Navigation Links
DNA layer reduces risk of reserve parts being rejected

Dutch researchers Jeroen van den Beucken and John Jansen have given body implants a DNA layer. This layer ensures a better attachment, more rapid recovery of the surrounding tissue and less immune responses. The older we get the more 'reserve-parts' we need. Up until now placing such parts yielded advantages, but also disadvantages such as inflammations and immune responses. Van den Beucken's invention makes it easier and more reliable to use implants and has already been patented.

Van den Beucken reasoned that a DNA coating should have a lot of advantages. Such a coating approximates the body's own material with the result that a less intense immune response occurs. Further DNA is rich in phosphate groups that can speed up the attachment to bone tissue and therefore the integration of bone implants in the native bone tissue. Finally, DNA can be enriched with biologically active factors that, for example, facilitate the formation of bone tissue and blood vessels. All in all, a DNA coating could be safe, reduce the immune response, facilitate bone attachment and be functionalisable.

Layer by layer

However, enzymes in the body will quickly break down a DNA coating. A method therefore had to be found to firmly attach the DNA to the implant surface. Van den Beucken used the Layer-by-Layer deposition technique (see Figure 1) to produce a multilayer coating. This coating was tested in cell cultures and animal experiments for its safety, immune response, bone attachment and functionalisation. The DNA layer was also found to speed up the deposition of calcium phosphate and could, for example, be adapted to promote bone and blood vessel formation. The good research results led to the patenting of DNA coatings for implants. A biomedical company is currently investigating whether they can take over the patent.

Layer-by-Layer deposition technique. With this technique, ultra-thin DNA layers can be built up and immobilized. The first layer attaches to the surface by means of adsorption. The subsequent layers remain in place due to electrostatic interactions. This makes it possible to build up multiple layers with opposite charges. Step 1 positively charged particles, Step 2 washing stage, Step 3 negatively charged particles (DNA), Step 4 washing stage. Click on the image for a larger version

More possibilities

Following this successful result, Van den Beucken will investigate whether DNA layers can be used for the application of DNA membranes to prevent post-operative adhesions, and in biosensors such as an implanted glucose sensor for diabetic patients.


'"/>

Source:Netherlands Organization for Scientific Research


Related biology news :

1. UCSD researchers maintain stem cells without contaminated animal feeder layers
2. Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer
3. Virginia Tech football player uses prototype cast
4. Scientist measures role of sciences coolest player: The snow
5. A biosensor layered like lasagna
6. Common enzyme is a key player in DNA repair
7. Birth rate, competition are major players in hominid extinctions
8. New player in commitment to life as a fat cell
9. Brown cancer biologists identify major player in cell growth
10. Male circumcision reduces risk of HIV transmission from women to men
11. Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2017)... UBM,s Advanced Design and Manufacturing event in ... and evolving technology through its 3D Printing and Smart ... the expo portion of the event and feature a ... on trending topics within 3D printing and smart manufacturing. ... will take place June 13-15, 2017 at the Jacob K. ...
(Date:4/11/2017)... Apr. 11, 2017 Research and Markets has ... report to their offering. ... The global eye tracking market to grow at a CAGR of ... Eye Tracking Market 2017-2021, has been prepared based on an in-depth ... market landscape and its growth prospects over the coming years. The ...
(Date:4/6/2017)... 2017 Forecasts by Product Type ... by End-Use (Transportation & Logistics, Government & Public Sector, ... Fossil Generation Facility, Nuclear Power), Industrial, Retail, Business Organisation ... Are you looking for a definitive report on the ... ...
Breaking Biology News(10 mins):
(Date:4/28/2017)... , ... April 28, 2017 , ... Cynvenio Biosystems, ... launch of a new neoadjuvant breast cancer monitoring (NEAT) study in partnership with Allentown, ... centers and over 150 patients to be monitored over two years with Cynvenio’s ClearID ...
(Date:4/27/2017)... ... April 27, 2017 , ... Oncolinx, a spin-out of the ... has truly taken their cancer research out of this world. On April 22, ... Canaveral to the International Space Station’s (ISS) U.S. National Laboratory, managed by the ...
(Date:4/27/2017)... ... April 27, 2017 , ... Arrowhead Publishers is pleased ... is coming to San Diego, CA on September 27-28, 2017. Leaders from the ... latest advances in the treatment of various types of pain. There are also ...
(Date:4/27/2017)... ... April 27, 2017 , ... ... joined other scientists, researchers, engineers, and industry professionals in visiting U.S. Congressional offices ... to compete in the world photonics industry. , This year, National Photonics ...
Breaking Biology Technology: