Navigation Links
Determining The Fate Of Cells In The Human Body

A study in the April issue (currently available online) of Nature Genetics establishes a model that may take scientists closer to understanding how cells in the human body determine their own fate.

Researchers, led by Anthony Firulli, Ph.D., associate professor of pediatrics and of medical and molecular genetics at the Indiana University School of Medicine, investigated the interaction of proteins responsible for Saethre-Chotzen Syndrome, a rare genetic disorder associated with limb abnormalities including webbed fingers and other developmental defects.

In the study, Dr. Firulli and colleagues studied how two proteins, Twist1 and Hand2, which are antagonists, couple to determine the number of digits on a hand, paw or wing, and whether these digits are webbed or not. In addition to limb abnormalities, these proteins are associated with cardiac and placental tissue defects. Twist1 mutations are encountered at high frequency in patients with Saethre-Chotzen Syndrome.

"By studying a disease in which things go wrong at the cellular level, we gain insight into how to correct these errors," said Dr. Firulli, who also is a molecular biologist at the medical school's Herman B Wells Center for Pediatric Research.

"From a pediatrics perspective -- there are many congenital defects - holes in the heart, cleft pallet, webbed hands -- which are outcomes of inappropriate molecular programs due to miscommunication at the cellular level. If we can understand what is going wrong, we may be able to correct these problems before birth," said Dr. Firulli.

Co-authors of the study are IU School of Medicine investigators Beth A. Firulli, Dayana Krawchuk, Victoria E. Centonze, Neil Vargesson, David M. Virshup, Simon J. Conway, Peter Cserjesi and Columbia University's Ed Laufer.

###

The study was funded by the National Heart, Lung and Blood Institute and the March of Dimes. Dr. Laufer's work is supported by the Howard Hughes Medical Inst itute.


'"/>

Source:Indiana University School Of Medicine


Related biology news :

1. Jump-starting T Cells In Skin Cancer
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. Transplantation Of Monkey Embryonic Stem Cells Reverses Parkinson Disease In Primates
4. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
5. Weill Cornell Research Reveals Secrets Of Trafficking Within Cells
6. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
7. Placenta Is A Rich Source Of Blood Stem Cells
8. UCSD Discovery Shows How Embryonic Stem Cells Perform Quality Control Inspections
9. Estrogen-like Component of Plastic Stimulates Growth of Certain Prostate Cancer Cells
10. Protein That Promotes Survival Of Stem Cells Might Be Key To Poor Leukemia Prognosis
11. Infants With Rare Genetic Disease Saved by Cord Blood Stem Cells
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/12/2016)... May 12, 2016 WearablesResearch.com , a ... the overview results from the Q1 wave of its ... wave was consumers, receptivity to a program where they ... a health insurance company. "We were surprised ... says Michael LaColla , CEO of Troubadour Research, ...
(Date:4/26/2016)... BANGALORE, India and LONDON ... Infosys Finacle, part of EdgeVerve Systems, a ... ), and Onegini today announced a partnership to ... banking solutions.      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ... banks to provide their customers enhanced security to ...
(Date:4/14/2016)... Israel , April 14, 2016 ... Authentication and Malware Detection, today announced the appointment of ... assumed the new role. Goldwerger,s leadership appointment ... on the heels of the deployment of its platform ... BioCatch,s behavioral biometric technology, which discerns unique cognitive and ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... June 24, 2016  Regular discussions on a range of ... between the two entities said Poloz. Speaking at ... Ottawa , he pointed to the country,s inflation target, ... government. "In certain ... institutions have common economic goals, why not sit down and ...
(Date:6/23/2016)... ... June 23, 2016 , ... Mosio, a leader ... “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with experienced clinical research professionals, ... providing practical tips, tools, and strategies for clinical researchers. , “The landscape of ...
(Date:6/23/2016)... 2016 A person commits a crime, and the ... track the criminal down. An outbreak of foodborne ... Administration (FDA) uses DNA evidence to track down the bacteria ... far-fetched? It,s not. The FDA has increasingly used a complex, ... foodborne illnesses. Put as simply as possible, whole genome sequencing ...
(Date:6/23/2016)... NEW YORK , June, 23, 2016  The ... students to envision new ways to harness living systems ... of Modern Art (MoMA) in New York ... more than 130 participating students, showcased projects at MoMA,s ... included Paola Antonelli , MoMA,s senior curator of ...
Breaking Biology Technology: