Navigation Links
Delaware scientists make significant advance in study of small RNAs

Science Foundation, the laboratories of Green and Meyers, which are housed at the Delaware Biotechnology Institute, overcame these obstacles to make a breakthrough in the study of small RNAs from Arabidopsis.

Prior to their work, scientists worldwide in a painstakingly slow and labor-intensive process had documented about 6,000 small RNAs from the plant.

Meyers had been sequencing RNAs in rice and Arabidopsis using MPSS when Green approached him about the possibility of sequencing small RNAs using the MPSS technology.

"We knew MPSS could work in sequencing small RNAs but we were not sure how interesting the outcome would be," Meyers said. "But, as soon as we received the first complete data set, we quickly saw that it was far richer and more complex than anyone had previously generated for this type of molecule."

As the project progressed, the laboratories sequenced about 2.2 million small RNAs from the seedlings and flowers of the plant and identified more than 75,000 different small RNA sequences.

"Not only does MPSS provide very deep coverage of small RNAs, but it also provides quantitative information," Green said, adding that "this allowed many highly regulated small RNAs to be identified."

In addition to the sheer number of sequences identified, Meyers said "the biggest surprise in the findings is the diversity." He said that their data indicated that the regions of the chromosomes where people had speculated there was not much transcriptional activity turned out to be sites of tremendous amounts of small RNA activity.

Green said the implications of their findings would have a vital impact on future research by both their laboratories and those at other institutions. "What we found is just the beginning because the ramifications go way beyond that," she said. "Much of the future excitement will result from different laboratories testing new ideas after looking at the data for their favorite genes or chr
'"/>

Source:University of Delaware


Page: 1 2 3

Related biology news :

1. University of Delaware researchers develop cancer nanobomb
2. Wisconsin scientists grow critical nerve cells
3. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
4. UAB scientists discover the origin of a mysterious physical force
5. Fox Chase Cancer Center scientists identify immune-system mutation
6. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
7. U-M scientists find genes that control growth of common skin cancer
8. UCLA scientists transform HIV into cancer-seeking missile
9. RNA project to create language for scientists worldwide
10. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
11. To control germs, scientists deploy tiny agents provocateurs
Post Your Comments:
(Date:7/24/2008)... 1. Fire suppression may have reduced carbon stora...ssion since the early twentieth century has caused...maller trees, and the density of stems growing on ...ave created thicker forests and are thought to acc...etter quantify changes in aboveground biomass, Fel...
(Date:7/23/2008)..., In a study of parasites living in three estuar...lifornia, researchers have determined that biomass... in some cases by more than 20 times. , Their fi...d biomedical implications, appear in this week,s i...mount of living matter that exists in a given habi...
(Date:7/23/2008)...(Santa Barbara, Calif.) - In a study of free-livin...Pacific coast of California and Baja California, a...rnia, Santa Barbara, the United States Geological ...at parasite biomass in those habitats exceeds that.... Their findings, which could have significant bio...
(Date:7/23/2008)..., Climate change will carry a price tag of billio...new series of reports from the University of Maryl...h (CIER). The researchers conclude that the costs ...ure. , Combining existing data with new analysis... impact of climate change on Colorado, Georgia, Ka...
Breaking Biology News(10 mins):AGU journal highlights -- July 23, 2008 2AGU journal highlights -- July 23, 2008 3AGU journal highlights -- July 23, 2008 4AGU journal highlights -- July 23, 2008 5AGU journal highlights -- July 23, 2008 6AGU journal highlights -- July 23, 2008 7AGU journal highlights -- July 23, 2008 8Parasites outweigh predators in Pacific Coast estuaries 2Parasites outweigh predators in Pacific Coast estuaries 3Study shows parasites outweigh predators 2Study shows parasites outweigh predators 3Costs of climate change, state-by-state: Billions, says UMD 2Costs of climate change, state-by-state: Billions, says UMD 3Costs of climate change, state-by-state: Billions, says UMD 4Irritating smells alert special cells NIH funded study finds 2393 1Irritating smells alert special cells NIH funded study finds 2393 2Irritating smells alert special cells NIH funded study finds 2393 3VIDEO from Medialink and The Childrens Hospital of Philadelphia 3A New Research Rules of the Road for Teens and Passengers 13354 1VIDEO from Medialink and The Childrens Hospital of Philadelphia 3A New Research Rules of the Road for Teens and Passengers 13354 2Gates Foundation Seeks Proposals for Innovative Global Health Research 1461 1Gates Foundation Seeks Proposals for Innovative Global Health Research 1461 2Gates Foundation Seeks Proposals for Innovative Global Health Research 1461 3Biological electron transfer captured in real time 3679 1Biological electron transfer captured in real time 3679 2
...ian cells infected with HIV-1 engage a primitive d... in plants and invertebrates. The research also re...rare form of immunity in vertebrate cells. However...ct itself provides some critical insight into a po...dentification of what might be a long sought after...
...itute, part of the National Institutes of Health, ...rmal tissue from human organs. Scientists searchin... the NCI database as a crucial point of reference ...many of the body,s major organs under normal condi...mpare the genes from their own biological samples ...
...he ever vigilant immune sentinels of its host. A l...des in nondividing cells and doesn’t produce any p...immune cells. If the virus targets one of the many...fe while latent. But some viruses, like the gamma-...which occasionally divide. The gamma-herpesvirus g...
...morrhagic fever have been reported in Angola. Of t...ts first 6 cases, bringing the number of affected ...western part of the country. , Mobile surveillance...esterday when vehicles were attacked and damaged b...ed, no surveillance teams were operational today i...
Other Biology News:Ancient immune defense mechanism is no match for HIV-1 2Gov't Creates Gene Database of Normal Human Tissues 2Gov't Creates Gene Database of Normal Human Tissues 3Gov't Creates Gene Database of Normal Human Tissues 4How A Latent Virus Eludes Immune Defenses 2How A Latent Virus Eludes Immune Defenses 3WHO suspends Marburg work, appeals for new funds 2
(Date:7/24/2008)...re/ -- The Global Probiotics Council,(GPC), a comm...ult Honsha,Co., Ltd., announced the two awardees w...rant for Probiotics Research (YIGPRO) today. The p...who will continue to contribute to,the advancement...United,States., Ajay S. Gulati, MD, an Assistant ...
(Date:7/24/2008)... Important Advance in Radiofrequency ...if., July 24 /- PEAK Surgical, Inc., ...tissue dissection system,based on a proprietary te...rug Administration has granted the company 510(k) ... use in general surgery. The PEAK Surgery System,c...
(Date:7/24/2008)...ire/ -- Sagent Pharmaceuticals, Inc.,a privately-...nced that it,has launched ceftazidime for injectio...m antibiotic. Sagent will offer ceftazidime in 1,a...ge vials. According to,IMS data, 2007 sales of inj...ximately $45.7 million., "Sagent is proud to be p...
(Date:7/24/2008)...swire-FirstCall/ -- United,Therapeutics Corporatio...lease its 2008 second quarter financial results be...., United Therapeutics will host a half-hour tele.... Eastern Time. The teleconference is accessible,b...rs dialing,1-706-679-8129. A rebroadcast of the te...
Breaking Biology Technology:Global Probiotics Council Announces First Awardees for New Young Investigator Grant for Probiotics Research 2Global Probiotics Council Announces First Awardees for New Young Investigator Grant for Probiotics Research 3Global Probiotics Council Announces First Awardees for New Young Investigator Grant for Probiotics Research 4PEAK Surgical Receives 510(k) Clearance to Market PEAK(R) Surgery System for Use in General Surgery 2PEAK Surgical Receives 510(k) Clearance to Market PEAK(R) Surgery System for Use in General Surgery 3PEAK Surgical Receives 510(k) Clearance to Market PEAK(R) Surgery System for Use in General Surgery 4Sagent Pharmaceuticals Launches Ceftazidime for Injection, USP 2
...ay introduced AutoBone, a clinical application tha...ians to remove the bone structure from diagnostic ...re hidden in traditional imaging views, which opti...ion to allow for less-invasive clinical procedures... software provides automated bone removal imaging ...
...ration , has built the supply chain industries fir...-compliant radio frequency identification (RFID) ...real-world environment. The RFID Lab is enabling R... tag placement and readability as they prepare for...fic data and scenarios, the RFID Lab is helping co...
...ty of Wisconsin - Madison spinout company that ut...ity funding from angel investors in Madison and th...stry leader in ultra-precision motion devices and ...ng. , ,nPoint possesses technologies to produce pr...objects at the sub-molecular level. These nanopos...
...ard UW-Madison professor Raj Veeramani and Menasha...hias stress the importance of innovation in todays...ovation Network (WIN) Foundation in northeast Wisc...sidiary of the Wisconsin Technology Council, which...logy advisor to the governor and the Legislature. ...
Other Biology Technology:RedPrairie Builds RFID Lab - Enables Real-World Testing 2WIN Northeast Wisconsin Chapter Launched for Regions Entrepreneurs 2
Porcine TNF-alpha/TNFSF1A ELISpot Development Module
5-bromo-4-chloro-3-indolyl b -D-galactopyranoside (X-Gal)
Attoglow Western Blot Analysis Kit is an ultra-sensitive chemiluminescent Western blot analysis kit developed by Biochain. It detects protein at attogram (10 -18 g) or yoctomole (10 -24 M) levels.
...ics software that has changed the way scientists a...n of BioNumerics allows for integration and powerf... for the characterization of organisms including s...rotein gels, HPLC, VNTR, MLST, SNP, fatty acid pro...
Biology Products: