Navigation Links
DNA repair proteins monitored at double-strand break

Investigators at St. Jude Children's Research Hospital had a molecule’s eye view of the human cell’s DNA repair kit as it assembled on a double-strand break to link together the broken ends. Double-strand breaks are ruptures that cut completely across the twisted, ladder-like structure of DNA, breaking it into two pieces.

Using a technique developed specifically for this project, the St. Jude researchers could determine when repair proteins arrived at or around the DNA break and evaluate its repair—even when particular proteins shifted away from the break to make room for others. A report on this work appears in the May 7 online issue of "Nature Cell Biology."

The findings are important because disruption of the precise movement of these repair proteins can cause mutations, cell death or cancer, and the ability to track the process so closely will give researchers critical insights into what can go wrong with DNA repair. This could lead to novel ways to make cancer cells more sensitive to therapy by blocking their ability to repair double-stranded breaks caused by chemotherapy or radiation. It could also suggest new strategies for enhancing repair of double-stranded DNA caused by radiation, natural oxidants in food or the body and other toxins that can cause disease and aging.

"Prior to this work, there was no practical and efficient way to find and study the DNA repair proteins that organize themselves on and around a double-strand break in human cells," said Michael Kastan, M.D., Ph.D., St. Jude Cancer Center director. "Our approach solved that problem and allowed us to document the cell’s response to double-strand DNA breaks over time. The technique provides significantly more information about the proteins that repair DNA than is possible using the standard microscope-based approach previously used for such work." Kastan is the paper’s senior author.

A deficiency in two of these repair proteins, ATM and NBS1, leads to def
'"/>

Source:St. Jude Children's Research Hospital


Page: 1 2 3

Related biology news :

1. Heart repair gets new muscle
2. Nano-bumps could help repair clogged blood vessels
3. New understanding of DNA repair may pave way to cancer treatments
4. Researchers pioneer new gene therapy technique using natural repair process
5. Circulating stem cells play small role in lung repair
6. Muscle repair: Making a good system better, faster; implications for aging, disease
7. Stressed cells spark DNA repair missteps and speed evolution
8. Scientists get first glimpse at how plants, most animals repair UV-damaged DNA
9. OHSU researchers discover potential mechanism to repair brain damage linked to Multiple Sclerosis
10. Discovering the first steps in transcription-coupled repair
11. Stem cell mobilization therapy appears to be ineffective in repairing damage caused by heart attack
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: DNA repair proteins monitored double strand break

(Date:4/17/2014)... Kessler Foundation has been named awardee of a ... of Defense Spinal Cord Injury Research Program. Gail ... randomized, double-blinded, controlled, multi-site clinical trial, which will ... after spinal cord injury. Dr. Forrest is assistant ... Kessler Foundation. Two additional sites will participate - ...
(Date:4/17/2014)... in about one per eight hundred births, Down syndrome ... genetic cause of intellectual disability. It results from a ... third copy of chromosome 21 (1% of the human ... team in the Department of Genetic Medicine and Development ... published in Nature , shed light on how ...
(Date:4/17/2014)... about eight years ago, Katia Silvera , a postdoctoral ... were on a field trip in a mountainous area in ... never seen before. , Unable to identify it, they contacted ... turned out to be an unnamed species. So Carnevali recently ... "Lophiaris" is the genus name, comprising about 40 species in ...
Breaking Biology News(10 mins):Kessler Foundation awarded Department of Defense grant for spinal cord injury research 2Trisomy 21: How an extra little chromosome throws the entire genome off balance 2Trisomy 21: How an extra little chromosome throws the entire genome off balance 3Orchid named after UC Riverside researcher 2Orchid named after UC Riverside researcher 3
... Angeles, London, New Delhi, Singapore and Washington DC (16 September, ... Journal of Dental Biomechanics (JDB), the second open access ... and the Hindawi Publishing Corporation. The Journal of ... to the study of biomechanics as it relates to dentistry. ...
... More than 125 years ago Charles Darwin first reported ... not the day and this week, scientists are reporting ... These rhythmic growth spurts, and the ability of plants to ... involved in circadian rhythms the "biological clock" genes that ...
... he discovered a gene that controls innate fear in ... the same gene promotes "helicopter mom" behavior in mice. ... female animals to protect newborn pups and interact cautiously ... concentrated in the amygdala, a key region of the ...
Cached Biology News:SAGE-Hindawi launch Journal of Dental Biomechanics 2'Biological clock' genes control plant growth 2No helicopter moms among Rutgers mutant mice 2No helicopter moms among Rutgers mutant mice 3
(Date:1/15/2014)... 2014 The Microcompetition with Foreign DNA theory ... of these latent viruses is the Epstein Barr Virus (EBV), ... arthritis (RA) is a chronic inflammatory disease that destroys the ... that RA patients have high concentrations of EBV DNA in ...
(Date:1/15/2014)... TAIPEI , Jan. 15, 2014 TaiGen Biotechnology ... an exclusive agreement with R-Pharm, a leading Russian pharmaceutical ... in the Russian Federation , ... Commonwealth Independent States (CIS). Nemonoxacin is a novel antibiotic for ...
(Date:1/14/2014)... Calif. , Jan. 14, 2014 As pet owners drew ... doubt many of them wrote: "Take better care of my furry ... even designer clothes and top-brand carrying cases to take the little ... parents might also feel compelled to buy some pricey toys at ...
(Date:1/14/2014)... 2014 In recent years, growing suspicion ... in product development and promotion has led to unprecedented ... fueled by concerns about the insidious impact of commercialization ... spectacular fines to the world’s biggest pharmas for illegal ...
Breaking Biology Technology:Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3
... Laboratories, pathologist, Ronald L. Weiss, MD, MBA, FCAP, received ... Pathologists at CAP ,11, the organization,s annual meeting, held ... the award honors members "who have made a broad ... of pathology." (Logo: http://photos.prnewswire.com/prnh/20110915/SF69370LOGO ) ...
... 2011 NewCardio, Inc., (OTC BB: NWCI) a cardiovascular ... Clinilabs, will utilize QTinno®, NewCardio,s automated cardiac safety solution, ... new drug under development for a central nervous system ... one important aspect of the trial. Clinilabs, ...
... 2011 Orexigen® Therapeutics, Inc. (Nasdaq: OREX ), ... announced financial results for the third quarter of 2011. For ... net loss of $4.6 million, or $0.10 per share, as ... per share, for the third quarter of 2010. As of ...
Cached Biology Technology:ARUP Laboratories' Pathologist, Ronald L. Weiss, MD, Honored With Lifetime Achievement Award for Contributions to Patient Care and Pathology 2Clinilabs will Conduct Phase 1 Trial Using QTinno® 2Clinilabs will Conduct Phase 1 Trial Using QTinno® 3Clinilabs will Conduct Phase 1 Trial Using QTinno® 4Clinilabs will Conduct Phase 1 Trial Using QTinno® 5Orexigen® Therapeutics Reports Third Quarter Financial Results 2Orexigen® Therapeutics Reports Third Quarter Financial Results 3Orexigen® Therapeutics Reports Third Quarter Financial Results 4Orexigen® Therapeutics Reports Third Quarter Financial Results 5
... ISO 9001:2000 Certified USDA Research Registered OLAW ... Training AALAS Certified Technicians ... GLP Documentation Upon Request Focus ... for all your custom immunology service needs. ...
Human IL-17D Affinity Purified Polyclonal Ab...
BBS/Glycerol/Casein Block and Diluent - 10X Concentrate, 1 L...
... peptide derived from an internal region of ... of rapamycin FRAP RAFT1 RAPT1). Specificity: ... On Western blots it identifies the target ... (positive control: HEK293 cell lysates). Based on ...
Biology Products: