Navigation Links
Decoding protein structures helps illuminate cause of diabetes

Any photographer can vouch for the difficulty of capturing a clear picture of a moving target.

When it comes to molecules, however, sometimes the motion is exactly what scientists want to see - for example, to understand the pathological protein mis-folding and assembly that seem to underlie a host of human disorders, including diabetes and Alzheimer's disease.

Now, chemists at the University of Wisconsin-Madison have designed a powerful analytical tool capable of measuring molecular structures quickly and accurately enough to catch moving proteins in mid-fold and see the shapes of intermediate steps. As described in this week's online issue of the Proceedings of the National Academy of Sciences, the first applications of the technique offer a glimpse into the contorted form of a human protein that is implicated in type II diabetes.

Pancreatic damage in type II diabetes has been linked to toxic clumps of the protein hIAPP (human islet amyloid polypeptide), which is normally produced by the same cells that make insulin. An unknown trigger prompts the protein to fold into sharp fibers that poke holes in pancreatic cells, killing them.

Though scientists already have a good idea of the healthy "before" and dangerous "after" hIAPP structures, the steps in between remain somewhat of a mystery and may hold clues to what drives the transition, says UW-Madison chemistry professor Martin Zanni, who led the new study.

In trying to understand diabetes, "people have been looking at the fibers, but they should be looking at their formation," he says. "Somehow that mechanism is causing holes [in pancreas cells], which cause disease."

To break down this dynamic process, he adds, "We need tools that not only allow us to probe the molecular structures, but also look at how the structures change in time." Zanni's research group uses a method, known as two-dimensional infrared spectroscopy (2-D IR for short), that takes
'"/>

Source:University of Wisconsin-Madison


Page: 1 2

Related biology news :

1. Decoding the logic of olfaction
2. New, automated tool successfully classifies and relates proteins in unprecedented way
3. New binding target for oncogenic viral protein
4. Controversial drug shown to act on brain protein to cut alcohol use
5. Timing is everything: First step in protein building revealed
6. UWs Rosetta software to unlock secrets of many human proteins
7. Researchers find how protein allows insects to detect and respond to pheromones
8. Signaling protein builds bigger, better bones in mice
9. Ancient olfaction protein is shared by many bugs, offering new pest control target
10. Automatic extraction of gene/protein biological functions from biomedical text
11. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Decoding protein structures helps illuminate cause diabetes

(Date:7/30/2014)... Press (OUP) is pleased to announce its new relationship ... 2015, OUP and CINP will partner to publish ... a fully open-access journal. , Alan Frazer, Editor-in-Chief of ... size and expertise of OUP will further facilitate the ... of the very leading journals within neuropsychopharmacology. The conversion ...
(Date:7/30/2014)... of $1 million from the Cornelia Cogswell Rossi Foundation ... Center. , The newly established Connie Cogswell ... develop a greater breadth and depth of knowledge of ... pace of research to improve human health. , The ... the Laboratory and its external partners, supporting research to ...
(Date:7/30/2014)... from HIV infection could be as simple as inserting ... , University of Washington bioengineers have discovered a potentially ... women from contracting HIV. Their method spins the drug ... with moisture, releasing higher doses of the drug than ... creams. , "This could offer women a potentially more ...
Breaking Biology News(10 mins):OUP to partner with the International College of Neuropsychopharmacology 2Rossi Foundation pledges $1M for JAX neurobehavioral research center 2Dissolvable fabric loaded with medicine might offer faster protection against HIV 2Dissolvable fabric loaded with medicine might offer faster protection against HIV 3
... not always show it, but people are rarely born with ... and legs to grow in the right places and point ... between our fingers and toes and every other formative detail ... to construct and position our limbs were being perfected more ...
... one strain of an infectious disease can exist at ... in the August issue of The American Naturalist, Ken ... mathematical model to help explain multiple strains, showing that ... that the coexistence of multiple infectious disease strains result ...
... could peer microscopically into the closest freshwater pond, you'd ... you'd probably notice an oddly furry, pear-shaped organism gliding ... This tiny predator has a big name-- Tetrahymena thermophila ... star organism for research into how cells work. , ...
Cached Biology News:UF scientists discover evolutionary origin of fins, limbs 2UF scientists discover evolutionary origin of fins, limbs 3What's shaped like a pear and has 2 genomes? Check the pond 2What's shaped like a pear and has 2 genomes? Check the pond 3
(Date:7/31/2014)... SoundConnect , an award winning ... to announce the addition of Adobe Connects Learning ... tools to quickly deploy and manage online courses ... for desktop and mobile learning solutions. , Adobe ... online training solution, enabling organizations to deploy, measure, ...
(Date:7/30/2014)... and PARIS , July 30, 2014 ... SAN and NYSE: SNY) today announced that the Companies ... (FDA) rare pediatric disease priority review voucher in connection ...  The priority review voucher entitles the holder to designate ... expedited 6-month review from the filing date instead of ...
(Date:7/30/2014)... 2014  Replikins Ltd. today released new data on ... Before the current outbreaks, the mean Ebola Reston gene ... between 1995 and 2002 was 1.1; the mean Replikin ... sixteen-fold in 2013, thus predicting the current outbreaks in ... been shown to be able to predict outbreaks (1). ...
(Date:7/30/2014)... 30, 2014 With the accelerated ... personal health expenditure as well as the improved ... China diagnostic reagent industry has been developing quickly, ... In 2013, Chinese in vitro diagnostics market size ... from in vitro diagnostic reagents. , Read ...
Breaking Biology Technology:SoundConnect Enhances Portfolio with Adobe Connect Learning Management System (LMS) 2Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 2Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 3Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 4Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 5Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 6China Diagnostic Reagent Industry Report, 2013-2016 | Researchmoz 2China Diagnostic Reagent Industry Report, 2013-2016 | Researchmoz 3
... call for making available more detailed maps of the locations ... crops on a county and township level will give researchers ... wildlife, water quality, and on pest and beneficial insects. ... been planted with biotech crops in the U.S.," said Michelle ...
... Corporation, an advanced,biomaterials company, announced today that ... AlloSource., (Logo: http://www.newscom.com/cgi-bin/prnh/20080424/NETH117LOGO ), ... Bone Matrix (DBM),powder to be mixed with ... form EquivaBone(TM)., This agreement is consistent ...
... 24 Idenix,Pharmaceuticals, Inc. (Nasdaq: IDIX ) ... overview at the upcoming Morgan Stanley Global,Healthcare Unplugged ... p.m.,ET at The Ritz Carlton in Key Biscayne, ... the company presentation can be,accessed under "Calendar of ...
Cached Biology Technology:Scientists call for more access to biotech crop data 2ETEX Announces Supply Agreement with AlloSource 2
Porcine parvovirus and mycoplasma tested. Contains 0.5 g/L of trypsin (1:250) and 0.2 g/L of EDTA4Na in Hanks' Balanced Salt Solution without CaCl2 MgCl2 6H2O and MgSO4 7H2O. Contains phenol red....
... The pPIC9K and pPIC3.5K vectors carry ... to Geneticin Reagent in Pichia. Spontaneous generation ... by resistance to increased levels of Geneticin ... medium and screened for their level of ...
...
... Kit provides an extremely fast and ... intact protein complexes. Unlike other systems ... purification steps, this system takes advantage ... Column for fast protein purification under ...
Biology Products: