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DDT-resistant insects have additional genetic advantage that helps resistance spread

r World War II, primarily because of its effectiveness against the mosquito that spreads malaria and lice that carry typhus.

DDT-resistant mosquitoes were first detected in India in 1959, and they have increased so rapidly that when a local spray program is begun now, most mosquitoes become resistant in a matter of months rather than years.

Worryingly, some resistant strains also show 'cross-resistance' to a number of different compounds, so spraying with one insecticide can unexpectedly increase resistance to newer compounds subsequently introduced to try and overcome resistance.

The World Health Organization estimates that during the period of DDT use, approximately 25 million human lives have been saved. Today pyrethroids are most commonly used in mosquito control but they act on the same target in the nervous system as DDT and ironically spraying with DDT may therefore have pre-selected for resistance to the newer pyrethroids.


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Source:University of Bath


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