Navigation Links
Defective Gene Linked to Two Inherited Immune Deficiencies

cific role in orchestrating the immune response. Defects in TACI were found in 4 of 19 unrelated patients with CVID and in 1 of 16 unrelated patients with IgA deficiency. None of 50 healthy people they studied had a TACI mutation. The scientists believe that it is likely that as yet unidentified genetic defects underlie CVID and IgA deficiency in those cases where TACI was not mutated.

When the scientists further examined four of the five individuals with TACI mutations, they found all four had relatives with the same mutations. Eleven of the 12 identified relatives with CVID or IgA deficiency reported a history of recurrent infections and were also found to have low levels of IgA and/or low levels of another type of antibody, immunoglobulin G (IgG).

TACI mutations interfere with two aspects of the immune response that involve maturation of B cells. Normally, TACI triggers B cells to switch from making immunoglobulin M (IgM), an antibody produced early in the immune response, to making other antibodies such as IgA and IgG. More important, TACI signals B cells to produce antibodies against specific invading bacteria and viruses.

Because TACI mutations are genetically dominant, a person with TACI mutations in one of the two TACI genes he or she inherits is unable to mount a strong antibody response. Each child of a person so affected has a 50 percent chance of inheriting the mutation and being predisposed to IgA deficiency and CVID.

“A test for TACI defects would enable the diagnosis of more children and their relatives with these immune deficiencies,?says Dr. Geha, senior author of the study and the James Gamble Professor of Pediatrics at Harvard Medical School. “Many children who are sick with these disorders are now missed, because they can have normal IgA and IgG levels, yet they still have poor antibody responses and get the same bacterial and virus infections again and again.?/p>

But the gene discovery will not immediately cha
'"/>

Source:NIH


Page: 1 2 3

Related biology news :

1. Defective immune system response to smallpox vaccine detailed in new study
2. New SARS Protein Linked To Important Cell Doorway
3. Breast-Cancer Risk Linked to Exposure to Traffic Emissions at Menarche, First Birth
4. Use of Insecticides Linked to Lasting Neurological Problems for Farmers
5. Nighttime Dying Linked To Sleep Apnea From Brain Cell Loss
6. Gene Therapy Cures Inherited Liver Disease In Rats
7. New Therapeutic Target Identified In Inherited Brain Tumor Disorder
8. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
9. Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells
10. First North American Encapsulated Islet Transplant without Long-term Immune Suppression into a Patient with Type 1 Diabetes
11. Newly Discovered Branding Process Helps Immune System Cells Pick Their Fights
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Defective Gene Linked Two Inherited Immune Deficiencies

(Date:9/29/2014)... "human activities in this area of the world have contributed ... grown for use as a cooking oil and biofuel, while ... the most widely produced edible oil in the world, and ... soybean oil. , The environmental effects of such growth have ... crop, and the preferred method is fire. The clearing often ...
(Date:9/29/2014)... of Texas at Arlington research team says recently identified ... their lab could open doors for homeland security and ... in the Oct. 1 issue of Optics Letters ... co-authors describe a new method to fabricate transparent nanoscintillators ... until a transparent ceramic is formed. A scintillator ...
(Date:9/29/2014)... PULLMAN, Wash. Scientists at Washington State University ... specifically, Granny Smith apples may help prevent ... be the first to assess these compounds in ... in October,s print edition of the journal ... apples are a good source of these nondigestible ...
Breaking Biology News(10 mins):UT Arlington researchers develop new transparent nanoscintillators for radiation detection 2UT Arlington researchers develop new transparent nanoscintillators for radiation detection 3An apple a day could keep obesity away 2
... pressure were recently identified in a comprehensive international ... study, in which Uppsala University researchers participated, are ... Nature Genetics . High blood pressure ... Previous studies have shown that it is extremely ...
... May 8 Military and civilian personnel from the ... local homeland security, law enforcement and other first-responder personnel ... been encouraged to register and attend the 2009 Force ... held at Stafford Regional Airport and Marine Corps Base, ...
... and south sides of a house may decrease summertime ... a recent study* of California homes by researchers from ... the U.S. Department of Agriculture (USDA). The first ... the effects of shade on 460 single-family homes in ...
Cached Biology News:Comprehensive genetic study paves way for new blood-pressure medicines 2Demonstration Features Commercial Technology for Combating Terrorism 2New study: Home energy savings are made in the shade 2
(Date:9/29/2014)... food security, emerging diseases and biodiversity loss requires ... in Science Express that was co-authored ... College of Agriculture and Life Sciences. , For ... scientists has reviewed progress in addressing a broad ... management using approaches that consider evolutionary histories and ...
(Date:9/29/2014)... , Sept. 29, 2014 Research ... "Process Liquid Analyzer, Gas Analyzer, and Gas Chromatograph Market ... & Region - Global Trends & Forecast to 2013 ... A process analyzer is a process analytical instrument ... real-time. It has redefined the way by which companies ...
(Date:9/29/2014)... Transparency Market Research, in its report titled ‘Peptide ... Application - Cancer, Metabolic, CVS, CNS & others, by ... Global Industry Analysis, Size, Share, Growth, Trends and Forecast, ... market was worth US$14.1 billion in 2011 and is ... 8.7% CAGR. , The two main types of peptide ...
(Date:9/29/2014)... 29, 2014  Atlas Venture, an early stage venture ... innovation, today announced that Jason Rhodes , President ... EPZM ), is joining the firm,s life sciences investing ... At Atlas, Rhodes will work closely with the ... an accomplished record in company creation, deal making and ...
Breaking Biology Technology:Evolutionary biology: It's not just for textbooks anymore 2Evolutionary biology: It's not just for textbooks anymore 3Global Process Liquid Analyzer, Gas Analyzer, and Gas Chromatograph (PH/ORP, Chlorine, Oxygen, Carbon dioxide) Market - Trends & Forecast to 2020 2Global Process Liquid Analyzer, Gas Analyzer, and Gas Chromatograph (PH/ORP, Chlorine, Oxygen, Carbon dioxide) Market - Trends & Forecast to 2020 3Global Process Liquid Analyzer, Gas Analyzer, and Gas Chromatograph (PH/ORP, Chlorine, Oxygen, Carbon dioxide) Market - Trends & Forecast to 2020 4Global Peptide Therapeutics Market to be Worth US$25.4 Billion by 2018: Transparency Market Research 2Global Peptide Therapeutics Market to be Worth US$25.4 Billion by 2018: Transparency Market Research 3Atlas Venture Names Jason Rhodes, Veteran Investor and President and CFO of Epizyme, As Partner on Life Sciences Investing Team 2
... -- China YCT,International Group, Inc. (OTC Bulletin ... Shandong Yongchuntang Biology Technology,Co. Ltd. ("Shandong YCT"), ... China, has been awarded the honor of ... new pharmaceuticals sector. The,award was conferred by ...
... 10 Oxford Finance Corporation and GE,Healthcare Financial ... senior secured loan to Astex Therapeutics Limited. This ... a biotechnology company in,Europe., Astex Therapeutics, based ... biotech companies in the UK, concentrating on the ...
... Gastroenterology Panel Discussion, ISELIN, N.J., Dec. 10 ... Executive Officer Elkan R. Gamzu,Ph.D. will participate in a ... Conference taking place December 12,- 13, 2007 at the ... New York.,The panel is entitled "Going With Your Gut: ...
Cached Biology Technology:CYIG Awarded China's "Top 100 Enterprises" in New Pharmaceuticals, Selected as National "'Torch Plan' Key High-Tech Enterprise" 2Oxford Finance Corporation and GE Healthcare Financial Services Reaffirm Commitment to Biotech Sector in Europe 2Pharmos Corporation to Present at the 2007 RBC Capital Markets Healthcare Conference 2
... EZ-Spread Plating Beads Sterile plating in ... glass rods and potentially hazardous ethanol flaming, ... choices of ready-to-use sterile packaging: dispenser bottle for ... plating, Fastest and easiest way to ...
The new Silencer siRNA Starter Kit is perfect for researchers new to RNAi. It provides all of the reagents, protocols, and instructions necessary to get underway with siRNA transfection and ensure su...
... a regulated environment, Pipette Tracker Pro ... that automates gravimetric pipette calibration and ... meets todays regulatory compliance requirements. Pipette ... that includes a full security implementation, ...
... the yolk protein Vtg in plasma from juvenile ... biomarker for endocrine disrupting chemicals (EDCs) with estrogenic ... an accepted screening test for the estrogenic effects ... EIA kit is a double-antibody immunometric (sandwich) EIA ...
Biology Products: