Navigation Links
Current human embryonic stem cell lines contaminated UCSD/Salk team finds

Currently available lines of human embryonic stem cells have been contaminated with a non-human molecule that compromises their potential therapeutic use in human subjects, according to research by investigators at the University of California, San Diego (UCSD) School of Medicine and the Salk Institute in La Jolla, California. In a study published online January 23, 2005 in the journal Nature Medicine, the researchers found that human embryonic stem cells, including those currently approved for study under federal funding in the U.S., contain a non-human, cell-surface sialic acid called N-glycolylneuraminic acid (Neu5Gc), even though human cells are genetically unable to make it. In a related paper published November 29, 2004 by the Journal of Biological Chemistry (JBC), the Varki group has also discovered the exact cellular mechanism by which this occurs.

In studies with one of the federally approved human embryonic stem cell lines, the investigators determined that the Neu5Gc is incorporated by the stem cells when they are grown or derived from laboratory cultures that contain animal sources of the non-human Neu5Gc molecule. All traditional culture-dish methods used to grow all human embryonic stem cells include animal-derived materials, including connective tissue cells (so-called "feeder layers") from mice and fetal calf serum. "The human embryonic stem cells remained contaminated by Neu5Gc even when grown in special culture conditions with commercially available serum replacements, apparently because these are also derived from animal products," said both papers' senior author Ajit Varki, M.D., UCSD professor of medicine and cellular & molecular medicine, and co-director of the UCSD Glycobiology Research and Training Center. The research in Nature Medicine was done with human embryonic stem cells grown in the laboratory of Fred Gage, Ph.D., professor, Laboratory of Genetics, the Salk Institute, La Jolla, California, an adjunct professor of neuroscien
'"/>

Source:Eurekalert


Page: 1 2 3 4

Related biology news :

1. Currents could disrupt ocean food chain
2. Novel technology detects human DNA mutations
3. UWs Rosetta software to unlock secrets of many human proteins
4. Genome-wide mouse study yields link to human leukemia
5. Found: Missing sequence of the human Y chromosome
6. Study finds more than one-third of human genome regulated by RNA
7. Molecular machine may lead to new drugs to combat human diseases
8. Sea skate experiment sheds light on human cell transport
9. Mouse brain tumors mimic those in human genetic disorder
10. Zebrafish may hold key to understanding human nerve cell development
11. Yale researchers identify molecule for detecting parasitic infection in humans
Post Your Comments:
(Date:8/17/2015)... 2015  NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... the growing mobile commerce market and creator of the ... Q4 2015. The new marketing campaign is being spearheaded ... Marketing Group ( http://amplitudemarketing.com/ ) and TPMG ( http://tmpg.com/ ... in retail driven marketing and brand awareness and has ...
(Date:8/12/2015)... JOSE, Calif. , Aug. 12, 2015 /PRNewswire/ ... developer of human interface solutions, today announced that ... recently announced Match-in-Sensor solution, have officially been named ... Alliance. As part of the certification, Synaptics, Natural ... FIDO 1.0 Universal Authentication Framework (UAF) standard and ...
(Date:8/6/2015)... , Aug. 6, 2015  Today, U.S. ... visit Crossmatch ™ to learn firsthand how ... protect data. Crossmatch is a world leader in ... and expertise are helping federal agencies and commercial ... security.   "The vast majority of ...
Breaking Biology News(10 mins):NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 2NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 3Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 2Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 3Rep. Honda to Visit Crossmatch in Redwood City 2
... a little genetics in high school has heard of adenine, ... make up the DNA code. But those are not the ... has drawn attention to a fifth nucleotide, 5-methylcytosine (5-mC), that ... regulate which genes are expressed. And now there,s a sixth. ...
... chromosome it,s time X got some attention. ... with being female, University of California, Berkeley, biologist Doris ... the X chromosome is every bit as interesting as ... to the origins and benefits of sexual reproduction. ...
... its kind study examining the effects of methamphetamine use during ... development in children. The research is published in the April ... journal of the American Academy of Neurology. ... age, leading to an increasing number of children with prenatal ...
Cached Biology News:New nucleotide could revolutionize epigenetics 2New nucleotide could revolutionize epigenetics 3New nucleotide could revolutionize epigenetics 4The story of X -- evolution of a sex chromosome 2The story of X -- evolution of a sex chromosome 3The story of X -- evolution of a sex chromosome 4Prenatal meth exposure linked to abnormal brain development 2
(Date:8/26/2015)... WARREN, N.J. , Aug. 26, 2015  Roka ... company focused on providing advanced testing solutions for the ... Thomas, CEO will present at the Sidoti & Company ... The conference will be held at the New York ... the presentation will be available through the investor relations ...
(Date:8/26/2015)... FRANCISCO , Aug. 26, 2015  Platform ... that it has received a $1.5M Phase II ... (NIH) to further develop its therapeutic agent to ... clinical need in end stage renal disease (ESRD) ... the National Institute of Diabetes and Digestive and ...
(Date:8/26/2015)... HONG KONG , Aug. 26, 2015 ... "Company"), China,s leading provider of ... and stem cell storage services, today announced that the ... Holdings Limited ("MO2"), an entity wholly owned by Mr. ... the Company, has acquired the outstanding shares (the "Shares") ...
(Date:8/26/2015)... ... ... PRC Clinical, a Clinical Trial Management Expert CRO, will be ... California. The Clinical Trial Management Expert CRO seeks to introduce more California-based sponsors to ... , Stem Cell Meeting on the Mesa on October 7-9 in ...
Breaking Biology Technology:Symic Biomedical Awarded $1.5MM NIH Phase II SBIR Grant to Develop its Proteoglycan Mimetic Therapeutics to Reduce Vascular Access Failures in ESRD 2Symic Biomedical Awarded $1.5MM NIH Phase II SBIR Grant to Develop its Proteoglycan Mimetic Therapeutics to Reduce Vascular Access Failures in ESRD 3China Cord Blood Corporation Receives Notice of Transactions Regarding its 7% Senior Convertible Notes Due 2017 2China Cord Blood Corporation Receives Notice of Transactions Regarding its 7% Senior Convertible Notes Due 2017 3PRC Clinical To Attend Major Industry Conferences And Meet Sponsor Companies In The San Diego Biotech Hub 2PRC Clinical To Attend Major Industry Conferences And Meet Sponsor Companies In The San Diego Biotech Hub 3
... has announced that the southwestern laboratory network TriCore ... Virus genotyping reagents. , ,The reagents are part of tests ... virus, a blood-transmitted disease estimated to be chronic in 4 ... do not know it, according to Third Wave's company statement. ...
... Every year around Labor Day, a slew of surveys and ... worker. One released by the Associated Press earlier this week ... percent) and think their pay is fair (71 percenet). But ... ,In the spirit of the presidential election season, I thought ...
... James Thomson, pictured here in 2001 in his Primate Center ... of Wisconsin anatomy professor James Thomson attempted to ... of stem cell research, which in some cases uses tissue ... to about 200 at the UW Memorial Union as part ...
Cached Biology Technology:Are your working conditions better now or worse? 2Are your working conditions better now or worse? 3UW stem cell guru outlines scientific and political future 2UW stem cell guru outlines scientific and political future 3
... RQ1 RNase-Free DNase is a ... single-stranded or double-stranded DNA to produce ... for use in applications where maintaining ... RQ1 DNase is qualified for use ...
... catalyzes the template-directed polymerization of nucleotides into ... Polymerase I possesses a 3?5 exonuclease activity ... rate during DNA replication, and also contains ... enzyme to replace nucleotides in the growing ...
RNase-Free DNase 50 l...
DNA polymerase I, large fragment...
Biology Products: