Navigation Links
Critical hearing gene helps send auditory messages to brain

By studying a gene earlier linked to deafness in humans, researchers now have new insight into the molecular process by which components of the inner ear send messages to the brain. The team reports its findings in the October 20, 2006, issue of the journal Cell, published by Cell Press.

The researchers found that mice lacking the gene otoferlin are profoundly deaf. The animals' deafness results from an inability to translate sound stimulation into the release of a chemical nerve messenger, or neurotransmitter, that would usually pass that information to auditory nerves and on to the brain, they reported. The sensory structures within the mutant animals' ears otherwise appeared to develop normally.

"Study of the genes responsible for deafness can bring new insight into the molecular basis of how hearing works," said Christine Petit of the Institut Pasteur in Paris, France.

The sensory machinery within the inner ear is particularly intriguing, she added, "in the sense that it operates with extreme temporal precision."

In mammals, the hearing organ, or cochlea, is a snail-shaped structure of the inner ear that is filled with a watery fluid. When that liquid moves in response to sound vibrations, thousands of sensory "hair" cells are set into motion.

Those sensory receptors come in two types: inner and outer hair cells. Outer hair cells amplify sound within the cochlea, allowing for hearing sensitivity. In contrast, inner hair cells are "the genuine sensory cells transmitting information on the temporal structure and intensity of sound to the central nervous system," Petit said.

While outer hair cell defects can lead to considerable hearing loss, she added, a loss of inner hair cell function results in total deafness as messages cannot get through.

Inner hair cells operate in a manner comparable to neurons, she said. When an inner hair cell is stimulated, channels open up allowing calcium to flow in. In turn,
'"/>

Source:Cell Press


Page: 1 2 3

Related biology news :

1. Critical role in programmed cell death identified
2. White Blood Cell Waste Disposal System Plays Critical Regulatory Role
3. Critical step traced in anthrax infection
4. Frog’s ear canal may provide insights for understanding human hearing loss
5. Yale researchers find environmental toxins disruptive to hearing in mammals
6. Nicotine exposure during development leads to hearing problems
7. Female birds boost up their eggs when hearing sexy song
8. St. Jude finds clues to hearing loss from chemotherapy
9. To elude bats, a moth keeps its hearing in tune
10. Stem cell transplants explored at Stanford as a possible treatment for hearing loss
11. Study shows isolation of stem cells may lead to a treatment for hearing loss
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Critical hearing gene helps send auditory messages brain

(Date:7/31/2014)... (almonds, Brazil nuts, cashews, hazelnuts, macadamias, pecans, pine nuts, ... publications, British Medical Journal Open (BMJ Open) ... BMJ Open article looked at the effects of ... that tree nut consumption resulted in a significant decrease ... ONE article focused on the effect of tree ...
(Date:7/30/2014)... regulate its genes, and adapt to changes in its ... regulation taking place in the truffle, is published in ... illustrates how the truffle deals with its complex genome,s ... may shed light on how traits like aroma and ... known as Prigord truffles, have a syrupy sweet flavor ...
(Date:7/30/2014)... until they hatched 4.5 years later, according to a ... PLOS ONE by Bruce Robison from Monterey ... have a single reproductive period during their life, where ... eggs until they hatch. Shallow-water octopuses typically care for ... is known about the brooding of deep-sea species. Using ...
Breaking Biology News(10 mins):New international tree nut council study looks at nuts, diabetes and metabolic syndrome 2How black truffles deal with the jumpers in their genome 2Deep-sea octopus has longest-known egg-brooding period 2
... nanotechnology fanciers suggest that, like proverbial birds of ... or clump together. This tendency, they ... manufacturing increases and the number of nanotechnology-enabled products ... Maynard, chief science advisor to the Project on ...
... completing the first large-scale report sequencing breast and colon ... studied the vast majority of protein-coding genes which now ... mutated in relatively few cancers. Their report, published ... indicates that while little is known about these less-commonly ...
... a reality today, but how can we find out about ... a full record of the Earths climate for several hundred ... that can be taken to the lab for analysis. Incredibly, ... Antarctic regions, and a European Science Foundation programme has a ...
Cached Biology News:Nanoparticle exposures happen, says expert 2Genome update defines landscape of breast and colon cancers 2Genome update defines landscape of breast and colon cancers 3European lead in reading past climates from ice cores 2European lead in reading past climates from ice cores 3
(Date:7/31/2014)... Indiana University Bloomington have described the self-assembly of ... with potential value for the field of organic ... cells. , Their paper, "Anion-Induced Dimerization of 5-fold ... Self-Assembled Crystals," has been published online by ... Society of Chemistry. It is the first collaboration ...
(Date:7/31/2014)... , July 31, 2014 According ... Research "Quantum Dots Market - Global Industry Analysis, Size, ... market was valued at USD 88.5 million in 2011, ... 2023, growing at a CAGR of 53.8% from 2013 ... Market Report at  http://www.transparencymarketresearch.com/quantum-dots.html Increasing demand ...
(Date:7/31/2014)... NY (PRWEB) July 31, 2014 Graphite ... in high temperature oven carts. These bearings are uniquely ... in sealed ball bearings because of the high ... alumina requested help from the design engineers at Graphite ... a heating process. During their manufacturing operation, pans containing ...
(Date:7/31/2014)... York , July 31, 2014 ... Transparency Market Research "Electrodes for Medical Devices Market (Diagnostic ... Electrodes, Therapeutic Electrodes - TENS, Pacemakers, Defibrillators, Electrosurgical and ... Trends and Forecast, 2013 - 2019," the global electrodes ... million in 2012 and is estimated to reach a ...
Breaking Biology Technology:Chemists demonstrate 'bricks-and-mortar' assembly of new molecular structures 2Chemists demonstrate 'bricks-and-mortar' assembly of new molecular structures 3Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 2Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 3Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 4Graphite Metallizing Announces Bearings for High Temperature Oven Applications 2Graphite Metallizing Announces Bearings for High Temperature Oven Applications 3Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 2Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 3Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 4Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 5Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 6
... J. Samskog, H. Wadensten, and J. Flensburg ... Sweden , , ... analyse phosphopeptides in mouse brain tissue. The trypsin-digested tissue was separated ... using Ettan MDLC. The detection was performed by mass spectrometry using ...
... Key words: SPA Imaging Beads ... , SPA Imaging Assays ... an SPA Imaging Bead in order to generate a signal. Polystyrene (PS) ... rabbit secondary antibodies during the assay. The Donkey Anti-Rabbit PS SPA Imaging ...
... , ... Imaging Beads , ... (CGRP) is believed to have an important physiological role in the central ... basilar arteries, in vitro studies have identified a number of ...
Cached Biology Technology:Sensitive identification of phosphopeptides in brain tissue using Ettan MDLC and Finnigan LTQ 2Sensitive identification of phosphopeptides in brain tissue using Ettan MDLC and Finnigan LTQ 3Sensitive identification of phosphopeptides in brain tissue using Ettan MDLC and Finnigan LTQ 4Utilization of Donkey Anti-Rabbit PS SPA Imaging Beads in the quantitative measurement of cAMP in cells 2Utilization of Donkey Anti-Rabbit PS SPA Imaging Beads in the quantitative measurement of cAMP in cells 3Utilization of Donkey Anti-Rabbit PS SPA Imaging Beads in the quantitative measurement of cAMP in cells 4The development of a calcitonin-gene related peptide (CGRP) receptor-binding assay using the LEADseeker Multimodality Imaging System 2The development of a calcitonin-gene related peptide (CGRP) receptor-binding assay using the LEADseeker Multimodality Imaging System 3The development of a calcitonin-gene related peptide (CGRP) receptor-binding assay using the LEADseeker Multimodality Imaging System 4The development of a calcitonin-gene related peptide (CGRP) receptor-binding assay using the LEADseeker Multimodality Imaging System 5
HRP Monoclonal-Goat Diluent - 5X Concentrate, 25 mL...
Rabbit anti-Junctophilin-4 (C-term)...
... CopyControl™ PCR Cloning Kits are designed to speed ... that all PCR products, regardless of sequence or ... PCR products including those that are difficult to ... may be unstable or code for potentially detrimental ...
Size & Applications: 20 ml Storage Temp.: -20C Shelf Life: 12 months ...
Biology Products: