Navigation Links
Dartmouth study finds that arsenic inhibits DNA repair

Dartmouth researchers, working with scientists at the University of Arizona and at the Department of Natural Resources in Sonora, Mexico, have published a study on the impact of arsenic exposure on DNA damage. They have determined that arsenic in drinking water is associated with a decrease in the body's ability to repair its DNA.

"This work supports the idea that arsenic in drinking water can promote the carcinogenic effects of other chemicals," says Angeline Andrew, the lead author and a research assistant professor of community and family medicine at Dartmouth Medical School. "This is evidence that it's more important than ever to keep arsenic out of drinking water."

The study, which was published online on May 10, 2006, in the journal Environmental Health Perspectives, examined the drinking water and measured the arsenic levels in samples of urine and toenails of people who were enrolled in epidemiologic studies in New Hampshire, and in Sonora, Mexico.

Andrew and her colleagues examined the data in conjunction with tissue samples from the study participants to determine the effect of arsenic on DNA repair. To further corroborate their findings, the researchers conducted laboratory studies to examine the effects of arsenic on DNA repair in cultured human cell models.

"The DNA repair machinery normally protects us from DNA-damaging agents, such as those found in cigarette smoke," says Andrew. "The concern is that exposure to drinking water arsenic may exacerbate the harmful effects of smoking or other exposures."

Andrew explains that in regions of the United States where the rock contains higher levels of arsenic, the greater the likelihood that drinking water sources contain some potential adverse levels of the toxin. While the levels of arsenic in municipal water systems are regularly monitored, there is no mandated testing of arsenic levels in private wells. This is of particular concern since the regions where arsenic levels are high are in rural regions, such as New Hampshire, Maine, Michigan and some regions of the Southwest and Rockies. Private wells are common in these areas as primary sources of drinking water.


'"/>

Source:Dartmouth College


Related biology news :

1. GlycoFi and Dartmouth report full humanization of yeast glycosylation pathway in Science
2. Bioartificial kidney under study at MCG
3. W.M. Keck Foundation funds study of friendly microbes
4. Yellowstone microbes fueled by hydrogen, according to U. of Colorado study
5. Genome-wide mouse study yields link to human leukemia
6. Clam embryo study shows pollutant mixture adversely affects nerve cell development
7. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
8. Same mutation aided evolution in many fish species, Stanford study finds
9. Sequencing of marine bacterium will help study of cell communication
10. Genetically modified rice in China benefits farmers health, study finds
11. A new study examines how shared pathogens affect host populations
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/26/2017)... 2017  Securus Technologies, a leading provider of ... safety, investigation, corrections and monitoring, announces the appointment ... "Too often, too many offenders return to ... are trying to tackle this ongoing problem and ... family members. While significant steps are underway, Securus continues ...
(Date:2/21/2017)... , February 21, 2017 ... 70 Millionen US-Dollar wachsen. Nach einem Gespräch mit mehr als ... einige Hindernisse zu überwinden gilt, um diese Prognose zu ... ... anderem die Mobilisierung der finanziellen Mittel für die Biobank, ...
(Date:2/13/2017)... -- Former 9/11 Commission border counsel and Special Counsel ... of Identity Strategy Partners, LLP, today releases the ... Order: Protecting the Nation From Foreign Terrorist Entry Into ... President Trump,s ,Travel Ban, Executive Order gains more notoriety ... travel ban, it is important that our national discourse ...
Breaking Biology News(10 mins):
(Date:3/28/2017)... ... March 28, 2017 , ... Benchworks ... 22 in Philadelphia. The event was offered by the Chamber of Commerce for ... featured breakout groups and interaction with speakers who are leaders in their industries. ...
(Date:3/28/2017)... 28, 2017 Volition America, Inc., a wholly-owned U.S. ... engagement of Deborah Vollmer Dahlke , DrPH, CEO and ... Vollmer Dahlke,s role will be to assist the ... State of Texas and elsewhere in ... has significant experience over the past six years, helping ...
(Date:3/28/2017)... ... March 28, 2017 , ... ... initial release of LabKey’s newest software solution, LabKey Biologics . Built in ... pharma and biotech organizations, LabKey Biologics provides drug research teams tools for biological ...
(Date:3/28/2017)... ... March 28, 2017 , ... T3D Therapeutics, ... new orally administered treatment for Alzheimer’s disease (AD), today announced that Dr. Kathleen ... we seek to uniquely treat the metabolic dysfunctions inherent in Alzheimer’s disease and ...
Breaking Biology Technology: