Navigation Links
Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems

Deficiencies of growth hormone and similar compounds may reduce cancer and kidney disease late in life, but also may lead to cartilage degeneration and impaired memory and learning ability, according to research at Wake Forest University Baptist Medical Center and four other institutions.

The researchers used a rat model to explore the effects of growth hormone and another compound, IGF-1 (insulin-like growth factor 1) on adult rats and found paradoxical effects, according to William E. Sonntag, Ph.D., professor of physiology and pharmacology at Wake Forest University Baptist Medical Center and the lead investigator.

"Things that happen when you are an adolescent may have an impact on how long you live and what you die of," he said.

"The presence of growth hormone and IGF-1 is necessary for maintenance of cognitive function and prevention of cartilage degeneration," Sonntag and his colleagues reported in an article in Endocrinology, published on-line today. But the hormones also increase cancer and other diseases that limit lifespan.

The researchers developed a strain of dwarf rats that were naturally deficient in both growth hormone and in IGF-1. To mimic the rise in growth hormone and IGF-1 during adolescence in normal rats, some of these deficient rats were given growth hormone while they were between 4 and 14 weeks of age ?rat adolescence. Then hormone treatment was stopped and the animals had lower growth hormone and IGF-1 levels the rest of their lives.

That had an effect on cancer: 88 percent of "normal" male rats have tumors at death. The male rats that had a lifelong deficiency of growth hormone had substantially fewer tumors ?63 percent ?and the percent of tumors that were fatal was reduced from 57 percent to 31 percent.

The same pattern occurred for kidney disease, which was found in 74 percent of the normal male animals at the time of their deaths. None of the growth-hormone deficient animals developed kidne y disease.

They found that animals with a deficiency in growth hormone initiated after adolescence had up to a 14.6 percent increase in lifespan. All animals in the study lived until they died of natural causes.

The researchers used several tests to measure memory and learning. They found that growth-hormone-deficient rats had impaired learning ability compared to normal animals of the same age. A similar pattern occurred in memory tests.

"The presence of growth hormone and IGF-1 are required for optimal performance on tests of learning and memory throughout life," they said. "Growth hormone/IGF-1 replacement in older animals reverses the age-related decline in cognitive function."

The group also found that "cartilage degeneration that normally accompanies aging is accelerated by the absence of growth hormone."

The researchers concluded that cancer risk as well as other age-related pathologies could be substantially decreased in these animals by inducing a modest deficiency of growth hormone and IGF-1 early in life. However, there is a tradeoff and deficiency of growth hormone and IGF-1 may impair learning and memory and accelerate some degenerative diseases.


'"/>

Source:Wake Forest University Baptist Medical Center


Related biology news :

1. Iron Deficiency Sparks Dramatic Changes In Gene Expression
2. Plants, animals share molecular growth mechanisms
3. U-M scientists find genes that control growth of common skin cancer
4. Researchers discover chemical compounds that affect plant growth
5. Physical and functional interaction of key cell growth molecules linked to cancer
6. Hormones and growth: The control of body size and developmental growth rate in fruit flies
7. Researchers find molecule that inhibits regrowth of spinal nerve cells
8. Gradient guides nerve growth down spinal cord
9. Suppressing growth hormone in early adulthood may prevent cancer
10. Scientists discover genetic pathway responsible for breast cancer cell growth
11. Breath of the dragon: ERS-2 and Envisat reveal impact of economic growth on Chinas air quality
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/25/2016)... --  Unisys Corporation (NYSE: UIS ) today announced the ... Airport, New York City , to help ... enter the United States using passports that ... testing of the system at Dulles last year. The system ... January 2016. --> pilot testing of the system ...
(Date:1/20/2016)... , Jan. 20, 2016 A market ... to directly benefit from the explosion in genomics knowledge. ... Howe Sound Research. A range of dynamic trends are ... - personalized medicine - pharmacogenomics - pathogen evolution ... with large markets - greater understanding of the role ...
(Date:1/13/2016)... --> --> ... report titled - Biometric Sensors Market - Global Industry Analysis, ... to the report, the global biometric sensors market was valued at ... US$1,625.8 mn by 2023, expanding at a CAGR of ... the biometric sensors market is expected to reach 1,799.6 ...
Breaking Biology News(10 mins):
(Date:2/5/2016)... 2016  In the pharmaceutical industry the medical affairs ... launch activities including the identification and engagement of key ... especially high in the oncology therapeutic area where most ... the Role of Medical Affairs in Oncology Launch Excellence ... therapies find better ways to utilize medical affairs to ...
(Date:2/5/2016)... -- Amarantus BioScience Holdings, Inc. ... products for Regenerative Medicine, Neurology and Orphan Diseases, announced ... from the US Food and Drug Administration (FDA) for ... granted orphan drug designation (ODD) by the US FDA ... Inc. (OTCQB: AMBS), a biotechnology company ...
(Date:2/4/2016)... Francisco, CA (PRWEB) , ... February 04, 2016 ... ... of enterprise talent development and compliance training, today announced an interactive FDA ... Morf Playbook™. The RAPS (Regulatory Affairs Professional Society) accredited interactive course on ...
(Date:2/4/2016)... 2016  Sangamo BioSciences, Inc. (NASDAQ: SGMO ), ... Edward Lanphier , Sangamo,s president and chief executive ... Sangamo,s ZFP Therapeutic ® development programs and an ... ET on Thursday, February 11, 2016, at the Leerink ... conference is being held in New York ...
Breaking Biology Technology: