Navigation Links
Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems

Deficiencies of growth hormone and similar compounds may reduce cancer and kidney disease late in life, but also may lead to cartilage degeneration and impaired memory and learning ability, according to research at Wake Forest University Baptist Medical Center and four other institutions.

The researchers used a rat model to explore the effects of growth hormone and another compound, IGF-1 (insulin-like growth factor 1) on adult rats and found paradoxical effects, according to William E. Sonntag, Ph.D., professor of physiology and pharmacology at Wake Forest University Baptist Medical Center and the lead investigator.

"Things that happen when you are an adolescent may have an impact on how long you live and what you die of," he said.

"The presence of growth hormone and IGF-1 is necessary for maintenance of cognitive function and prevention of cartilage degeneration," Sonntag and his colleagues reported in an article in Endocrinology, published on-line today. But the hormones also increase cancer and other diseases that limit lifespan.

The researchers developed a strain of dwarf rats that were naturally deficient in both growth hormone and in IGF-1. To mimic the rise in growth hormone and IGF-1 during adolescence in normal rats, some of these deficient rats were given growth hormone while they were between 4 and 14 weeks of age ?rat adolescence. Then hormone treatment was stopped and the animals had lower growth hormone and IGF-1 levels the rest of their lives.

That had an effect on cancer: 88 percent of "normal" male rats have tumors at death. The male rats that had a lifelong deficiency of growth hormone had substantially fewer tumors ?63 percent ?and the percent of tumors that were fatal was reduced from 57 percent to 31 percent.

The same pattern occurred for kidney disease, which was found in 74 percent of the normal male animals at the time of their deaths. None of the growth-hormone deficient animals developed kidne
'"/>

Source:Wake Forest University Baptist Medical Center


Page: 1 2

Related biology news :

1. Iron Deficiency Sparks Dramatic Changes In Gene Expression
2. Plants, animals share molecular growth mechanisms
3. U-M scientists find genes that control growth of common skin cancer
4. Researchers discover chemical compounds that affect plant growth
5. Physical and functional interaction of key cell growth molecules linked to cancer
6. Hormones and growth: The control of body size and developmental growth rate in fruit flies
7. Researchers find molecule that inhibits regrowth of spinal nerve cells
8. Gradient guides nerve growth down spinal cord
9. Suppressing growth hormone in early adulthood may prevent cancer
10. Scientists discover genetic pathway responsible for breast cancer cell growth
11. Breath of the dragon: ERS-2 and Envisat reveal impact of economic growth on Chinas air quality
Post Your Comments:
(Date:5/17/2013)... An international team of scientists using a new ... inside a living frog embryo in greater detail than ... advance biological research and the search for new treatments ... Karlsruher Institut fr Technologie in Germany, in collaboration with ... Energy,s Argonne National Laboratory, released the most precise depiction ...
(Date:5/16/2013)... FASEB MARC (Maximizing Access to Research Careers) Program ... Endocrine Society (ENDO) 95th Annual Meeting in San ... are meant to promote the entry of students, ... mainstream of the basic science community and to ... ENDO 2013 Annual Meeting. , Awards are given ...
(Date:5/16/2013)... living closer to a fast food restaurant had a ... further away from fast food, according to researchers at ... this association was particularly strong among those with a ... in the American Journal of Public Health ... fast food restaurant, and among lower-income African-Americans, the density, ...
Breaking Biology News(10 mins):New X-ray method shows how frog embryos could help thwart disease 2Body mass index of low income African-Americans linked to proximity of fast food restaurants 2Body mass index of low income African-Americans linked to proximity of fast food restaurants 3
... species that live at high elevations? Are plant populations ... the valleys between them act as barriers, or can ... distant populations? Dr. Andrea Kramer and colleagues from ... at Chicago were interested in pursuing these questions, particularly ...
... environmental contaminants in a mother,s body decrease during breast-feeding. After ... environmental contaminants in breast milk drop by 15 94 ... Institute of Public Health. There has been little study into ... best food for infants and contains all the substances a ...
... (memsys) and Nanyang Technological University (NTU) are collaborating to ... contaminated with oil., If successful, the wider application of ... by companies here to produce distilled water for their ... located at Singapore,s Jurong Island, which produce a lot ...
Cached Biology News:Islands in the sky: How isolated are mountain top plant populations? 2Islands in the sky: How isolated are mountain top plant populations? 3Islands in the sky: How isolated are mountain top plant populations? 4New study of environmental contaminants in breast milk 2memsys-NTU partnership to enhance water desalination technology 2
(Date:5/17/2013)... Dr. Sparano is Professor of Medicine ... the Albert Einstein College of Medicine and Associate Chairman ... Center. He is also Associate Director for Clinical ... Einstein Breast Cancer Working Group, a multidisciplinary group of ... He also serves as Vice Chair of the National ...
(Date:5/17/2013)... The new Public-Private Partnership (PPP) in Photonics established ... annual meeting drew praise from community leaders from SPIE ... the action “a huge step forward … a lasting ... , The Board of Stakeholders voted to approve in ... its 29 April meeting in Brussels, which was sponsored ...
(Date:5/17/2013)... , May 17, 2013 /PRNewswire-iReach/ -- Aridis ... been reached with Switzerland -based ... anti-infective human monoclonal antibody (mAb) products, and technologies. ... mAb products for treatment of infections by common ... Staphylococcus aureus , Pseudomonas aeruginosa , ...
(Date:5/17/2013)... 17, 2013 Rust removal is one of ... home items could be damaged. To help rust contractors make ... its no-scrubbing rust remover it called Rusterizer. It ... with 10% discount. , My Cleaning Products explained that rust ... or by staining them. The first one, it said, ...
Breaking Biology Technology:Joseph A. Sparano, MD, Named Vice Chair of ECOG-ACRIN Cancer Research Group 2Joseph A. Sparano, MD, Named Vice Chair of ECOG-ACRIN Cancer Research Group 3SPIE Joins in Praise for ‘Huge Step Forward’ for Innovation R&D Enabled by Photonics21 Actions 2SPIE Joins in Praise for ‘Huge Step Forward’ for Innovation R&D Enabled by Photonics21 Actions 3Aridis Pharmaceuticals Announces Acquisition of Monoclonal Antibody Products and Technologies From Kenta Biotech 2Aridis Pharmaceuticals Announces Acquisition of Monoclonal Antibody Products and Technologies From Kenta Biotech 3Organic-Based Rust Remover Cuts Down Price by 10%, My Cleaning Products Details Mechanics How to Get the Discount 2
... May 23, 2012 Reportlinker.com announces ... is available in its catalogue: ... to 2018 - Novel Oral JAK ... Drugs (DMARD) Will Drive Continued Growth ...
... Oxford, May 22, 2012 - Researchers in Ireland have ... glasses to produce high-precision molds for making tiny plastic ... be used in the next generation of computer memory ... In their article published in the latest edition of ...
... 2012   GeneLink, Inc. (OTCBB: GNLK.OB, "the ... financial results for the three months ended March 31, 2012. ... February 10, 2012 the Company closed on the sale of ... transaction entered into in October 2011. The sale price was ...
Cached Biology Technology:Arthritis Therapeutics Market to 2018 - Novel Oral JAK Inhibitors and Biologic Disease Modifying Anti-Rheumatic Drugs (DMARD) Will Drive Continued Growth Across Key Indications 2Arthritis Therapeutics Market to 2018 - Novel Oral JAK Inhibitors and Biologic Disease Modifying Anti-Rheumatic Drugs (DMARD) Will Drive Continued Growth Across Key Indications 3Arthritis Therapeutics Market to 2018 - Novel Oral JAK Inhibitors and Biologic Disease Modifying Anti-Rheumatic Drugs (DMARD) Will Drive Continued Growth Across Key Indications 4Arthritis Therapeutics Market to 2018 - Novel Oral JAK Inhibitors and Biologic Disease Modifying Anti-Rheumatic Drugs (DMARD) Will Drive Continued Growth Across Key Indications 5Arthritis Therapeutics Market to 2018 - Novel Oral JAK Inhibitors and Biologic Disease Modifying Anti-Rheumatic Drugs (DMARD) Will Drive Continued Growth Across Key Indications 6Arthritis Therapeutics Market to 2018 - Novel Oral JAK Inhibitors and Biologic Disease Modifying Anti-Rheumatic Drugs (DMARD) Will Drive Continued Growth Across Key Indications 7Arthritis Therapeutics Market to 2018 - Novel Oral JAK Inhibitors and Biologic Disease Modifying Anti-Rheumatic Drugs (DMARD) Will Drive Continued Growth Across Key Indications 8Arthritis Therapeutics Market to 2018 - Novel Oral JAK Inhibitors and Biologic Disease Modifying Anti-Rheumatic Drugs (DMARD) Will Drive Continued Growth Across Key Indications 9Arthritis Therapeutics Market to 2018 - Novel Oral JAK Inhibitors and Biologic Disease Modifying Anti-Rheumatic Drugs (DMARD) Will Drive Continued Growth Across Key Indications 10Arthritis Therapeutics Market to 2018 - Novel Oral JAK Inhibitors and Biologic Disease Modifying Anti-Rheumatic Drugs (DMARD) Will Drive Continued Growth Across Key Indications 11Arthritis Therapeutics Market to 2018 - Novel Oral JAK Inhibitors and Biologic Disease Modifying Anti-Rheumatic Drugs (DMARD) Will Drive Continued Growth Across Key Indications 12Making microscopic machines using metallic glass 2GeneLink Reports First Quarter 2012 Financial Results 2
Alexa Fluor 647 anti-mouse Qa-2...
Mouse monoclonal [0.T.81] to Lac1 ( Abpromise for all tested applications). Antigen: Recombinant TrpE fusion protein containing full length E. coli Lac1....
Peptide-affinity Purified Polyclonal Antibody to ICEBERG Peptide with sequence EEDPQLASKMGLH, from C Terminus of the protein sequence according to NP_067546...
3T3 cells (RSV-transformed) Source: Cell Lysate Form: Ready to Use Application: Western Blotting Control...
Biology Products: