Navigation Links
Cycles of cell death, proliferation key to liver cancer

Research at the University of California, San Diego (UCSD) School of Medicine shows that liver cancer is likely caused by cycles of liver cell death and renewal.

The research, appearing online the week of June 19 in advance of publication in the journal Proceedings of the National Academy of Sciences, underscores the importance of JNK1-mediated cell death and compensatory proliferation. The findings by Michael Karin, Ph.D., professor pharmacology in UCSD¡¦s Laboratory of Gene Regulation and Signal Transduction, and colleagues strongly suggest that the control of tissue renewal through the IKK and JNK pathways plays a key role in liver cancer in mouse models.

One link between inflammation and cancer is known to involve the NF-kB pathway, which regulates gene expression. In research published in the journal Cell in 2005, Karin and his colleagues at UCSD implicated the pathway's activator, IKK , in chemically induced liver cancer. However, the surprising outcome of those studies was the finding that while NF-ƒÛB activation in hepatocytes (liver cells) prevents liver cancer, its activation in inflammatory cells, such as tissue macrophages, promotes tumor development.

In their latest work, the research team studied what precedes inflammation ¡V the injury of hepatocytes caused by toxic chemicals, which sets in motion the inflammation process.

Their research showed that the absence of IKKƒÒ in hepatocytes led to increased c-Jun N-terminal kinase (JNK) activation after exposure to a chemical carcinogen used to elicit liver cancer in mice. Importantly, deletion of the gene that codes for the major isoform of JNK in liver cells, JNK1, prevented the development of liver cancer and reversed the tumor-enhancing effect caused by ablation of IKKƒÒ.

"We found that long-term JNK activation leads to cell death; if activated briefly, it stimulates proliferation of pre-malignant and cancerous tumor cells," said Karin. Blocking JNK prevents
'"/>

Source:University of California - San Diego


Page: 1 2

Related biology news :

1. Enzyme allows B cells to resist death, leading to leukemia
2. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
3. New methods of gene delivery using lasers
4. UNC launches study of liver injury caused by drugs
5. Gene therapy cures inherited liver disease in rats
6. Mouse with designer liver has enhanced glucose tolerance, insulin response
7. Excess liver gene protects against high-fat diet
8. Recombinant DNA technology may enable oral, rather than injectable, delivery of protein drugs
9. Self-assembled DNA buckyballs for drug delivery
10. Insulin pulses keep the liver lean
11. New research could help us deliver genes for new bone formation
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Cycles cell death proliferation key liver cancer

(Date:7/29/2014)... As the climate warms and sea ice retreats, the ... season of increasingly open water which is predicted to ... of this century. Storms thus have the potential to ... a new and unpredictable element to the region. , A ... waves in the middle of the Arctic Ocean, and ...
(Date:7/29/2014)... a restaurant, don,t blame yourself; blame the menu. What ... want and more to do with a menu,s layout and ... over 300 diners, the Cornell study published this month in ... when it comes to what you order for dinner, two ... how you imagine it will taste. , First, any food ...
(Date:7/29/2014)... Scale plays a major role in locomotion. Swimming microorganisms, ... small inertial forces compared to the viscous forces exerted ... self-propulsion a major challenge. Now, scientists have found that ... is opposite to that induced by a viscoelastic fluid. ... by Franois Nadal from the Alternative Energies and ...
Breaking Biology News(10 mins):Huge waves measured for first time in Arctic Ocean 2Huge waves measured for first time in Arctic Ocean 3Menu secrets that can make you slim by design 2Optimum inertial self-propulsion design for snowman-like nanorobot 2
... Scripps Health announced today it has launched an innovative ... help determine the causes of idiopathic human diseases -- those ... or are unresponsive to standard treatments. The use of ... and treating rare medical cases. Whole genome sequencing provides ...
... identified and mapped the chemical structure of molecules used by ... growth of reef-building coral. Chemicals found on the surfaces ... coral, suggesting that competition with these macroalgae could be a ... of coral reefs. Seaweed growth on coral reefs ...
... difficult to measure accurately each nation,s contribution of carbon dioxide ... ground as coal, gas, and oil, and these fuels are ... generate the energy that is used to make products. In ... where they are consumed. A team led by Carnegie,s Steven ...
Cached Biology News:Scripps launches whole genome sequencing study to find root causes of idiopathic diseases 2Scripps launches whole genome sequencing study to find root causes of idiopathic diseases 3Study identifies molecules used by certain species of seaweed to harm corals 2Study identifies molecules used by certain species of seaweed to harm corals 3Study identifies molecules used by certain species of seaweed to harm corals 4Links in the chain: Global carbon emissions and consumption 2
(Date:7/29/2014)... The advanced optical methods and applications for ... a revolution in the neurosciences were the inspiration behind ... SPIE, the international society for optics and photonics ... of the BRAIN Initiative in the United States, and ... vision for and provide examples of the impact that ...
(Date:7/29/2014)... 2014 Human Longevity, Inc. (HLI), a genomics ... extending the healthy, high performance human life span, today ... an expert in machine learning and machine translation as ... from Google where he was Distinguished Research Scientist and ... to HLI Co-Founder and CEO, J. Craig Venter ...
(Date:7/29/2014)... Tough, ultralight foam of atom-thick sheets can be made ... invented at Rice University. , In microscopic images, ... with floors and walls that reinforce each other. The ... and walls of graphene oxide that self-assemble with the ... researchers say the foam could find use in structural ...
(Date:7/29/2014)... 2014  The Society for Clinical Research Sites ... for the 9 th annual Site Solutions ... Amelia Island , Florida.  The focus on collaboration ... however, the topics and format will allow for ... all stakeholders with a continued focus on site ...
Breaking Biology Technology:SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 2SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 3SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 4Franz Och, Ph.D., Expert in Machine Learning and Machine Translation, Joins Human Longevity, Inc. as Chief Data Scientist 2Franz Och, Ph.D., Expert in Machine Learning and Machine Translation, Joins Human Longevity, Inc. as Chief Data Scientist 3Tough foam from tiny sheets 2TransCelerate, Lilly, Pfizer, and FDA Highlight Collaborative Program at the Site Solutions Summit 2TransCelerate, Lilly, Pfizer, and FDA Highlight Collaborative Program at the Site Solutions Summit 3
... 26 Medivation, Inc. (Nasdaq: MDVN) today announced ... Time tomorrow, Tuesday, October 27, to discuss partnering plans for ... testing for the treatment of prostate cancer. , ... call on Tuesday, October 27, at 8:30 a.m. Eastern Time ...
... Champions Biotechnology, Inc. (OTC Bulletin Board: CSBR), ... accelerating the development and enhancing the value of oncology ... Research & Development, a Division of Janssen Pharmaceutica NV, ... in Champions, Biomerk Tumorgraft(TM) platform. , "We ...
... ... presented this week at the annual meeting of the Society for Neuroscience ... a stroke. In prior conferences, data from the University of Wisconsin-Milwaukee ... Quincy Bioscience Quincy Bioscience is a partner in the research ...
Cached Biology Technology:Champions Biotechnology Expands Collaboration to Test Oncology Therapeutic in Biomerk Tumorgrafts(TM) 2Champions Biotechnology Expands Collaboration to Test Oncology Therapeutic in Biomerk Tumorgrafts(TM) 3Jellyfish Protein Extends Neuroprotective Tentacles at Neuroscience Conference 2Jellyfish Protein Extends Neuroprotective Tentacles at Neuroscience Conference 3
... Science FLA-5100 imaging system allows imaging of ... 40 x 46cm at a pixel size ... is especially suitable for protein electrophoresis in ... for genomics., Fuji s FLA-5100 includes four ...
... Biometras T1 Thermocycler provides high speed ... been optimized with a TGradient Thermocycler can ... thermocycler comes with a silver block for ... for 384 well plates or in-situ applications ...
... inL10 Workstation from Caliper represents a revolutionary ... the first time the ability to generate ... to changing conditions. In addition, each ... due to changes in temperature, and offers ...
... Vivaclear centrifugal filters are disposable microfiltration devices ... samples in the range 100 l to 500 ... rotors accepting 2.2 ml centrifuge tubes. Product Features: ... pore size Low hold up volume ...
Biology Products: