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Decoy pill saves brain cells

ecoy, developed by Xu, reversed the outcomes. By tricking calpain, it prevented damage to the receptor and allowed the beneficial reaction to continue. In addition, it interrupted the feedback loop that stoked calpain activation.

"This is potentially a treatment for any conditions that involve this kind of excitotoxicity," Baudry said, and especially, he added, for the "window of opportunity" in the few hours after a stroke.

While a stroke kills some brain cells right away, others take much longer to die. If the stroke triggered a calcium-calpain feedback loop, treatment with decoy peptides might save some cells, Baudry said.

His group plans to test the treatment in a stroke model in mice.
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Source:University of Southern California


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