( first author of the Nature Medicine stu...)Current human embryonic stem cell lines contaminated UCSD/Salk team finds

first author of the Nature Medicine study is Maria J. Martin, Ph.D., a post doctoral researcher in Varki's lab at UCSD. An important additional author is Gage's post doctoral fellow Alysson Muotri, Ph.D. The study was funded by the National Institute of General Medical Sciences at the National Institutes of Health, the Lookout Fund, and by the G. Harold and Leila Y. Mathers Charitable Foundation of New York. In addition to Varki, authors of the related study in JBC included Muriel Bardor, Ph.D. and Dzung Nguyen, Ph.D., post-doctoral fellows, and Sandra Diaz, a research associate. They determined that Neu5Gc gets into human cells by being engulfed in fluid droplets and then moved to the cytoplasm of the cell by a "pump" called the lysosomal sialic acid transporter. Varki noted that this pathway is an unusual and previously unknown one that may also be relevant to the entry of other small molecules into cells. In addition, the JBC study showed how Neu5Gc attached to dietary proteins from animals could be incorporated into cells lining the stomach and colon, organs where consumption of red meat has been associated with risk of cancer. "Knowing the mechanism that this molecule uses to get into human cells may give us clues to possible solutions to the problems that it may cause in various situations," Varki said.
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Source:Eurekalert


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