( so it can trigger a critical series of ...)DNA repair proteins monitored at double-strand break

so it can trigger a critical series of signals linked to DNA repair. Inactive ATM exists as a pair of these molecules linked together. Kastan previously reported in the journal Nature how the inactive ATM molecules separate from each other in response to a double-strand break (http://www.stjude.org/media/0,2561,453_5484_3126,00.html).

To control when and where the double-strand breaks occurred during the study, the researchers used an enzyme called I-PpoI, which naturally seeks certain DNA areas to cut. The investigators modified I-PpoI so that they could better control when the enzyme moves into the nucleus and cleaves the DNA. The team then used a biochemical technique called chromatin immunoprecipitation to collect and identify repair proteins and show where each one bound to the DNA.
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Source:St. Jude Children's Research Hospital

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