Navigation Links
DNA-damage test could aid drug development

om an established cell-culture system based on mouse fetal liver cells to create a new system based on adult red cell precursors from mouse bone marrow. Shuga patiently optimized the system, which allows the precursor cells to proliferate and differentiate in the normal way, dividing four or five times before losing their nucleus and becoming immature red blood cells.

Shuga then studied the way these developing cells reacted to three toxic DNA- damaging agents whose effects had been studied by Samson's lab, and found the results correlated well with results from the existing test. Additionally, he experimented with mutant mice created by Samson's lab that are deficient in certain DNA-repair systems. The bone marrow cells derived from these mice, and the cells cultured from that bone marrow, proved more sensitive to the toxic agents than were the cultured cells from normal mice, further confirming the results.

With the new assay, "instead of testing one chemical and one dose in one animal, you'll be able to take one animal, get the bone marrow out and test a thousand different conditions," Samson says. "You'll be able to look in more detail at different doses given at different times in the cell differentiation process."

"This is a much cheaper assay that's at least as predictive as previous assays," emphasizes Griffith, "and drug developers can afford to use it a lot earlier in the drug development process." It also could help to avoid issues with animal testing. "The European Union is trying to minimize animal testing," Shuga points out. "A ban on animal testing of cosmetic products goes into effect in 2009."

Next steps in the research, which may be carried out by industry partners, will be to test the assay in rats and other organisms, and with a wide variety of other toxic chemicals.

"This research is the first stage in a new type of clinical drug toxicity test," says Lodish. "And although we haven't done it, you
'"/>

Source:Whitehead Institute for Biomedical Research


Page: 1 2 3

Related biology news :

1. Protein discovery could unlock the secret to better TB treatment
2. Tiny particles could solve billion-dollar problem
3. First atlas of key brain genes could speed research on cancer, neurological diseases
4. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
5. A comprehensive response to HIV could prevent 10 million AIDS deaths in Africa by 2020
6. How the environment could be damaging mens reproductive health
7. Dead zone area in Gulf could be increasing, researchers say
8. Growth in biomass could put US on road to energy independence
9. Nano-bumps could help repair clogged blood vessels
10. Researchers develop assay that could be applied to drug screening
11. Currents could disrupt ocean food chain
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: DNA damage test could aid drug development

(Date:12/17/2014)... is fundamentally transforming the travel experience and nowhere is ... past decade, ePassports, biometric readers, and secure document scanners ... control via eGates and Automated Passport Control (APC) Kiosks ... borders across the globe. According to ...
(Date:12/11/2014)... Research and Markets , ... announced the addition of the "Biometrics Market in ... One major trend emerging in this market ... it is important to upgrade biometric solutions to the ...
(Date:12/11/2014)... N.C. , Dec. 10, 2014  That blood pressure plays ... a while. Hypertension – the medical term for high blood ... early 1800s, and the inflatable cuff that,s used in measuring ... however, mean there,s nothing new about hypertension, its triggers and ...
Breaking Biology News(10 mins):Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4
... ROCKVILLE, Maryland July 9, 2009 Human Genome ... New England Journal of Medicine of the ... the life-saving potential of the Company,s human monoclonal antibody ... human safety studies, which supported the use of raxibacumab ...
... conducted at the University of Houston may offer important ... levels and help regulators determine whether existing fish-consumption advisories ... way, the UH engineering team,s project is entering a ... from Galveston Bay and related waterways. Cullen ...
... appearing in Environmental Health Perspectives (EHP) ... for the Project on Emerging Nanotechnologies (PEN), focuses ... It provides an overview of current practices; ... safety implications; and possible future directions for nanoremediation. ...
Cached Biology News:Data published in the New England Journal of Medicine support use of raxibacumab (ABthrax) for the treatment of inhalation anthrax 2UH team analyzes Hurricane Ike's effects on waterways, fish contamination 2UH team analyzes Hurricane Ike's effects on waterways, fish contamination 3Contaminated site remediation: Are nanomaterials the answer? 2
(Date:1/22/2015)... 22, 2015 Pipette.com has added the ... their comprehensive portfolio of Eppendorf products. , The Eppendorf ... a Centrifuge 5424/5424 R and receive the following:, ... Research plus or Eppendorf Reference 2 , ...
(Date:1/22/2015)... Switzerland (PRWEB) January 22, 2015 Selexis ... characterized mammalian Research Cell Banks (RCBs) used for drug ... Research Cell Banks will include Next-Generation Sequencing ... genetic architecture de-risks biologic manufacturing by ensuring the integrity ...
(Date:1/22/2015)... , Jan. 22. 2015  Varian Medical Systems (NYSE: ... been honored for its commitment to sustainability with inclusion on ... is the highest ranked healthcare equipment company among the Corporate ... the World Economic Forum at Davos, Switzerland ...
(Date:12/24/2014)... 24, 2014  United Therapeutics Corporation (NASDAQ: UTHR ... MDT ) has submitted a pre-market approval application to ... use of Medtronic,s SynchroMed ® II implantable drug ... with United Therapeutics, Remodulin ® (treprostinil) Injection delivered ...
Breaking Biology Technology:Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2Varian Honored Among World's 100 Most Sustainable Corporations 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4
... , WILMINGTON, Del. and ... AZN ) and the University of Virginia (UVa) in ... strategic research collaboration to enhance development of new treatments ... focus on peripheral vascular disease (PAD). , (Logo: ...
... , , , ... for Medical Publication Professionals (ISMPP) today announced that the professional ... Meeting, which is being held in Arlington, VA, April 19-21, ... encouraging non-members to join the organization to submit an abstract ...
... and LONDON, Dec. 15 Thomson ... the first drug pipeline database to fully integrate detailed clinical ... is being provided to all Thomson Pharma customers this month. ... related clinical trial intelligence from registries, publications, press releases, conferences, ...
Cached Biology Technology:AstraZeneca and the University of Virginia Sign Strategic Research Collaboration to Develop Novel Treatments for Cardiovascular Disease 2AstraZeneca and the University of Virginia Sign Strategic Research Collaboration to Develop Novel Treatments for Cardiovascular Disease 3The International Society for Medical Publication Professionals Announces Call for Abstracts for Its 6th Annual Meeting 2The International Society for Medical Publication Professionals Announces Call for Abstracts for Its 6th Annual Meeting 3Thomson Reuters is First to Offer Fully Integrated Pipeline and Clinical Trials 2
The VersArray hybridization chamber is used for manual (coverslip) hybridization of microarrays. The chamber accommodates 2 slides and is watertight to allow incubation of slides in a water bath. Dim...
5X StabilCoat Immunoassay Stabilizer is a 5X concentrate solution of StabilCoat Immunoassay Stabilizer. The shelf-life of 5X StabilCoat Immunoassay Stabilizer is 2 years when stored at 4C. Product ...
... Yellow crystalline solid. PROTECT FROM LIGHT. Useful ... not required. Purity: ≥98% by TLC. Soluble ... systems, preparation of a 10 mM stock in DMSO ... added to H 2 O with rapid mixing (e.g. ...
Monoclonal antibodies conjugated with rhodamine...
Biology Products: