Navigation Links
DNA end caps may lead to cancer treatments, UT Southwestern researchers report

The two ends of human DNA have different structures that are treated differently as a cell divides, UT Southwestern Medical Center researchers have found in a study that could help lead to cancer therapies.

The study ?published in the Feb. 3 issue of the journal Molecular Cell ?focuses on the ends of DNA, which are capped by segments called telomeres. Each time the cell divides, the telomeres shorten. When they become too short, the aging cell can no longer divide. But in most cancer cells, an enzyme called telomerase keeps the telomeres from shortening, making the cells immortal and potentially malignant.

"Drugs that influence these mechanisms might be used to slow replicative aging in normal cells and increase the efficacy of telomerase-inhibition therapies for cancer," said Dr. Woodring Wright, professor of cell biology.

In human cells, every chromosome has a telomere at each end, and each telomere ends in a single-stranded overhang. (DNA is normally double-stranded.) The overhang at one end of the chromosome is longer than at the other.

"Understanding the structure of the overhang is clearly very important for our ultimate ability to understand and manipulate these things for a variety of purposes," Dr. Wright said.

The researchers believe that the rate of shortening is influenced by the length of the overhang ?more DNA is lost from ends that have longer overhangs. Telomerase also changed the relative size of the two tails.

"We need to understand how this size is regulated, since we would like to be able to manipulate it for therapeutic purposes," he said.

Dr. Wright and his collaborator, Dr. Jerry Shay, professor of cell biology, are world-renowned for their work on telomeres and telomerase. They helped develop an anti-telomerase drug that helps slow the spread of lung cancer cells in mice. The drug is being tested in humans to see if it's safe.

The researchers say that any anti-telomerase dr
'"/>

Source:UT Southwestern Medical Center


Page: 1 2

Related biology news :

1. Viral DNA sequence a possible trigger for breast cancer
2. Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
3. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
4. Columbia research lifts major hurdle to gene therapy for cancer
5. Combination therapy boosts effectiveness of telomere-directed cancer cell death
6. Mitochondrial DNA mutations play significant role in prostate cancer
7. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
8. BRCA1 causes ovarian cancer through indirect, biochemical route
9. Researchers identify target for cancer drugs
10. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
11. First atlas of key brain genes could speed research on cancer, neurological diseases
Post Your Comments:
(Date:12/17/2014)...  Automation is fundamentally transforming the travel experience and nowhere ... the past decade, ePassports, biometric readers, and secure document ... border control via eGates and Automated Passport Control (APC) ... land borders across the globe. According ...
(Date:12/11/2014)... SALEM, N.C. , Dec. 10, 2014  That blood pressure ... quite a while. Hypertension – the medical term for high ... the early 1800s, and the inflatable cuff that,s used in ... doesn,t, however, mean there,s nothing new about hypertension, its triggers ...
(Date:12/10/2014)... WINSTON-SALEM, N.C. , Dec. 9, 2014  Wake Forest Baptist ... building for its School of Medicine. Funding for this $50 ... that will be publicly launched next summer. ... 60 series R.J. Reynolds Tobacco Company complex, adjacent to 525@vine ...
Breaking Biology News(10 mins):Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4
... If you carried a gene that increased your risk ... know? Do perceptions of stigma and discrimination against people ... disease? Sara Shostak, assistant professor in the department ... of epidemiology at Columbia University, and other collaborators were ...
... - Mercyhurst University biologists have received a $30,000 grant to ... woolly adelgid, a small, aphidlike insect that is decimating the ... considered one of the greatest threats to our eastern forests; ... Georgia," said Michael Elnitsky, assistant professor of biology, who wrote ...
... Institute at Oregon State University have discovered yet another reason ... is so good for you it provides not just ... mechanism of epigenetics. Epigenetics, an increasing focus of research ... but also to the way that diet, toxins and other ...
Cached Biology News:Grant to fund research into psychosocial impacts of epilepsy testing 2Grant to fund research into psychosocial impacts of epilepsy testing 3Mercyhurst research aims to predict impact of invasive forest pest 2Another mechanism discovered by which sulforaphane prevents cancer 2
(Date:1/22/2015)... 22, 2015 Controlled Substance Compliance Services ... helps companies check the legal requirements around using controlled ... China. , As their international operations expand and ... software solutions built as a result of the first ...
(Date:1/22/2015)... , Nueva Jersey , 22 de enero de ... Biomedical Research abre hoy su llamada a nominaciones para ... investigación científica ha hecho, o tiene el potencial para ... humana. Las nominaciones se aceptarán hasta el 15 de ...
(Date:1/22/2015)... CAMBRIDGE, Mass. , Jan. 22, 2015   GenoSpace , ... suite of tools to enable the broad use of genomic, ... today announced the appointment of Michelle Munson , CEO ... independent director. Logo - http://photos.prnewswire.com/prnh/20150122/170713 ...
(Date:12/24/2014)... , Dec. 24, 2014  United Therapeutics Corporation (NASDAQ: ... MDT ) has submitted a pre-market approval ... for the use of Medtronic,s SynchroMed ® II ... for use with United Therapeutics, Remodulin ® (treprostinil) ...
Breaking Biology Technology:Global Compliance Service for Controlled Substances to Expand to China 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4GenoSpace Expands Board with Appointment of Michelle Munson 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4
... Oct. 29 Genomas(R) today announced,that Gualberto Ruano, ... the Life,Sciences & Healthcare Venture Summit in New ... ET. Dr. Ruano,s presentation, Bringing DNA-Guided Medicine to,the ... update on the,Company,s programs in cardiovascular medicine (statins) ...
... Chicago fertility solutions agency,believes it has a win/win proposition ... effects of a free-falling economy: If you otherwise meet,the ... on public,aid, but don,t have health insurance, we want ... matches infertile intended,parents with both egg donors and the ...
... a cell-based clinical trial that may have far-reaching implications for future ... ... 29, 2008 -- Singapore has embarked on a cell-based clinical trial ... , , , ,The trial, currently ongoing, involves up to 35 ...
Cached Biology Technology:Fertility Agency Sweetens Incentives to Gestational Surrogates; Finds Interest Up 2Singapore Medicine - Breakthrough Development of Cell Therapy Treatment for Cancer 2Singapore Medicine - Breakthrough Development of Cell Therapy Treatment for Cancer 3Singapore Medicine - Breakthrough Development of Cell Therapy Treatment for Cancer 4
Umbilical cord blood CD19+ B cells, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Monocytes, B Cells and NK Cells...
Umbilical cord blood CD4+ T cells, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood MNCs and T Cells...
Human peripheral blood CD56+ NK cells, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Monocytes, B Cells, NK Cells and Stem Cells...
Yeast tRNA 50 l...
Biology Products: