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DNA-damage test could aid drug development

may be able to extend the technique to humans. Humans are the gold standard in that one wants an assay that directly predicts toxicity in humans, not animals, and you could obtain human bone marrow that's left over from medical procedures."

"If you could change the micronucleus assay to have a human cell readout, that would be pretty amazing," says Samson. Down the road, she suggests, such a test might offer a new way to examine how different individuals respond to chemotherapeutic agents.

"The presumption is that, for some biological processes, in vitro human models could be closer to in vivo human than in vivo mouse," notes Shuga. "That premise will be tested in coming years as new systems become available."


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Source:Whitehead Institute for Biomedical Research


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