Navigation Links
Cyclosporine inhibits hepatitis C virus in vitro

duction with Tacrolimus. Furthermore, the Cyclosporine appeared to work through a different pathway compared to interferon.

Then, the researchers retrospectively examined the cases of 115 people infected with hepatitis C who had undergone liver transplantation at the University of Florida between 1991 and November 2002 and had received interferon-based therapy alongside their anti-rejection medications. After 48 weeks, 46 percent of the patients taking Cyclosporine had achieved a sustained virological response, compared with just 27 percent of the patients taking Tacrolimus.

"Our study suggests that Cyclosporine may play a beneficial role as primary immunosuppression for patients transplanted for HCV infection and may offer an advantage to Tacrolimus in those patients undergoing IFN-based therapy," the authors report. In addition, they confirm antiviral activity by the drug in cell cultures, having found that, "combination of Cyclosporine and interferon achieve better antiviral effect than either one alone."

Of note, considerably more patients taking Tacrolimus had to reduce or stop the therapy due to side effects. Also of possible significance, more patients taking Cyclosporine died, mostly due to infections and hepatitis complications, though this may be attributable to a longer follow-up period for that group.

Still, the indication that Cyclosporine had novel antiviral properties invites further investigation, the authors write. A prospective randomized comparative trial between cyclosporine and TAC should further evaluate their observations.

"Due to the accelerated rate of disease progression and graft failure after liver transplantation in HCV patients," the authors conclude, "it will be very important to determine the ideal immunosuppression regimen."


'"/>

Source:John Wiley & Sons, Inc.


Page: 1 2

Related biology news :

1. Novel antiviral technology inhibits RSV infection in mice
2. Researchers find molecule that inhibits regrowth of spinal nerve cells
3. Techniques available to detect soil that inhibits destructive soybean pest
4. Chemical compound inhibits tumor growth, size in new mouse study
5. Dartmouth study finds that arsenic inhibits DNA repair
6. Viral hitchhiker inhibits Wolbachia bacterias ability to proliferate
7. Activation of microRNA inhibits cancer gene in human cancer cells
8. Study IDs protein that inhibits HIV from growing in cell cultures
9. Gene therapy inhibits epilepsy in animals
10. Antibiotic inhibits cancer gene activity
11. Multiple malaria infection inhibits spread of parasite
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Cyclosporine inhibits hepatitis virus vitro

(Date:4/17/2014)... If a restaurant ... he can expect his premises to be trashed. Warnings like ... is enough to make restaurant owners pay up. Similarly, mafia-like ... in other birds, nests. If the host birds throw the ... destroying the entire nest. Consequently, it is beneficial for hosts ...
(Date:4/17/2014)... IPCC meeting painted a stark warning on the possible ... a greenhouse effect 32 times that of carbon dioxide. ... humic substances act as fully regenerable electron acceptors which ... in wetlands instead of being released to the atmosphere. ... disrupted it may enter into a vicious cycle to ...
(Date:4/17/2014)... wild animals and plant life, but there,s an invisible ... in the soil, decomposing organic matter and releasing carbon ... fungi play in ecological systems, their identities have only ... generated a genetic map of more than 10,000 species ... this week in the Proceedings of the National ...
Breaking Biology News(10 mins):Fear of the cuckoo mafia 2Fear of the cuckoo mafia 3Methane climate change risk suggested by proof of redox cycling of humic substances 2Stanford biologists help solve fungal mysteries 2Stanford biologists help solve fungal mysteries 3
... on earth is threatened by chaos. In this sense, a ... sink in a sea of chaos. It must constantly consume ... going under metaphorically speaking, the infiltrating water of chaos ... Planck Institute of Molecular Physiology in Dortmund have now discovered ...
... 2010-Conventional agriculture production relies heavily on fossil fuels, particularly ... cost. However, the uncertain future of fossil fuel availability ... in other cropping systems. Most of the U.S. ... and soybean with heavy inputs of fertilizer, herbicides and ...
... April 28, 2010 In findings that could one day lead ... described some striking differences between the biochemistry of stem cells ... Associate Professor Sheng Ding and Senior Director of the Scripps ... an advance, online edition of the prestigious journal Nature ...
Cached Biology News:Transportation governed by simple rules 2Transportation governed by simple rules 3Transportation governed by simple rules 4Reducing fossil energy use on the farm 2Reducing fossil energy use on the farm 3Scripps Research team provides groundbreaking new understanding of stem cells 2Scripps Research team provides groundbreaking new understanding of stem cells 3
(Date:1/14/2014)... Carahsoft and CDS Federal Services have ... at 2pm EST (11am PST), “Natural Language Processing: Converting ... how technology can turn raw, heterogeneous data into actionable ... The online webinar will last approximately one hour. , ...
(Date:1/14/2014)... , Jan. 14, 2014 The largest ... research medicinal plants and therapeutic derivatives thereof has ... professionals, and researchers about the challenges of adulterated ... http://photos.prnewswire.com/prnh/20100430/DC95601LOGO ) The Society for ...
(Date:1/14/2014)... 2014 Global Record Systems, LLC, ... technology solutions for patients, physicians, the biopharmaceutical industry, ... today the signing of a three-year Research Collaboration ... Administration (FDA). This initiative is designed to ...
(Date:1/14/2014)... Altadena, CA (PRWEB) January 14, 2014 ... Angeles County), California, and Montreal, Canada, has big ideas ... and non-fiction. The press's goals are to produce high-quality, ... e-books to support local businesses. , The first ...
Breaking Biology Technology:Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2Bitingduck Press Looks Forward to 2014 With Multimedia E-books 2
... announced today it has been chosen again ... of Wisconsin-Madisons Camp Randall Stadium and Kohl Center arena. ... the South Dakota-based company in the early 1990s. The ... scheduled to be complete before the start of the ...
... - Inacom Education , announced today that it is ... Microsoft Technology Trainers United Training. United Training ... training centers from around the country who have met an ... , , In order to qualify for membership, ...
... with attachments containing sensitive corporate information not intended for ... on a stolen notebook computer or sent by a ... Serious legal ramifications and breaches of national security may ... the recent DEMO 2004 conference, Adobe Systems recently introduced ...
Cached Biology Technology:Daktronics to provide Camp Randall and Kohl Center with scoreboards, display systems 2New solution protects corporate information 2
... High pH, Concentrated x 10 This ... target retrievel prior to immunohistochemical staining procedures. ... tissue sections mounted on glass slides. For ... 9.9, is especially effective. It should be ...
... off-white solid. Increases the expression of glutathione peroxidase. ... H 2 O. Unstable in aqueous solutions; ... CAS 3211-76-5, M.W. 196.1. References: Merck ... Junod, A.F. 1995. Biochem. J. ...
... UN-SCAN-IT gel Software converts any scanner into ... numerous options and features, the basic operation ... JPEG, PCX, BMP, etc.) into pixel density ... steps. Turn your scanner ...
The BioLogic Maximizer mixer is for use with the Maximizer valve system. The mixer improves gradient quality by mixing the output of the BioLogic DuoFlow workstation pumps....
Biology Products: