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Decisions, decisions: Male or female?

by germ cells as to whether to eventually develop into eggs or sperm," Wawersik said.

Though the team's observations were limited to the pathway's role in fruit fly germ cell communication, Van Doren said the same conduit also is active in humans and mice. When communication via the JAK/STAT pathway misfires, diseases such as cancer can result, he said.

"Evolutionarily, germ cells are one of the most ancient cell types, needed by every type of animal to reproduce," Van Doren said. "Their developmental program is very similar, whether we are talking fruit flies or humans. As a result, these findings could eventually help us understand and treat defects in germ cell development that lead to human infertility and disease."


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Source:Johns Hopkins University


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