Navigation Links
Cyclosporine inhibits hepatitis C virus in vitro

Liver transplant patients with hepatitis C virus (HCV) achieved significantly better long-term viral response when taking the immunosuppressive agent Cyclosporine along with interferon-ribavirin combination therapy. Cyclosporine also showed efficacy against Hepatitis C virus in vitro.

The results of this study appear in the January 2006 issue of Liver Transplantation, the official journal of the American Association for the Study of Liver Diseases (AASLD) and the International Liver Transplantation Society (ILTS). The journal is published on behalf of the societies by John Wiley & Sons, Inc. and is available online via Wiley InterScience (http://www.interscience.wiley.com/journal/livertransplantation).

Hepatitis C always recurs after liver transplantation, often damaging the new organ and rendering patients ineligible for retransplantation. To address this problem, patients with hepatitis C often undergo interferon-ribavirin combination therapy after receiving a liver transplant in hopes of a sustained virologic response. At the same time, of course, the patients must take immunosuppressive agents to guard against transplant rejection.

The most commonly used anti-rejection medication is Tacrolimus, although Cyclosporine is also used. The latter drug has been shown to have anti-viral activity against HIV, herpes simplex and vaccinia virus, leading researchers to speculate it might also inhibit hepatitis C virus. To examine this hypothesis, they analyzed the impact of the drug in a liver transplant population. They also studied its effect on hepatitis C in vitro.

For the in vitro study, the researchers, led by Roberto J. Firpi, M.D. of the University of Florida, treated the HCV replicon line, GSB1, with varying doses of Cyclosporine for 48 hours and examined the results. They found that Cyclosporine reduced HCV replication by 20 percent, compared to no re
'"/>

Source:John Wiley & Sons, Inc.


Page: 1 2

Related biology news :

1. Novel antiviral technology inhibits RSV infection in mice
2. Researchers find molecule that inhibits regrowth of spinal nerve cells
3. Techniques available to detect soil that inhibits destructive soybean pest
4. Chemical compound inhibits tumor growth, size in new mouse study
5. Dartmouth study finds that arsenic inhibits DNA repair
6. Viral hitchhiker inhibits Wolbachia bacterias ability to proliferate
7. Activation of microRNA inhibits cancer gene in human cancer cells
8. Study IDs protein that inhibits HIV from growing in cell cultures
9. Gene therapy inhibits epilepsy in animals
10. Antibiotic inhibits cancer gene activity
11. Multiple malaria infection inhibits spread of parasite
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Cyclosporine inhibits hepatitis virus vitro

(Date:7/11/2014)... at the Department of Energy,s Oak Ridge National ... by R&D Magazine in recognition of the year,s ... the tremendous value of our National Labs," said ... at the National Labs continues to help our ... scientific and technological innovations necessary to remain globally ...
(Date:7/11/2014)... Bone and Mineral Research awarded Michael F. Holick, PhD, ... the 2014 Louis V. Avioli Award. Holick, a professor ... known for revolutionizing the understanding of vitamin D and ... honors a member of the American Society for Bone ... and mineral basic research. It is named for ASBMR,s ...
(Date:7/11/2014)... Cell scientists have set a "mouse TRAP" to capture ... a recent study published in the Journal of ... a technique called TRAP to extract cellular and genetic ... by scientists at the Rockefeller Institute for Medical Research ... the protein-making machinery, or ribosomes, of the cell type ...
Breaking Biology News(10 mins):ORNL wins eight R&D 100s 2ORNL wins eight R&D 100s 3ORNL wins eight R&D 100s 4BUSM's Michael F. Holick receives American Society for Bone and Mineral Research award 2
... Scientists propose developing an environmentally-friendly fungal spray that would ... a critical growth stage. This spray will contain ... and will have no side-effects on non-target organisms and ... therefore provide a quick, safe and effective means for ...
... the Technion Israel Institute of Technology, the ... have recently identified genes responsible for the positive ... drug Copaxone®. These findings may contribute to the ... Copaxone® was the first original Israeli drug ...
... -- A new book by researchers at the ... the mouse demonstrates a surprising similarity between mice and humans. ... by a team from the Hebrew University Bone Laboratory consisting ... Hajbi-Yonissi and Dr. Yankel Gabet. Also participating in the writing ...
Cached Biology News:New hope for horse lovers as effective control for killer ragwort is proposed 2Israeli scientists identify: Genes that affect responses of multiple sclerosis patients to copaxone 2Of mice and men: similarities between skeletons of both 2
(Date:7/11/2014)... 2014 Research and Markets  has announced ... - Global Industry Analysis, Size, Share, Growth, Trends and ... http://photos.prnewswire.com/prnh/20130307/600769 Transfection ... DNA or RNA) into cells. This technology helps the ... and protein metabolism by affecting the nuclear genes. The ...
(Date:7/11/2014)... July 11, 2014  Researchers have pioneered a ... The new technology, called Virtual Finger, allows scientists ... like neurons and synapses using the flat surface ... makes 3D imaging studies orders of magnitude more ... unprecedented level across many areas of experimental biology. ...
(Date:7/10/2014)... (PRWEB) July 10, 2014 Deep ... Century Medicine Forum on ‘Commercialising Longevity Research’ and ... entrepreneurs to the London Bioscience Innovation Center for ... Foundation and Aging Analytics Ltd. The meeting highlighted ... in translational research for age-related disease, as well ...
(Date:7/10/2014)... Poway, CA (PRWEB) July 10, 2014 Robert ... Regenerative Veterinary Medicine company, is proud to announce the relaunch ... Pets, launching with a new series called “ What are ... to give an honest and straightforward foundation in the basics ... an educated decision on the right type of treatment when ...
Breaking Biology Technology:International Transfection Technology Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2019 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 2DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 4DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 5DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 6Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3
... 19 /PRNewswire-FirstCall/ - ARIUS Research Inc., (TSX:,ARI), a ... of,antibody therapeutics, today announced that David Young, MD, ... at the Chinese Global,Financial Forum. Dr. Young will ... will be available prior to and following his ...
... ... WEST HAVEN, Conn., Oct. 19 Dr. Heather Coyle ... Haven have,developed a new method for preparing certain skeletal remains ... the,research the group is doing for the Smithsonian Institution. Obtaining ...
... Therapeutics Inc., a,Nutritional Therapeutics Innovation Company, today announced ... Wakeman as President. "Pilot has always had ... and dietary supplement areas with over 60 issued ... potential to rapidly move our,world class technologies and ...
Cached Biology Technology:ARIUS to present at Chinese Global Financial Forum 2800-Year-Old Mummies Aid Current Cold Cases: 2Pilot Therapeutics Announces New Executive Team with Extensive Experience Creating New Health and Nutrition Businesses 2
... exciting product for cell-based kinetic assays and ... use of expensive HTS equipment, which lead ... assay development stage. The NOVOstar offers the ... well as any other assay suitable for ...
... measures mitochondria intactness and detects events ... Features and Benefits: Fast, ... isolated mitochondria and for assaying mitochondria ... reagents required for the detection of ...
... save space and organize gloves, ... other garb. They are the ... small parts used in labs, ... Open-slot design for easy cleaning. ...
... handy dispensers save space and ... hats, and other garb. They ... bins for small parts used ... Clear acrylic. Many other sizes ...
Biology Products: