Navigation Links
DNA Recombination and Repair—A New Twist to RecA Function

Molecular motors harness the energy of ATP (or GTP, a related energy currency) and transform it into mechanical force. Well-known examples of motors include myosin and dynein, proteins that use ATP to ferry intracellular cargo along fibers made of actin or tubulin proteins. The ATP-dependent assembly of actin or tubulin fibers itself can work as a motor: for instance, the march of white blood cells toward pathogens is powered by the growth of actin filaments pushing against the cells?membranes. In all cases, coherent motion implies a coordinated and polarized use of energy.

Now, Julia Cox, Oleg Tsodikov, and Michael Cox present evidence indicating that filaments of the bacterial RecA protein, long known for their role in homologous recombination and DNA repair, have properties reminiscent of a molecular motor as well. RecA filaments consist of DNA helices lined with RecA protein. RecA filaments invade a region of double-stranded DNA with similar nucleotide sequence, displacing one strand to pair with the other. Strand invasion can lead to a re-assortment—known as recombination—of DNA regions on either side of the shared sequence. It can also initiate the repair of DNA lesions during replication—the process by which a DNA molecule is copied to make two.

RecA is also an ATPase, an enzyme capable of hydrolyzing (breaking down) ATP, when bound to DNA. RecA uses ATP to carry out strand exchange over long sequences and impose direction to the exchange, to bypass short sequence heterogeneities, and to stall replication so DNA lesions can be mended. But how RecA molecules within a filament coordinate and organize their activities to carry out these functions has remained obscure.

Cox et al. addressed this problem in the test tube, by examining RecA filaments grown from mixing RecA protein with DNA. Previous experiments have shown that filament assembly spreads rapidly in the 5'-to-3' direction once the first RecA molecule is loaded onto DNA. At the sa
'"/>

Source:PLoS Biology


Page: 1 2

Related biology news :

1. Recombination protein dynamics observed with single monomer resolution
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: DNA Recombination and Repair New Twist RecA Function

(Date:10/30/2014)... 30 October 2014 Biological membranes are mainly composed ... adsorption of solution ions onto lipid membranes helps ... new study provides a quantitative description of the ... Joanna Kotyńska and Zbigniew Figaszewski from the University ... study describing these findings, just published in ...
(Date:10/29/2014)... their hair as a consequence of chemotherapy will benefit ... scalp cooling technology that prevents hair loss. , The ... by global scalp cooling manufacturing company, Paxman Coolers, of ... of the University of Huddersfield. , The research will ... a background in the pharmacology of cancer treatment, which ...
(Date:10/29/2014)... Online registration is open for the ... Scientific Meeting. SIR 2015 is the one ... trainees and related health care professionals can ... image-guided science and technologies being presented, discussed ... community in minimally invasive, image-guided medicine, SIR ...
Breaking Biology News(10 mins):Ion adsorption matter in biology 2New technology on the way to aid cancer suffers who lose their hair after chemotherapy 2SIR 2015: Interventional radiology shapes tomorrow's medicine 2
... is the life-blood of agriculture; it is the liquid elixir ... needed to feed the world. The ample supply of water ... and famine. Many parts of the world, however, suffer from ... agriculture. The reasons can range from drought and desertification to ...
... of experts from the Society for Healthcare Epidemiology (SHEA) ... released online new clinical practice guidelines for Clostridium ... to be published in the May issue of ... the epidemiology, diagnosis, treatment and infection control and environmental ...
... The brains of males and females, and how they use ... least in the fruit fly Drosophila melanogaster , according ... paper published today in the journal Nature Neuroscience , ... Oxford, have shown that the gene known as ,doublesex, (dsx), ...
Cached Biology News:More water for life 2More water for life 3New guidelines for diagnosing, managing and treating Clostridium difficile 2Sex on the brain: 'Doublesex' gene key to determining fruit fly gender 2Sex on the brain: 'Doublesex' gene key to determining fruit fly gender 3
(Date:10/27/2014)... , October 27, 2014 Investor-Edge ... Inc. (NASDAQ: NBIX ), Insmed Inc. (NASDAQ: ... BCRX ), Dyax Corporation (NASDAQ: DYAX ... these five companies can be accessed at: http://investor-edge.com/register ... NASDAQ Composite ended at 4,483.72, up 0.69%, the Dow ...
(Date:10/26/2014)... The report "Protective Coatings Market by ... Trends & Forecast to 2019", defines and segments the ... volume consumed and value generated. The protective coatings consumption ... to 6,701.3 KT by 2019, at a CAGR of ... data tables and 22 figures spread through 219 slides ...
(Date:10/25/2014)... Angeles, California (PRWEB) October 23, 2014 ... ), a specialty pharmaceutical company devoted to bringing ... out-licensing partnerships in 2015. , ViaDerma has developed ... which allows for rapid mass transfer of pharmaceutical ... the body to provide immediate localized therapy. The ...
(Date:10/25/2014)... According to new market research report "Data ... Enterprise, Telecom), by Design Types (Electrical, Mechanical), and ... 3, Tier 4) - Global Forecast to 2019", ... Center Construction Market into various segments with an ... report also identifies the factors driving this market, ...
Breaking Biology Technology:Pre-market Equity Watch on Biotech Industry - Neurocrine Biosciences, Insmed, BioCryst Pharma, Dyax, and Oncothyreon 2Pre-market Equity Watch on Biotech Industry - Neurocrine Biosciences, Insmed, BioCryst Pharma, Dyax, and Oncothyreon 3Pre-market Equity Watch on Biotech Industry - Neurocrine Biosciences, Insmed, BioCryst Pharma, Dyax, and Oncothyreon 4Pre-market Equity Watch on Biotech Industry - Neurocrine Biosciences, Insmed, BioCryst Pharma, Dyax, and Oncothyreon 5Protective Coatings Market Poised to Reach $18,431.8 Million by 2019 - Report by MarketsandMarkets 2Protective Coatings Market Poised to Reach $18,431.8 Million by 2019 - Report by MarketsandMarkets 3Protective Coatings Market Poised to Reach $18,431.8 Million by 2019 - Report by MarketsandMarkets 4ViaDerma, Inc. Announces Plans to Pursue Out-Licensing Partnerships in 2015 2ViaDerma, Inc. Announces Plans to Pursue Out-Licensing Partnerships in 2015 3Data Center Construction Market Worth $22.73 Billion by 2019 - New Report by MarketsandMarkets 2Data Center Construction Market Worth $22.73 Billion by 2019 - New Report by MarketsandMarkets 3Data Center Construction Market Worth $22.73 Billion by 2019 - New Report by MarketsandMarkets 4
... CAMBRIDGE, Mass., Nov. 18 Knome, Inc., a ... announced the launch of KnomeDISCOVERY, the first fully ... for researchers. The new offering meets rapidly emerging ... that bundles affordable, research-tailored access to a broad ...
... LONDON, November 18 , - ... - An Estimated Two Billion Work Hours Lost Each Week , ... first time that,people between the ages of 40 to 65 are emerging as ... experts, the,report uncovers a new, younger majority of COPD patients(1) who are in ...
... ... Sonitor,s Ultrasound identification (USID) technology is now including Wi-Fi to enable the ultimate hospital ... , ... November 18, 2009 -- One of the many advantages of Sonitor,s recently released High ...
Cached Biology Technology:Knome Launches First Platform-Agnostic Human Genome Sequencing and Analysis Service for Researchers 2Knome Launches First Platform-Agnostic Human Genome Sequencing and Analysis Service for Researchers 3Mainstay of the Global Workforce - 40-65 Year Olds - Hit Hardest by Chronic Obstructive Pulmonary Disease (COPD) 2Mainstay of the Global Workforce - 40-65 Year Olds - Hit Hardest by Chronic Obstructive Pulmonary Disease (COPD) 3Mainstay of the Global Workforce - 40-65 Year Olds - Hit Hardest by Chronic Obstructive Pulmonary Disease (COPD) 4Hand-washing Compliance, Computer Auto Log-on/ Log-off and Patient Fall-detection are Enabled by Real Time Location System (RTLS) with Sub-room Location Accuracy 2Hand-washing Compliance, Computer Auto Log-on/ Log-off and Patient Fall-detection are Enabled by Real Time Location System (RTLS) with Sub-room Location Accuracy 3Hand-washing Compliance, Computer Auto Log-on/ Log-off and Patient Fall-detection are Enabled by Real Time Location System (RTLS) with Sub-room Location Accuracy 4
Request Info...
Multidrop Micro high speed 1 l bulk reagent dispenser rapidly, precisely and accurately dispenses microvolumes of 1-50 l into 384- and 96-well microplates....
...
...
Biology Products: