for chl...sion of the Em7 promoter. It mediates higher trans...omoter. A synthetic polyadenylation signal termina...
...his kit is designed for the fast and simple integr...any position (for the generation of transgenic mou...sette is designed to allow neomycin / kanamycin se...mbines a prokaryotic promoter (gb2) for expression...
Kit includes your choice of reagents for labeling 3 x 10 9 cells and EasySep magnet.
...pplication: For the efficient enrichment of functi...sue or cell culture. The isolated ER are useful fo...hway analysis. Metabolic abnornalities of ER inclu...ren, cystic fibrosis and many more ER protein rete...
Biology Products: