Navigation Links
Defense peptide found in primates may block some human HIV transmissions

As primates evolved 7 million years ago, the more advanced species stopped making a protein that University of Central Florida researchers believe can effectively block the HIV-1 virus from entering and infecting blood cells.

HIV-1 often mutates quickly to overcome antiviral compounds designed to prevent infections. But a research team led by Associate Professor Alexander Cole of UCF's Burnett College of Biomedical Sciences has demonstrated that over 100 days the virus develops only weak resistance to retrocyclin, a defense peptide still found in monkeys and lower primates.

If additional laboratory tests demonstrate only weak resistance, Cole will study how retrocyclin could be developed into a drug designed to prevent the HIV virus from entering human cells.

Cole is also working with Henry Daniell, a UCF professor of molecular biology and microbiology, to develop a way to grow retrocyclin through genetically engineered tobacco plants. The retrocyclin gene would be incorporated into the chloroplast genome of tobacco cells before the plants grow. Daniell has developed a similar approach to growing anthrax vaccine in tobacco plants.

An inexpensive way to produce the drug with only a small amount of tobacco would help to make it accessible in areas such as Southeast Asia, Africa and the Caribbean where the disease spreads most quickly.

"If we could develop retrocyclin in plants and produce enough of the drug cheaply, we could potentially save a lot of lives," Cole said.

Cole was recently awarded about $4 million of National Institutes of Health grants through 2011 for the HIV-1 research and similar studies. The grants were provided through the National Institute of Allergy and Infectious Diseases; National Institute of Child Health and Human Development; and the National Heart, Lung and Blood Institute.

Cole started his research into theta-defensins at the University of California, Los Angeles, before he mov
'"/>

Source:University of Central Florida


Page: 1 2 3

Related biology news :

1. Defenseless plants arm themselves with metals
2. How A Latent Virus Eludes Immune Defenses
3. Product improves peptide identification for proteomics research
4. Discovery clarifies role of peptide in biological clock
5. Frog peptides block HIV in lab study
6. New peptide antibiotic isolated from American oyster
7. Scientists identify 36 genes, 100 neuropeptides in honey bee brains
8. Does a peptide affect the hearts response to social isolation?
9. Synthetic peptide targets latent papilloma virus infections
10. UCLA AIDS Institute researchers find a peptide that encourages HIV infection
11. New component of the brakes on nerve regeneration found
Post Your Comments:
(Date:12/5/2014)... , Dec. 4, 2014  Tute Genomics, a ... $2.3 million in Series A1 funding led by UK-based ... also participated in the investment round. "We ... healthcare community adopts next-generation sequencing and seeks new approaches ... Reid Robison , MD MBA, and CEO of ...
(Date:11/21/2014)... -- According to a new market research ... Access Control, Intrusion Detection, Parking Management, Under Vehicle Inspection), ... Geography - Global Forecasts to 2020", published by MarketsandMarkets, ... around $25 Billion in 2014 and is expected to ... of 8.69%. Browse 116 market data Tables ...
(Date:11/21/2014)... , Nov. 20, 2014   Atmel® Corporation ... in microcontroller (MCU) and touch technology solutions, today launched ... sensors with the widest V cc range ... temperature accuracy and faster I 2 C bus communication ... serial EEPROM memory making them ideal for consumer, industrial, ...
Breaking Biology News(10 mins):Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4
... 2011 Thanks to almost $1 million in new funding ... the University of Houston (UH) will soon be enhancing its ... applied toward the purchase and installation of an advanced imaging ... With access to the latest in imaging technology, researchers from ...
... Principal investigator Dacheng Ren, assistant professor in the ... Syracuse University,s L.C. Smith College of Engineering and ... Biomaterials Institute (SBI); and co-PIs professors Rebecca Bader ... R. "Suresh" Sureshkumar (BMCE) and Ramesh Raina (biology), ...
... Fuel made from wood could become a competitive commercial ... the wood biofuel industry is supported, according to a ... is currently blended with gasoline to satisfy government-mandated targets ... corn, wood-based biofuel is considered more sustainable but is ...
Cached Biology News:UH receives $990K grant to enhance cancer research facilities 2Syracuse University receives $2 million from NSF 2Syracuse University receives $2 million from NSF 3Wood biofuel could be a competitive industry by 2020: UBC study 2
(Date:12/19/2014)... , Dec. 19, 2014 Bina Technologies, Inc. ... announced today that they have been acquired by Roche ... is a privately held company that provides a big ... generation sequencing (NGS) data for the academic and translational ... Sequencing Unit, and will continue to focus on development ...
(Date:12/19/2014)... LayerBio is an MIT spin-off developing novel drug ... Eye Institute (NEI) at the National Institutes of Health ... to develop a drug-eluting intraocular lens (IOL) for cataract ... vision loss in people over age 40 and the ... Mandell, LayerBio’s Founder and CEO, "There is a critical ...
(Date:12/19/2014)... 2014 The empty capsules market ... ageing population and technological innovations in the empty ... are catalysing the growth of the empty capsules ... , Scope of Report , The report ... new entrants/smaller firms to gauge the pulse of ...
(Date:12/19/2014)... -- Relmada Therapeutics, Inc. (OTCQB: RLMD), a clinical-stage company ... announced the results of its annual general meeting of ... year in Relmada,s history and it set the stage ... Sergio Traversa , chief executive officer of Relmada. "Over ... human resource and clinical development objectives that position Relmada ...
Breaking Biology Technology:Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3LayerBio Awarded NIH Grant to Develop a Drug Delivery Device for Cataract Surgery 2Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 2Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 3Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 4Relmada Therapeutics Announces Results of Annual Shareholders Meeting 2
... Nov. 5, 2009 Complete Genomics, a third-generation ... report in the journal Science describing its ... from three complete human genomes. The consumables cost for ... nanoarrays ranged from $8,005 for 87x coverage to $1,726 ...
... , QUINCY, Mass., Nov. 6 Myriant Technologies ... of renewable bio-chemicals, Uhde Corporation of America ... of the world,s leading engineering contractors (jointly "Uhde"), ... construction (EPC) of Myriant,s biobased Succinic Acid plants ...
... Therapeutics, Inc. delivered two presentations today on its ITCA ... treatment of type 2 diabetes at the Ninth Annual ... http://www.newscom.com/cgi-bin/prnh/20050301/SFTU126LOGO ) , Continuous Subcutaneous Delivery ... and Reduces Weight in a 28-day Phase 1b Study ...
Cached Biology Technology:Complete Genomics publishes in Science on low-cost sequencing of 3 human genomes 2Myriant Technologies LLC, Uhde Corporation of America and Uhde GmbH Announce Alliance for Engineering, Procurement & Construction of World Scale Renewable Succinic Acid Plants 2Myriant Technologies LLC, Uhde Corporation of America and Uhde GmbH Announce Alliance for Engineering, Procurement & Construction of World Scale Renewable Succinic Acid Plants 3Intarcia Therapeutics, Inc. Presents Positive Results from Two Studies of ITCA 650 for the Treatment of Type 2 Diabetes at the Ninth Annual Diabetes Technology Meeting 2Intarcia Therapeutics, Inc. Presents Positive Results from Two Studies of ITCA 650 for the Treatment of Type 2 Diabetes at the Ninth Annual Diabetes Technology Meeting 3Intarcia Therapeutics, Inc. Presents Positive Results from Two Studies of ITCA 650 for the Treatment of Type 2 Diabetes at the Ninth Annual Diabetes Technology Meeting 4Intarcia Therapeutics, Inc. Presents Positive Results from Two Studies of ITCA 650 for the Treatment of Type 2 Diabetes at the Ninth Annual Diabetes Technology Meeting 5
...
... the Easy-Titer Human IgM Assay Kit to ... and easy-to-perform assay for Human IgM that ... kit incorporates a simple mix-and-read assay that ... from 15-500 ng/ml in approximately 30 minutes. ...
... aqueous solution that contains a purified bovine ... a saline solution, pH 6.5 7.5, ... and 0.02% bromonitrodioxane as a preservative. ... stabilizer for biologically active components in solution, ...
... adsorption and clarification reagent; Ideal for ... of antibodies, proteins, nucleic acids, & ... cross-reactivity, and improves downstream processing; Utilizes ... non-ionic adsorbent supplied as a suspension ...
Biology Products: