Navigation Links
Deconstructing brain wiring, one neuron at a time

Researchers have long said they won't be able to understand the brain until they can put together a "wiring diagram" ?a map of how billions of neurons are interconnected. Now, researchers at the Salk Institute for Biological Studies have jumped what many believe to be a major hurdle to preparing that chart: identifying all of the connections to a single neuron.

In the March 1 issue of the journal Neuron, the researchers describe how they modified the deadly rabies virus, turning it into a tool that can cross the synaptic space of a targeted nerve cell just once to identify all the neurons to which it is directly connected.

"We've wanted to do this for a very long time and finally found a way to make it possible," says the study's senior author, Edward M. Callaway, Ph.D., a professor in the Systems Neurobiology Laboratories. "It will offer us an unprecedented view of the brain."

The problem neuroscientists are confronted with "is akin to a computer user who tries to figure out how the machine's electronic chip works by looking down at it; there is no way to figure out how things are connected," Callaway says. "If you were given a wiring diagram, you could begin to understand how the chip moves electricity and how that operates the computer."

Neuroscientists also want to deconstruct the flow of electrical signals in the extraordinarily complex architecture of the brain and then correlate these neural circuits with such brain functions as perception and behavior. But these circuits are difficult to unravel because dozens of different neuronal types are entangled within a precisely connected network, and even neighboring neurons of the same type differ in connectivity and function.

So, researchers have been trying to figure out the pattern of connections typical of a type of neuron, to see which other cell types they connect with and how those connections are configured. To do this, they need a tracer that can tease apar
'"/>

Source:Salk Institute


Page: 1 2 3

Related biology news :

1. Controversial drug shown to act on brain protein to cut alcohol use
2. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
3. Mouse brain tumors mimic those in human genetic disorder
4. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
5. First atlas of key brain genes could speed research on cancer, neurological diseases
6. NYU study reveals how brains immune system fights viral encephalitis
7. Stem cells from brain transformed to produce insulin at Stanford
8. Birds brains reveal source of songs
9. Loves all in the brain: fMRI study shows strong, lateralized reward, not sex, drive
10. Revolutionary nanotechnology illuminates brain cells at work
11. A puzzle piece found in unraveling the wiring of the brain
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Deconstructing brain wiring one neuron time

(Date:7/27/2014)... might have survived the asteroid strike that wiped them ... later in history, scientists say. , A fresh study ... helped palaeontologists to build a new narrative of the ... They found that in the few million years before ... was experiencing environmental upheaval. This included extensive volcanic activity, ...
(Date:7/27/2014)... have shown the potential for global climate change to ... most part, ignored the interactions between increasing temperature and ... to damage crops. , A new study involving researchers ... significant, suggesting that policymakers need to take both warming ... , The study looked in detail at global production ...
(Date:7/25/2014)... first broad-scale estimate of air pollution removal by trees ... trees are saving more than 850 human lives a ... , While trees, pollution removal equated to an average ... impacts of that improvement are substantial. Researchers valued the ... nearly $7 billion every year in a study published ...
Breaking Biology News(10 mins):Dinosaurs fell victim to perfect storm of events, study shows 2Study: Climate change and air pollution will combine to curb food supplies 2Study: Climate change and air pollution will combine to curb food supplies 3First national study finds trees saving lives, reducing respiratory problems 2
... The behavior of marine larvae is central to fully understanding ... organisms. For the first time, a numerical study conducted by ... skills into realistic 3D flow fields, creating a powerful tool ... their way back to the reef after being out on ...
... & Science division of Thomson Reuters, the world,s ... professionals, today announced the launch of its ... a new initiative aimed at enabling access to ... developed with third-party partners. Through the ...
... Africa could benefit from access to treatment for an endemic ... of infection. Researchers tested hundreds of children aged between ... fever also known as bilharzia or schistosomiasis is ... they are perceived to be at low risk of exposure ...
Cached Biology News:Fish larvae find the reef by orienting: The earlier the better 2Fish larvae find the reef by orienting: The earlier the better 3Thomson Reuters Launches Life Sciences Partner Ecosystem to Drive Collaborative R&D Drug Processes 2Treatment to benefit African infants at risk of endemic fever 2
(Date:7/28/2014)... According to a new market ... Medicine (Bone and Joint) Market (By Technology - ... Applications - Bone Graft Substitutes, Osteoarticular Diseases, Allogeneic ... Analysis, Size, Share, Growth, Trends and Forecast, 2013 ... joint) market was valued at USD 2.6 billion ...
(Date:7/28/2014)... 28, 2014 According ... Market by Products (Consumables, Instruments, Services), Methods (Phenotypic, Genotypic), Applications (Pharmaceutical, ... (Detection, Characterization) - Global Forecasts to 2019" ... is estimated at $896.5 Million in 2014 ... by 2019, growing at a CAGR of ...
(Date:7/28/2014)... Appistry, Inc. , a leading ... power of genomics to next-generation medicine, announced today its ... . , Two Appistry staff will be joined ... for Genome Resources, and Mr. Neil Miller, director of ... City. Rounding out the panel are Appistry’s Dr. Richard ...
(Date:7/28/2014)... , July 28, 2014   The Atlas ... 4-star boutique hotel in the heart of The Atlas Town Center ... Photo - http://photos.prnewswire.com/prnh/20140725/130455 Photo - ... ATLAS , The Atlas ... suites, a sleek restaurant and bar, a wellness spa, a grand ...
Breaking Biology Technology:Regenerative Medicine Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 2Regenerative Medicine Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 3Regenerative Medicine Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 4Microbial Identification Market worth $1,194.1 Million by 2019 2Microbial Identification Market worth $1,194.1 Million by 2019 3Appistry Names Industry Experts from the National Center for Genome Resources and Mercy Children's, Kansas City, to Judge Pipeline Challenge Competition 2Texas' Biocorridor Announces the Atlas Hotel, Centerpiece of Mixed Use Community for Biotech Industry 2Texas' Biocorridor Announces the Atlas Hotel, Centerpiece of Mixed Use Community for Biotech Industry 3Texas' Biocorridor Announces the Atlas Hotel, Centerpiece of Mixed Use Community for Biotech Industry 4
... Idenix,Pharmaceuticals, Inc. (Nasdaq: IDIX ), a biopharmaceutical ... the treatment of human viral,and other infectious diseases, announced ... the 43rd Annual Meeting of the European,Association for the ... Milan, Italy,April 23 - 27, 2008. Full abstracts can ...
... Guaranteed Purchase Minimums - Carrington Provides Product Development, Manufacturing ... ... Distribution, IRVING, Texas, Feb. 25 Carrington,Laboratories, Inc. ... agreement with Universal Harvest Corporation of Nevada. Under the,terms of ...
... N.J., Feb. 25 Barr Pharmaceuticals,Inc. (NYSE: ... subsidiary, Duramed,Pharmaceuticals, Inc., has received notification that ... accepted for review its New Drug Application,(NDA) ... mg and ethinyl estradiol tablets 0.01 mg) ...
Cached Biology Technology:Idenix Announces Data Presentations at the 43rd Annual Meeting of the European Association for the Study of the Liver (EASL) 2Idenix Announces Data Presentations at the 43rd Annual Meeting of the European Association for the Study of the Liver (EASL) 3Carrington and Universal Harvest Sign Supply Agreement 2Duramed's Lo SEASONIQUE(R) NDA Accepted for Filing by FDA 2Duramed's Lo SEASONIQUE(R) NDA Accepted for Filing by FDA 3Duramed's Lo SEASONIQUE(R) NDA Accepted for Filing by FDA 4
DNA fragmentation factor & Inhibitor of CAD...
Anti-MT3-MMP Membrane-Type Metalloproteinase-3; propeptide domain; rabbit host...
Anti-CoralHue Dronpa Green Monoclonal Antibody Research Focus: cell surface antigens Storage: -20C Shipping Temperature: +4C...
Chlamydia pneumoniae (TWAR)...
Biology Products: