Navigation Links
Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer

Deficiencies in the ability of cells to repair damaged DNA are associated with an increased risk of breast cancer, according to a new study in the January 19 issue of the Journal of the National Cancer Institute.

DNA repair is the system of defenses designed to protect the integrity of the genome. Studies have suggested that deficiency in cells' capacity for DNA repair contributes to the accumulation of DNA damage and accelerates the genetic changes involved in carcinogenesis.

To evaluate whether reduced DNA repair capacity in the nucleotide excision pathway that fixes DNA alterations known as bulky DNA adducts is associated with breast cancer risk, Regina M. Santella, Ph.D., of the Columbia University Mailman School of Public Health in New York, and colleagues analyzed cell lines generated from blood samples taken from pairs of sisters in which one sister had been diagnosed with breast cancer and the other had not.

They found that DNA repair capacity was lower in breast cancer patients than in the control subjects. Deficient DNA repair capacity was associated with a twofold increase in the risk of breast cancer. In addition, when the data were stratified into quartiles of DNA repair capacity, the risk of breast cancer was three times higher among women with the poorest DNA repair capacity compared with those with the highest.

"[T]hese data support the hypothesis that deficient DNA repair capacity is associated with susceptibility to breast cancer and may be a valuable in vitro biomarker to identify high-risk subjects, especially in familial breast cancer families," the authors write. "It is unclear at this time whether there are any interventions that could alter DNA repair capacity and what effect such interventions might have on risk."

In an editorial, Marianne Berwick, Ph.D., M.P.H., of the University of New Mexico in Albuquerque, and Paolo Vineis, M.D., M.P.H., of Imper
'"/>

Source:Journal of the National Cancer Institute


Page: 1 2

Related biology news :

1. DNA Recombination and Repair—A New Twist to RecA Function
2. Increased risk of osteoporosis associated with gene that one in five people have
3. WHO Warns Of Increased Risk Of Vector-borne Diseases In Tsunami-affected Areas
4. Increased sensitivity to nerve signals keeps diabetes at bay
5. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
6. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
7. Gene Vaccine Protects Mice Against Development Of Her2/neu Breast Cancer
8. New Breast Cancer Test Could Save Lives
9. Breast Cancer May Be Uniquely Sensitive To Inhibitors Of PI3K Pathway
10. Breast-Cancer Risk Linked to Exposure to Traffic Emissions at Menarche, First Birth
11. Nanoparticle Breast Cancer Drug Approved by FDA
Post Your Comments:
(Date:3/30/2015)... Mar. 26, 2015 Research and Markets ... "Global Gesture Recognition Market in Automotive Sector 2014-2018" ... forecast the Global Gesture Recognition market in Automotive Sector ... period 2013-2018. Gesture recognition is the ability ... gestures of an individual. Gesture recognition technology can be ...
(Date:3/24/2015)... 24, 2015 Research and Markets ( ... "Global Iris Recognition Market 2015-2019" report to their ... Recognition market to grow at a CAGR of 23.5 ... covers the present scenario and the growth prospects of ... To calculate the market size, the report considers the ...
(Date:3/24/2015)... --  NexID Biometrics LLC, whose spoof-mitigation technology boosts ... the beginning of shipments of version 2.0 of its ... based in Potsdam, N.Y. , is ... began here today at the Walter E. Washington Convention ... SDK boosts the accuracy rate range to 96.5 to ...
Breaking Biology News(10 mins):Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2
... medical information beyond what current newborn screening already provides? ... funded by the Eunice Kennedy Shriver National Institute of ... Human Genome Research Institute (NHGRI), both parts of the ... four grantees have been made in fiscal year 2013 ...
... a polyphenolic compound, is synthesized in several plants ... anti-inflammatory and anti-carcinogenic properties. Resveratrol exhibits neuroprotective effects ... ischemia, Huntington,s disease, Parkinson,s disease and Alzheimer,s disease. ... the effect of resveratrol in vascular dementia. Dr ...
... September 4, 2013 A study published today ... tool to accurately analyze extremely rare mitochondrial DNA (mtDNA) ... as well as aging. This approach, which relies on ... researchers explore mtDNA deletions as potential disease biomarkers. ...
Cached Biology News:NIH program explores the use of genomic sequencing in newborn healthcare 2NIH program explores the use of genomic sequencing in newborn healthcare 3NIH program explores the use of genomic sequencing in newborn healthcare 4Extremely rare mitochondrial DNA deletions associated with aging can be accurately detected with Droplet Digital PCR 2Extremely rare mitochondrial DNA deletions associated with aging can be accurately detected with Droplet Digital PCR 3
(Date:5/5/2015)... Calif. , May 5, 2015  23andMe, Inc., ... of the Lupus Research Study in collaboration ... individuals with systemic lupus erythematosus, more commonly known as ... genetics of lupus. The effort is also in collaboration ... Lupus Awareness Month in May. Approximately 1.5 ...
(Date:5/5/2015)... AVIV, Israel , May 5, 2015 /PRNewswire/ ... the Company was approved to continue trading on ... OTCQB Marketplace allows for a ... electronic broker-dealers. Investors can have real-time quotes and ... The OTCQB Marketplace includes U.S. ...
(Date:5/5/2015)... May 5, 2015  A group of biotechnology executives ... Coma Research Institute, a non-profit organization dedicated to providing ... suffering from disorders of consciousness.  ...   ... in which no voluntary actions can be initiated by ...
(Date:5/5/2015)... Calif. , May 5, 2015 CytomX, ... of cancer, today announced that Sean McCarthy , ... Credit Suisse Antibody Day in New York ... 6. Dr. McCarthy will present an overview of CytomX,s ... Probody drug conjugate programs. About CytomX Therapeutics ...
Breaking Biology Technology:23andMe Launches the Lupus Research Study in Collaboration with Pfizer Inc. 223andMe Launches the Lupus Research Study in Collaboration with Pfizer Inc. 3Tikcro Technologies Announces Approval to Continue Trading on OTCQB 2Biotechnology Executives and Medical Doctors Team Up to Tackle Coma and Disorders of Consciousness 2Biotechnology Executives and Medical Doctors Team Up to Tackle Coma and Disorders of Consciousness 3Biotechnology Executives and Medical Doctors Team Up to Tackle Coma and Disorders of Consciousness 4Biotechnology Executives and Medical Doctors Team Up to Tackle Coma and Disorders of Consciousness 5
... 9 Soligenix, Inc. (Soligenix or the Company), (OTC ... that Robert J. Rubin, MD, has been appointed to ... a distinguished career in the healthcare industry and government. ... of the national health policy and management consulting firm ...
... ... Caskey and Saul Tendler to its Scientific Advisory Board , ... Westlake Village, Calif. (PRWEB) October 9, 2009 -- Nanogea, a ... to announce today that Dr. C. Thomas Caskey and Dr. Saul Tendler have joined ...
... ... program and is opening the call for entries. Established in 2003, this prestigious awards ... that manifestly improve some facet of the R&D/drug development/clinical trial process. , ... Needham, MA (PRWEB) October 8, ...
Cached Biology Technology:Soligenix Appoints Robert J. Rubin, MD, to its Board of Directors 2Soligenix Appoints Robert J. Rubin, MD, to its Board of Directors 3Soligenix Appoints Robert J. Rubin, MD, to its Board of Directors 4Nanogea Announces New Scientific Advisory Board Members 2Nanogea Announces New Scientific Advisory Board Members 3The 2010 Bio-IT World Best Practices Call for Entries has been Released -- Highlight your Company's Excellence in Innovation 2The 2010 Bio-IT World Best Practices Call for Entries has been Released -- Highlight your Company's Excellence in Innovation 3
... yeast/leuconostoc overproducer ATP: D-hexose 6- ... One unit of HK will ... in 1 min at 25C ... of G6P-DH will oxidize 1 ...
Request Info...
... This product is expected to ... mammalian species but has not been ... single precipitin line against partially purified ... to react with all forms of ...
... Features Convenient platform for tube ... - 96 x 0.2ml V-bottom tubes ... Thermo-Tube Plates - Thermo-Fast® 96 Non-Skirted ... - 48 x 0.5ml Thermo-Tubes Multiple ...
Biology Products: