Navigation Links
Designing vaccines by computer

Having vaccines developed by computer may sound unnerving but the increasing role of computer modelling in the development of new vaccines could bring new products onto the market quicker, benefiting patients and saving pharmaceutical companies millions of pounds.

Researchers using informatics and computer modelling can help scientists to uncover and harness the hidden patterns in the wealth of DNA and protein sequences that modern bioscience generates and cut the number of compounds drug companies need to test when searching for new vaccines.

Researchers funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and working at the Edward Jenner Institute for Vaccine Research are using a very simple concept to help speed up the development of vaccines. They are studying fragments of 'foreign' proteins that have been shown by experiments to effectively trigger a response by the immune system. They look for common patterns in their sequences or structures and use the information to create a theoretical model of what is needed for one of these fragments to trigger an immune response. They can then employ computers to search for similar sequences in the thousands of sequences now available. When the search finds something promising it can be experimentally tested to see if it will trigger a response.

Dr Darren Flower, an international leader in this work, said, "A crucial feature of this search strategy is that we don't have to know what a foreign protein actually does in order to identify it as having fragments that that could make good vaccines. This approach has the potential to significantly reduce the number of proteins that we need to experimentally test to develop new vaccines to protect both humans and economically important livestock."

Professor Nigel Brown, BBSRC Director of Science and Technology, said, "Predictive biology, such as this work, has the potential to bring vaccines and medicines to patients faster, and may also offer the potential to re-model existing vaccines to see whether they can regain their effectiveness against viruses and bacteria that have evolved resistance."


'"/>

Source:BBSRC


Related biology news :

1. Live vaccines more effective against horse herpes virus
2. Improving the potential of cancer vaccines
3. Report focuses on challenges to unlocking future promise of vaccines
4. Medical experts: US unlikely to have enough vaccines to stop avian flu
5. Plant-derived vaccines safeguard against deadly plague
6. High-dose flu vaccines appear to safely boost immunity in elderly
7. Handling HPV vaccines and screening: The views of 100 authors
8. Protecting virus offers instant flu protection and converts flu infections into their own vaccines
9. Super enzyme may lead way to better tumor vaccines
10. Cellulose nanocrystal research could lead to new vaccines, computer inks
11. Cancer vaccines -- Taking a jab at cancer by stimulating the immune system
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/18/2017)... SUNNYVALE, Calif. , April 18, 2017  Socionext Inc., a ... prototype of a media edge server, the M820, which features the ... face recognition software provided by Tera Probe, Inc., will be showcased ... and at the NAB show at the Las Vegas ... ...
(Date:4/11/2017)... Research and Markets has announced the addition of the ... ... grow at a CAGR of 30.37% during the period 2017-2021. ... prepared based on an in-depth market analysis with inputs from industry ... over the coming years. The report also includes a discussion of ...
(Date:4/5/2017)... , April 5, 2017 Today HYPR ... that the server component of the HYPR platform is ... providing the end-to-end security architecture that empowers biometric authentication ... HYPR has already secured over 15 million users across ... manufacturers of connected home product suites and physical access ...
Breaking Biology News(10 mins):
(Date:5/24/2017)... ... May 24, 2017 , ... ... implementation of CLEARAS Water Recovery’s Advanced Biological Nutrient Recovery (ABNR™) technology at its ... a $24 million plant upgrade to sustainably meet current and future nutrient discharge ...
(Date:5/24/2017)... ... May 24, 2017 , ... Patient ... developed with Wi-Fi connectivity to reduce the amount of wiring in a healthcare ... addition, compact mobile devices including infusion pumps, heart and hypertension monitoring, glucose monitoring, ...
(Date:5/23/2017)... Westminster, Colorado (PRWEB) , ... May 23, 2017 , ... ... amaranth as the most troublesome and difficult to control weed in 12 categories of ... found. , Almost 200 weed scientists across the U.S. and Canada participated in the ...
(Date:5/23/2017)... ... May 22, 2017 , ... ... row in the Aragon Research Globe™ for Corporate Learning, 2017. , Aragon Research ... and market demand, and effectively perform against those strategies. NetDimensions’ ranking as a ...
Breaking Biology Technology: