Navigation Links
Defective Gene Linked to Two Inherited Immune Deficiencies

cific role in orchestrating the immune response. Defects in TACI were found in 4 of 19 unrelated patients with CVID and in 1 of 16 unrelated patients with IgA deficiency. None of 50 healthy people they studied had a TACI mutation. The scientists believe that it is likely that as yet unidentified genetic defects underlie CVID and IgA deficiency in those cases where TACI was not mutated.

When the scientists further examined four of the five individuals with TACI mutations, they found all four had relatives with the same mutations. Eleven of the 12 identified relatives with CVID or IgA deficiency reported a history of recurrent infections and were also found to have low levels of IgA and/or low levels of another type of antibody, immunoglobulin G (IgG).

TACI mutations interfere with two aspects of the immune response that involve maturation of B cells. Normally, TACI triggers B cells to switch from making immunoglobulin M (IgM), an antibody produced early in the immune response, to making other antibodies such as IgA and IgG. More important, TACI signals B cells to produce antibodies against specific invading bacteria and viruses.

Because TACI mutations are genetically dominant, a person with TACI mutations in one of the two TACI genes he or she inherits is unable to mount a strong antibody response. Each child of a person so affected has a 50 percent chance of inheriting the mutation and being predisposed to IgA deficiency and CVID.

“A test for TACI defects would enable the diagnosis of more children and their relatives with these immune deficiencies,?says Dr. Geha, senior author of the study and the James Gamble Professor of Pediatrics at Harvard Medical School. “Many children who are sick with these disorders are now missed, because they can have normal IgA and IgG levels, yet they still have poor antibody responses and get the same bacterial and virus infections again and again.?/p>

But the gene discovery will not immediately cha
'"/>

Source:NIH


Page: 1 2 3

Related biology news :

1. Defective immune system response to smallpox vaccine detailed in new study
2. New SARS Protein Linked To Important Cell Doorway
3. Breast-Cancer Risk Linked to Exposure to Traffic Emissions at Menarche, First Birth
4. Use of Insecticides Linked to Lasting Neurological Problems for Farmers
5. Nighttime Dying Linked To Sleep Apnea From Brain Cell Loss
6. Gene Therapy Cures Inherited Liver Disease In Rats
7. New Therapeutic Target Identified In Inherited Brain Tumor Disorder
8. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
9. Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells
10. First North American Encapsulated Islet Transplant without Long-term Immune Suppression into a Patient with Type 1 Diabetes
11. Newly Discovered Branding Process Helps Immune System Cells Pick Their Fights
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Defective Gene Linked Two Inherited Immune Deficiencies

(Date:6/18/2013)... Research Council, Laboratory of Molecular Biology, has been ... Young Investigator Award. Torrent is being recognized for ... algorithm to predict antimicrobial regions in proteins. Luis ... now applying this algorithm to interrogate full genomes ... with very appealing results." , Torrent obtained ...
(Date:6/18/2013)... for Molecular Pathology is proud to announce it will ... (FASEB) on July 1, 2013. The FASEB Board approved ... , The 26 constituent societies of FASEB represent more ... the advancement of research and education in biological and ... important now than ever," said Jennifer L. Hunt, MD, ...
(Date:6/18/2013)... DNA and this modification can occur in millions ... scientists believed that this epigenetic phenomenon actively reduced ... of researchers from the University of Geneva (UNIGE), ... the Faculty of Medicine, reveals that this is ... may play both a passive and active role ...
Breaking Biology News(10 mins):The American Society for Microbiology honors Marc Torrent 2The secret of DNA methylation 2
... NEW YORK, Dec. 14, 2010 Reportlinker.com announces that ... catalogue: Global Biochip Markets: Microarrays and ... INTRODUCTION  STUDY GOALS ... study was to determine the status of current and ...
... a severe illness called hemolytic-uremic syndrome (HUS) began in Germany ... people and sickened more than 2,000. The organism causing the ... coli O104:H4 that produces a Shiga toxin and causes ... O157:H7. Two isolates from this outbreak have been sequenced. Both ...
... June 6, 2011. Sustainability is the theme for the ... scheduled to meet in Portland June 19 to 21. ... from academia, government, non-profit groups, and private industry will ... industry and share information about innovations in the field., ...
Cached Biology News:Reportlinker Adds Global Biochip Markets: Microarrays and Lab-on-a-Chip 2Reportlinker Adds Global Biochip Markets: Microarrays and Lab-on-a-Chip 3Reportlinker Adds Global Biochip Markets: Microarrays and Lab-on-a-Chip 4Reportlinker Adds Global Biochip Markets: Microarrays and Lab-on-a-Chip 5Reportlinker Adds Global Biochip Markets: Microarrays and Lab-on-a-Chip 6Reportlinker Adds Global Biochip Markets: Microarrays and Lab-on-a-Chip 7Reportlinker Adds Global Biochip Markets: Microarrays and Lab-on-a-Chip 8Reportlinker Adds Global Biochip Markets: Microarrays and Lab-on-a-Chip 9Reportlinker Adds Global Biochip Markets: Microarrays and Lab-on-a-Chip 10Reportlinker Adds Global Biochip Markets: Microarrays and Lab-on-a-Chip 11Reportlinker Adds Global Biochip Markets: Microarrays and Lab-on-a-Chip 12Reportlinker Adds Global Biochip Markets: Microarrays and Lab-on-a-Chip 13Reportlinker Adds Global Biochip Markets: Microarrays and Lab-on-a-Chip 14Reportlinker Adds Global Biochip Markets: Microarrays and Lab-on-a-Chip 15Two isolates from E. coli outbreak available 2
(Date:6/19/2013)... NineSigma , Inc., of Cleveland , ... NineSights.com is now the innovation engine for the ... of innovators. From technology developers, to chemical ... out for its large community of innovators in an ... vetted by NineSigma. The community is free to join ...
(Date:6/19/2013)... 2013 Today DuPont Executive Vice President ... become leaders in the greatest challenge facing our time ... 2050. Borel spoke at the International Food ... about urgent need for students to contribute their time ... sustainable and reached in collaboration with others. , “Food ...
(Date:6/19/2013)... , June 19, 2013 ... Book Bureau presents Innovative Drug ... Formulation Technology Licensing Opportunities for ... ) There are ... controlled release drugs approved all ...
(Date:6/19/2013)... India’s vast and growing population ... worth up to a billion dollars per year ... is taking serious action to better regulate and ... presentation will examine:, ,     Recent changes ... and long term impacts ,     Foreseeable opportunities ...
Breaking Biology Technology:NineSigma Evolves Global Open Innovation through Social Media Platform, NineSights 2NineSigma Evolves Global Open Innovation through Social Media Platform, NineSights 3DuPont Leader Calls for New Generation of Food Visionaries to Fight Hunger 2Innovative Drug Delivery Systems: Novel Product and Formulation Technology Licensing Opportunities for Generic Pharmaceutical Companies 2Innovative Drug Delivery Systems: Novel Product and Formulation Technology Licensing Opportunities for Generic Pharmaceutical Companies 3
... Executive Chairman and CFO Assume Leadership Responsibilities; CEO Search ... ... Calif., Jan. 30 Genelabs,Technologies, Inc. (Nasdaq: GNLB ) announced ... Officer and Director of the,company, effective January 29, 2008. Irene A. ...
... BioPharma Corp. (TSX: HBP / Frankfurt: WKN 918864), ... BioPharma Corp.,announces that at the Company,s Annual General ... of the resolutions presented by,management, appointing KPMG LLP ... Jack Kay, Slawomir Majewski, and Gordon Lickrish as,directors, ...
... Fla., Jan. 30 John Wagner, M.D., recognized as,a ... transplantation, has joined,the team at CORD:USE Cord Blood Bank. ... stem cell biology will provide a,significant contribution to CORD:USE., ... a member of our,distinguished team," says Edward Guindi, M.D., ...
Cached Biology Technology:Genelabs Technologies, Inc. Announces Resignation of President and CEO 2Helix BioPharma shareholders vote in favour of management 2CORD:USE Cord Blood Bank Announces the Addition of Dr. John Wagner, a Pioneer in the Use of Umbilical Cord Blood Stem Cells, to Its Scientific Advisory Board 2CORD:USE Cord Blood Bank Announces the Addition of Dr. John Wagner, a Pioneer in the Use of Umbilical Cord Blood Stem Cells, to Its Scientific Advisory Board 3
... Introduction of a protein into cells ... cell signaling pathways, apoptotic pathways, and transcription ... for studying the effects of a specific ... transfect the protein directly into the cell. ...
Reacti-Bind DNA Coating Solution...
Immunogen GST fusion protein corresponding to full-length rat JNK3/ SAPK1b. Quality Assurance Routinely evaluated by immunoblot. Stability 2 years at -20°C from date of shipment GenBank A...
... The ProteoExtract™ Protein Precipitation Kit ... up of proteins from aqueous samples. ... by the presence of non-protein impurities ... in the protein sample that interfere ...
Biology Products: