Navigation Links
Critical role in programmed cell death identified

Dartmouth Medical School geneticists have found links in the cell death machinery of worms and mammals, opening new avenues for studying and targeting a process vital to development and implicated in cancer and autoimmune diseases.

The work, reported in the February 17 issue of Nature, demonstrates the role of mitochondria, the cellular power plant, in prompting worm cells to self destruct. These results unify cell death models along the evolutionary spectrum, from simple animal systems to humans.

In spite of its name, programmed cell death, or apoptosis, is essential for life; it's needed for nervous system development and it keeps the body up and running. Miscues and failures are instrumental in cancer, autoimmune disorders or neurodegenerative diseases.

Mitochondria, the organelles responsible for producing energy to fuel cell processes, also appear to release molecules that set the cell death program in motion. While their activity in mammalian cell death was known, mitochondrial involvement in worms had not previously been shown.

The new work, led by Dr. Barbara Conradt, assistant professor of genetics at Dartmouth Medical School, reveals the importance of mitochondria in cell death in the roundworm C. elegans, enhancing the view of how cell death is conserved from worms to humans.

"Now it seems that there is really one way of killing cells and it involves these mitochondria. Using genetics, we could rigorously show that mitochondria are part of it. It unifies two different hypothesis and makes worms a great model to analyze how cell death is induced, " Conradt said.

Mitochondria are dynamic structures, constantly changing shape, budding and fusing. In cells instructed to die, the mitochondria tend to become smaller or fragment, but whether this fragmentation is a requirement for cell death or a byproduct has been unclear, until now.

Conradt and her colleagues determined that mitochondrial fragmentation is
'"/>

Source:Dartmouth Medical School


Page: 1 2 3

Related biology news :

1. White Blood Cell Waste Disposal System Plays Critical Regulatory Role
2. Critical step traced in anthrax infection
3. Critical hearing gene helps send auditory messages to brain
4. Its not fair! We are programmed to resist weight loss
5. Researchers unveil strategy for creating actively-programmed anti-cancer molecules
6. Heart failure: Intervention possibilities from imaging programmed cell loss
7. Combination therapy boosts effectiveness of telomere-directed cancer cell death
8. Enzyme allows B cells to resist death, leading to leukemia
9. A comprehensive response to HIV could prevent 10 million AIDS deaths in Africa by 2020
10. The death of a very special chimpanzee
11. The very unexpected life and death of a leukemic cell
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Critical role programmed cell death identified

(Date:7/22/2014)... purified crystals that split light with uncanny precision ... and, potentially, computers that manipulate light instead of ... such as etching them with a precise beam ... , Now, researchers at Princeton and Columbia universities ... scientists to customize and grow these specialized materials, ...
(Date:7/22/2014)... milk helps make their bones strong or that fish is food ... if something is good for us, it must surely taste bad? ... Research , when children hear about the benefits of healthy food, ... food is presented to children as making them strong or as ... read or count, they would conclude the food is not as ...
(Date:7/22/2014)... trees and not just asphalt and recreation equipment reduces ... Colorado Boulder study. , Working on class assignments or ... youth, according to a paper published in the journal ... of the first of its kind to focus on ... stress. , "Many schools already offer stress management programs, ...
Breaking Biology News(10 mins):Technique simplifies the creation of high-tech crystals 2Technique simplifies the creation of high-tech crystals 3Natural-terrain schoolyards reduce children's stress, says Colorado University-Boulder study 2Natural-terrain schoolyards reduce children's stress, says Colorado University-Boulder study 3
... of Medicine (BUSM) have demonstrated that certain T cells ... pro-inflammatory response in people with type 2 diabetes (T2D). ... a loss in homeostasis in this group of T ... Barbara Nikolajczyk, PhD, an associate professor of ...
... the winners of its international travel grants to ... the Baltimore Convention Center in Baltimore, Maryland, March ... is to foster and initiate further interaction between ... financial difficulties. Recipients of this competitive award ...
... rap as vermin and pests because they seem to thrive ... in Africa for the past 50 million years. From ... a stable and plentiful source of food, says paleontologist Alisa ... fossils are proving their usefulness to scientists as they help ...
Cached Biology News:Biophysical Society announces winners of 2011 International Travel Awards 2Biophysical Society announces winners of 2011 International Travel Awards 3Biophysical Society announces winners of 2011 International Travel Awards 4Rodents were diverse and abundant in prehistoric Africa when our human ancestors evolved 2Rodents were diverse and abundant in prehistoric Africa when our human ancestors evolved 3
(Date:7/22/2014)... Parsippany, NJ (PRWEB) July 22, 2014 ... analytical, precision, portable, and mechanical balances and scales, ... precision balances has won Laboratory Equipment magazine’s 2014 ... is the second consecutive year the Explorer was ... readers. The annual Readers’ Choice Awards celebrates “excellence ...
(Date:7/22/2014)... and SHENZHEN, China , ... Co., LTD, (BGI Tech), a subsidiary of BGI, ... global launch of a new human whole exome ... This newly offered service includes in-depth bioinformatics analysis ... prices until December 31, 2014. ...
(Date:7/22/2014)... (PRWEB) July 22, 2014 Quorum Review IRB, ... service for large clinical trials called Quick Step™ . ... designed to address the research industry’s need for seamless study ... service is available for studies planning 50 or more North ... combined planned North American site count of 80 or more. ...
(Date:7/22/2014)... 2014 The next session of ... and will comprise of the increasingly popular ‘Base SAS’ ... is a series of technical hands-on classes for entry-level ... reach the next step in their professional careers. , ... by Jennifer Kang, Senior Statistician at Genentech and former ...
Breaking Biology Technology:OHAUS Explorer Voted “Best Balance” in Laboratory Equipment’s 2014 Readers’ Choice Awards 2BGI Tech Launches Human Whole Exome Sequencing Service on Complete Genomics' Advanced Platform 2BGI Tech Launches Human Whole Exome Sequencing Service on Complete Genomics' Advanced Platform 3Quorum Review IRB Launches New Quick Step™ Service for Large Clinical Trials 2Quorum Review IRB Launches New Quick Step™ Service for Large Clinical Trials 3Clinovo TechTrainings: Next Session of SAS and CDISC Classes Start 9th September, 2014 2Clinovo TechTrainings: Next Session of SAS and CDISC Classes Start 9th September, 2014 3
... March 21, 2011 Cell Therapeutics, Inc. ("CTI") (Nasdaq ... its randomized pivotal trial of pixantrone for the treatment ... trial is now open to patient enrollment. The trial, ... will compare a combination of pixantrone plus rituximab to ...
... 18, 2011 Driving value for customers is critical to ... points between a customer and an organization, there has to ... an organization to succeed in the marketplace. ... Practices, LLC., noted in this month,s special issue of PharmaVoice ...
... 2011 BioMarin Pharmaceutical Inc. (Nasdaq: BMRN ... Approach for PKU Treatment) in an abstract (Abstract #91 ... presented by Barbara Burton, MD at the 2011 annual ... Canada.  ADAPT, which was funded by a grant from ...
Cached Biology Technology:Cell Therapeutics Initiates Pixantrone PIX-R Pivotal Trial for Treatment of Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma 2Cell Therapeutics Initiates Pixantrone PIX-R Pivotal Trial for Treatment of Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma 3Cell Therapeutics Initiates Pixantrone PIX-R Pivotal Trial for Treatment of Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma 4Best Practices, LLC Showcases Its Expertise in Customer Relationship Management 2First-of-Its-Kind Study Suggests Importance of Routine Mental Health Screening in the Care of Patients Suffering From Genetic Disease PKU 2First-of-Its-Kind Study Suggests Importance of Routine Mental Health Screening in the Care of Patients Suffering From Genetic Disease PKU 3First-of-Its-Kind Study Suggests Importance of Routine Mental Health Screening in the Care of Patients Suffering From Genetic Disease PKU 4First-of-Its-Kind Study Suggests Importance of Routine Mental Health Screening in the Care of Patients Suffering From Genetic Disease PKU 5First-of-Its-Kind Study Suggests Importance of Routine Mental Health Screening in the Care of Patients Suffering From Genetic Disease PKU 6First-of-Its-Kind Study Suggests Importance of Routine Mental Health Screening in the Care of Patients Suffering From Genetic Disease PKU 7First-of-Its-Kind Study Suggests Importance of Routine Mental Health Screening in the Care of Patients Suffering From Genetic Disease PKU 8