Navigation Links
Designing vaccines by computer

Having vaccines developed by computer may sound unnerving but the increasing role of computer modelling in the development of new vaccines could bring new products onto the market quicker, benefiting patients and saving pharmaceutical companies millions of pounds.

Researchers using informatics and computer modelling can help scientists to uncover and harness the hidden patterns in the wealth of DNA and protein sequences that modern bioscience generates and cut the number of compounds drug companies need to test when searching for new vaccines.

Researchers funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and working at the Edward Jenner Institute for Vaccine Research are using a very simple concept to help speed up the development of vaccines. They are studying fragments of 'foreign' proteins that have been shown by experiments to effectively trigger a response by the immune system. They look for common patterns in their sequences or structures and use the information to create a theoretical model of what is needed for one of these fragments to trigger an immune response. They can then employ computers to search for similar sequences in the thousands of sequences now available. When the search finds something promising it can be experimentally tested to see if it will trigger a response.

Dr Darren Flower, an international leader in this work, said, "A crucial feature of this search strategy is that we don't have to know what a foreign protein actually does in order to identify it as having fragments that that could make good vaccines. This approach has the potential to significantly reduce the number of proteins that we need to experimentally test to develop new vaccines to protect both humans and economically important livestock."

Professor Nigel Brown, BBSRC Director of Science and Technology, said, "Predictive biology, such as this work, has the potential to bring vaccines and medicines to patients faster,
'"/>

Source:BBSRC


Page: 1 2

Related biology news :

1. Live vaccines more effective against horse herpes virus
2. Improving the potential of cancer vaccines
3. Report focuses on challenges to unlocking future promise of vaccines
4. Medical experts: US unlikely to have enough vaccines to stop avian flu
5. Plant-derived vaccines safeguard against deadly plague
6. High-dose flu vaccines appear to safely boost immunity in elderly
7. Handling HPV vaccines and screening: The views of 100 authors
8. Protecting virus offers instant flu protection and converts flu infections into their own vaccines
9. Super enzyme may lead way to better tumor vaccines
10. Cellulose nanocrystal research could lead to new vaccines, computer inks
11. Cancer vaccines -- Taking a jab at cancer by stimulating the immune system
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Designing vaccines computer

(Date:9/30/2014)... do seedless watermelon, salmon, and strawberries all have in ... two sets of chromosomes and are diploid, these organisms ... sets of chromosomesseedless watermelon and salmon have 3 and ... While this might seem surprising, in fact most ... first discovered over a century ago, but only recently, ...
(Date:9/30/2014)... engineers, led by Clemson University associate professor Brian ... from the U.S. Department of Energy,s Experimental Program ... positive impact on South Carolina in the advancement ... , "Understanding the scientific and engineering needs for ... nuclear technologies is imperative if South Carolina is ...
(Date:9/30/2014)... German . FRANKFURT. ... in the world. Because they grow underground, people use trained ... of truffles is not only of interest to gourmets. A ... the Goethe University Frankfurt have discovered that the smell of ... trapped inside truffle fruiting bodies. , White truffles from the ...
Breaking Biology News(10 mins):Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 2Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 3Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 4Researchers get $5.25 million to advance nuclear technologies in South Carolina 2On the trail of the truffle flavor 2
... have designated a group of 13 ... (leishmaniasis), African Sleeping Sickness (African trypanosomiasis), ... Filariasis (elephantiasis), Onchocerciasis (river blindness), Drancunculiasis ... Ulcer, Trachoma). , These diseases have ...
... inserted into blood vessels, to better deliver beneficial genes ... of inflammation that often negates initial benefits. The new ... thin layer to bare metal surfaces, may have potential ... of metallic implants. , Cardiologists frequently treat heart disease ...
... An international team of scientists for the first time ... after it has encountered a single, new stimulus. The ... to peer within the living brain and explore short-term ... Galán, a leading author on the report who is ...
Cached Biology News:A New Era of Hope for the World's Most Neglected Diseases 2A New Era of Hope for the World's Most Neglected Diseases 3Bare metal stents deliver gene therapy to heart vessels with less inflammation in animal studies 2Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace 2Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace 3
(Date:10/1/2014)... September 30, 2014 Award winning ... announces four new-hosted collaboration bundles that combine ... high quality conferencing experiences for low, flat rate ... choose from, businesses have optimized solutions to meet ... include audio only minutes (1K, 5K, 10K ...
(Date:10/1/2014)... The U.S. Department of Labor has awarded ... as part of the Trade Adjustment Assistance Community College ... by the Department of Labor and Department of Education. ... E. Perez and Secretary of Education Arne Duncan announced ... to nearly 270 colleges across the country. , ...
(Date:9/30/2014)... in German . ... dots in a semiconductor layer. Quantum dots are small structures ... If a short laser pulse is fired at the photonic ... experiences a change in the electromagnetic field around it. This ... light by the dot. As soon as the refractive index ...
(Date:9/30/2014)... analog of one of nature,s most efficient light-harvesting ... led by Alejandro Briseno of the University of ... developing long-sought polymer architecture to boost power-conversion efficiency ... devices. , Briseno, with colleagues and graduate ... University and Dresden University of Technology, Germany, report ...
Breaking Biology Technology:SoundConnect Launches New Audio, Web and Video Bundles 2U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 2U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 3U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 4Ultrafast remote switching of light emission 2Blades of grass inspire advance in organic solar cells 2Blades of grass inspire advance in organic solar cells 3
... CARLOS, Calif., Sept. 16 Nektar,Therapeutics, (Nasdaq: NKTR ... scheduled to present at the upcoming UBS 2008 Global ... New York Hotel on,Tuesday, September 23, 2008 at 10:30 ... a Webcast through a link posted,on the Investor Relations, ...
... Claims, WASHINGTON, Sept. 16 The U.S. ... to the State of Kentucky to,help defray costs ... may prove actual innocence. Awarded by the DOJ,s ... of five competitive awards provided to,Arizona, Texas, Virginia, ...
... 16 PharmAthene, Inc.,(Amex: PIP ) a ... threats, announced today that David P. Wright,President and ... the,UBS Global Life Sciences Conference on September 25, ... Grant Hyatt hotel in New York., PharmAthene,s ...
Cached Biology Technology:Department of Justice Provides States With Funding for Testing in Postconviction Cases 2
Mouse monoclonal [6G11] to Cytohesin 1 + 2 ( Abpromise for all tested applications)....
HP 1 alpha Immunogen: Synthetic peptide between amino acids 1-100 of the human HP 1 alpha protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
... KLH-conjugated, synthetic peptide corresponding ... of mouse p19ARF. The ... acids 62-75. Clone 5-C3-1. ... by immunoblot. Stability ...
Request Info...
Biology Products: