Navigation Links
Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer

Deficiencies in the ability of cells to repair damaged DNA are associated with an increased risk of breast cancer, according to a new study in the January 19 issue of the Journal of the National Cancer Institute.

DNA repair is the system of defenses designed to protect the integrity of the genome. Studies have suggested that deficiency in cells' capacity for DNA repair contributes to the accumulation of DNA damage and accelerates the genetic changes involved in carcinogenesis.

To evaluate whether reduced DNA repair capacity in the nucleotide excision pathway that fixes DNA alterations known as bulky DNA adducts is associated with breast cancer risk, Regina M. Santella, Ph.D., of the Columbia University Mailman School of Public Health in New York, and colleagues analyzed cell lines generated from blood samples taken from pairs of sisters in which one sister had been diagnosed with breast cancer and the other had not.

They found that DNA repair capacity was lower in breast cancer patients than in the control subjects. Deficient DNA repair capacity was associated with a twofold increase in the risk of breast cancer. In addition, when the data were stratified into quartiles of DNA repair capacity, the risk of breast cancer was three times higher among women with the poorest DNA repair capacity compared with those with the highest.

"[T]hese data support the hypothesis that deficient DNA repair capacity is associated with susceptibility to breast cancer and may be a valuable in vitro biomarker to identify high-risk subjects, especially in familial breast cancer families," the authors write. "It is unclear at this time whether there are any interventions that could alter DNA repair capacity and what effect such interventions might have on risk."

In an editorial, Marianne Berwick, Ph.D., M.P.H., of the University of New Mexico in Albuquerque, and Paolo Vineis, M.D., M.P.H., of Imper ial College in London and the University of Torino in Italy, discuss the difficulties in designing studies of DNA repair capacity and the need for the development of better laboratory tests for such studies. "When DNA repair capacity can be measured easily and quickly, the scientific community will be able to clearly understand the role of DNA repair capacity in the development of cancer and possibly to develop interventions to reduce cancer incidence and mortality," they write.


'"/>

Source:Journal of the National Cancer Institute


Related biology news :

1. DNA Recombination and Repair—A New Twist to RecA Function
2. Increased risk of osteoporosis associated with gene that one in five people have
3. WHO Warns Of Increased Risk Of Vector-borne Diseases In Tsunami-affected Areas
4. Increased sensitivity to nerve signals keeps diabetes at bay
5. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
6. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
7. Gene Vaccine Protects Mice Against Development Of Her2/neu Breast Cancer
8. New Breast Cancer Test Could Save Lives
9. Breast Cancer May Be Uniquely Sensitive To Inhibitors Of PI3K Pathway
10. Breast-Cancer Risk Linked to Exposure to Traffic Emissions at Menarche, First Birth
11. Nanoparticle Breast Cancer Drug Approved by FDA
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/11/2016)... HANOVER, Germany , March 11, 2016 ... - Cross reference: Picture is available at AP Images ( ... scanner from DERMALOG will be used to produce the new refugee ... of other biometric innovations, at CeBIT in Hanover ... LF10 scanner from DERMALOG will be used to produce the new ...
(Date:3/10/2016)... March 10, 2016 --> ... research report "Identity and Access Management Market by Component ... and Governance), by Organization Size, by Deployment, by Vertical, ... by MarketsandMarkets, The market is estimated to grow from ... by 2020, at a Compound Annual Growth Rate (CAGR) ...
(Date:3/9/2016)... -- This BCC Research report provides an overview of ... (RNA Seq) market for the years 2015, 2016 and ... data analysis, and services. Use this report ... such as RNA-Sequencing tools and reagents, RNA-Sequencing data analysis, ... segment and forecast their market growth, future trends and ...
Breaking Biology News(10 mins):
(Date:5/26/2016)... Despite the volatility that continues to envelop the ... research on ActiveWallSt.com directs the investor community,s focus on the ... ), Cerus Corp. (NASDAQ: CERS ), Arrowhead Pharmaceuticals ... Inc. (NASDAQ: FPRX ). Register with us today ... On Wednesday, shares in Massachusetts ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... cuvettes are used in leading laboratories all over the globe. Their cute firefly ... addition to manufacturing awesome cuvettes, FireflySci makes spectrophotometer calibration standards that never require ...
(Date:5/25/2016)... ... May 25, 2016 , ... ... of fracture-specific plating options designed to address fractures of the distal tibia and ... , The Acumed Ankle Plating System 3 is composed of seven plate families ...
(Date:5/25/2016)... ... May 25, 2016 , ... Scientists at the University of ... tried for mesothelioma may be hampering the research that could lead to one good ... here to read it now. , The team evaluated 98 mesothelioma patients ...
Breaking Biology Technology: