Navigation Links
Critical hearing gene helps send auditory messages to brain

that influx of calcium leads small "sacs" full of neurotransmitter to fuse with the cell membrane, releasing their contents into the space, or synapse, between the sensory cells and auditory nerve endings.

That chemical release allows nerve messages to be passed from one neuron to another. In inner hair cells, those neurotransmitter-filled vesicles are held in place at the cell membrane by tethers known as "ribbons."

The current study follows up a report by Petit's team several years ago that people with a recessive form of deafness harbor two abnormal copies of the otoferlin gene. They also had some evidence hinting that the gene might act as a calcium sensor with an important role in neurotransmitter release by the inner hair cells. For example, otoferlin resembles a calcium-sensing protein involved in release of chemicals by sensory neurons elsewhere in the body. Their current study provides additional evidence to confirm that notion.

They now report that otoferlin activity in the cochlea occurs only in the inner hair cells, where it concentrates in the ribbon-associated synaptic vesicles. They also found that the otoferlin protein binds calcium and interacts with other proteins known to play a role in neurotransmitter release.

To further examine the gene's role in a living animal, the researchers studied "knockout" mice completely lacking a functional otoferlin gene. When exposed to sounds of various frequencies, the mice showed no detectable activity in parts of the brain that normally process sound.

They further found that the profoundly deaf mice suffered a complete loss of neurotransmitter release from their inner hair cells, despite having an apparently normal "ribbon synapse" and calcium flow.

The findings led the researchers to conclude that "otoferlin is essential for a late step of [neurotransmitter release] and may act as the major [calcium] sensor triggering membrane fusion at the inner hair cell
'"/>

Source:Cell Press


Page: 1 2 3

Related biology news :

1. Critical role in programmed cell death identified
2. White Blood Cell Waste Disposal System Plays Critical Regulatory Role
3. Critical step traced in anthrax infection
4. Frog’s ear canal may provide insights for understanding human hearing loss
5. Yale researchers find environmental toxins disruptive to hearing in mammals
6. Nicotine exposure during development leads to hearing problems
7. Female birds boost up their eggs when hearing sexy song
8. St. Jude finds clues to hearing loss from chemotherapy
9. To elude bats, a moth keeps its hearing in tune
10. Stem cell transplants explored at Stanford as a possible treatment for hearing loss
11. Study shows isolation of stem cells may lead to a treatment for hearing loss
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Critical hearing gene helps send auditory messages brain

(Date:7/25/2014)... factor characterized by the existence of numerous isoforms ... to the protein deeply different characteristics. NRG1 plays ... during development and the different phases occurring after ... regrowth, remyelination and target reinnervation, Researchers at the ... soluble NRG1 upregulation observed in Schwann cells immediately ...
(Date:7/25/2014)... tractography (DTT), which is derived from diffusion tensor ... motor tracts, such as the corticospinal tract, the ... The corticospinal tract is known to be a ... human brain. Several studies have reported on injury ... addition, some studies have demonstrated recovery of a ...
(Date:7/25/2014)... MOResearchers at the Stowers Institute for Medical Research ... pheromone receptors, and found pheromones crucial to triggering the ... of receptors helps a male mouse detect pheromones that ... of receptors lets him know if the female mouse ... pheromones are critical to trigger mating. Stowers, researchers believe ...
Breaking Biology News(10 mins):It takes two to court 2It takes two to court 3
... technologies are repairing the human body in ways never ... leaving an increasing population of patients who are newly ... have become a formidable clinical opponent, and foremost among ... a new text from ASM Press. "This ...
... This Christmas season, think twice about spending money on ... good, old-fashioned methodkeeping your tree in a container of ... tree green and healthy. Researchers have determined that some ... fact, in several cases the chemical retardants sped up ...
... In light of recent developments that threaten to lead to ... daily satellite images of the ice shelf available to the ... to monitor the developments as they occur. The Wilkins ... coast of the Antarctic Peninsula, has undergone many changes in ...
Cached Biology News:New text focuses on formidable opportunistic fungus 2Flame retardants prove ineffective on fresh-cut Christmas trees 2
(Date:7/25/2014)... 25, 2014 Sinovac Biotech Ltd. (Nasdaq: ... China , today announced that it will release ... 30, 2014, after market close on Thursday, August 14, 2014 ... the market opening on Friday, August 15, 2014, at 8:00 ... Standard Time) to review the Company,s financial results and provide ...
(Date:7/24/2014)... , July 24, 2014  Now available is a ... Rehealth Regenerative Therapies , located in ... physically active people a new health option: stem ... of age, countless patients suffer from joint and muscle ... as muscle tears, torn rotator cuff, tennis elbow, and ...
(Date:7/24/2014)... leader Yung-Eun Sung has announced that they have ... graphenes which can be applied as high performance ... Sung is both a group leader at the ... Science* (IBS) and a professor at the Seoul ... with regards to the development of relative simplicity, ...
(Date:7/24/2014)... Research and Markets has announced the addition ... report to their offering.  http://photos.prnewswire.com/prnh/20130307/600769 ... vitro growth of plant or animal cells for several ... Cell culture is a crucial step in tissue engineering ... consumables are necessary for the in vitro production of ...
Breaking Biology Technology:Sinovac to Host Conference Call to Report Second Quarter 2014 Unaudited Financial Results 2Stem Cells In Sports Injuries, Joints And Muscular Pain 2Stem Cells In Sports Injuries, Joints And Muscular Pain 3Global Cell Culture Market 2014-2018: Key Vendors are Becton, Dickinson and Co, EMD, GE Healthcare, Lonza Group, Sigma Aldrich and Thermo Fisher Scientific 2
... is a missing link in the capital food chain, and Bill ... devoured by it. , ,Payne, an entrepreneur-in-residence for the Kauffman ... to address the June 25 Wisconsin Alumni Research Foundation's ... the capital food chain for entrepreneurs, and he's familiar with all ...
... have pleaded guilty in Milwaukee to charges of criminal ... $6 million in counterfeit Rockwell Automation computer ... Alice Fisher for the Criminal Division and U.S. Attorney ... announced that Robert Koster of Jonesboro, Ark. pleaded ...
... print still captures the imagination of consumers - even consumers ... clearer example than Blurb . I first discussed Blurb ... than a brief PowerPoint deck. We met at ... unwound a vision for consumer-generated books that well pre-dates the ...
Cached Biology Technology:Investor warns of angel-venture funding gap 2Investor warns of angel-venture funding gap 3Two convicted of selling $6 million in counterfeit Rockwell software on eBay 2Blurb shows that print still captures imaginations 2Blurb shows that print still captures imaginations 3
Mouse monoclonal antibody raised against a partial recombinant AATK. NCBI Entrez Gene ID = AATK...
... The Rotofor purification system with PowerPac 3000 ... protein separation and purification by liquid-phase isoelectric ... mini (18 ml) and standard (60 ml) ... electrode chambers, PowerPac 3000 power supply, 10 ...
... Bio-Rad Molecular Imager VersaDoc MP 4000 ... CCD based imaging system capable of ... methods, including fluorescence, chemiluminescence, densitometry, and ... illumination sources allow imaging of multiplexed ...
...
Biology Products: