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Data published in PNAS show antibodies can be made 10 times more toxic to cancer cells

many more antibodies can be used in the treatment of cancer than ever before."

Xencor's Fc variants were engineered using the company's XmAbTM technology, which couples computational design algorithms with high-throughput screening to rationally design the antibody constant region. The Fc portion of the constant region of the antibody has been shown in previous studies to be responsible for mediating antibody-dependent cell-mediated cytotoxicity and has been the target of Xencor's XmAb technology. Xencor has leveraged its XmAb technology to develop therapeutic antibodies, for which it plans to begin clinical testing next year.

"We've already applied the XmAb technology used in this research to generate a suite of patented Fc antibody variants that have optimized antibody-Fc receptor affinity, which translate into increased effector functions and improved cell cytotoxicity. These can be used to enhance the potency of nearly any antibody under development today," Dahiyat added.


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Source:Porter Novelli, Life Sciences


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