Navigation Links
Creating new life forms that may help eradicate cancer affecting women

Instead of using the usual cancer-fighting modalities, surgery, chemotherapy, or radiation, researchers from a drug development company called Advaxis, have embarked on a novel approach to fighting cancer: Engaging the immune system to attack cancer in the same the way it would a flu vaccine, by creating new life forms.

Dr. Vafa Shahabi, Advaxis' Director of Research and Development, reports that because the human immune system is not designed to fight cancer on its own, she and her colleagues are trying to harness its power through a new kind of life form: specifically a family of vaccines, which they call Lovaxin. The vaccines are comprised of new strains of bacteria created in Advaxis' laboratory that are programmed to kill off specific cancers.

The Key: A Microbe Found in Dairy Products

Central to this startling discovery is the microbe Listeria monocytogenes, a common bacterium found in milk, cheese and other dairy products. This microorganism apparently aids in fighting cancer by activating the body's own killer (cytotoxic T) cells to elicit a stronger than normal immune response to the presence of cancer cells. The vaccines "teach" the immune system to mount a specialized, targeted response that is lethal to cancer.

When Listeria is introduced in the body, it has a powerful, direct stimulatory effect on the activities of tumor-killing T cells. "Essentially the modified Listeria vaccines harness the power of the immune system against this infectious agent," explains Dr. Shabahi, "and then directs it to successfully attack cancer cells. The bacterium in effect then becomes a cancer-fighting 'Trojan horse,' with the enemy tucked inside."

For breast cancer, Dr. Shababi's team fused Listeria with a tumor-associated protein, HER-2/Neu, to immune cells, to create a vaccine called Lovaxin B. What these cells do is enlist killer T cells to seek and destroy tumor cells that over-express the HER-2/Neu molecule. This is significant because HER-2/Neu is over- expressed in 20%- 40% of all breast cancers.

As Dr. Shababi explains: "We not only created a new breast cancer vaccine, but also have a new life form, since the modified Listeria becomes a new strain, not seen in nature. In effect, it becomes a cancer fighting "superbug" capable of treating breast cancer in patients whose tumors express the HER-X/Neu protein." Advaxis has already created several strains for potential use in future vaccines to treat other cancers. The company is also currently testing its cervical cancer vaccine, Lovaxin C, in phase I/II trials.


'"/>

Source:Advaxis, Inc.


Related biology news :

1. Creating a window on oceans in motion
2. Products containing specific probes for detecting alternative splice forms protected
3. IBM Transforms the Art of Scientific Expeditions
4. MIT researcher presents new view of how the cortex forms
5. Carnegie Mellon U. transforms DNA microarrays with standard Internet communications tool
6. New study explores beetle species with two forms of females
7. How the octopus forms an elbow
8. AIDS-related cognitive impairment exists in two separate forms
9. Scientists discover new life forms in the Arctic Ocean
10. Genetic pathways to curable and incurable forms of pancreatic cancer identified
11. Breast tumors in mice eradicated using cancer vaccine
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/29/2017)... , March 29, 2017  higi, the health ... in North America , today announced ... and the acquisition of EveryMove. The new investment and ... set of tools to transform population health activities through ... lifestyle data. higi collects and secures data ...
(Date:3/24/2017)... DUBLIN , Mar 24, 2017 Research ... Vehicle Access System Market Analysis & Trends - Industry Forecast to ... ... poised to grow at a CAGR of around 15.1% over the ... This industry report analyzes the market estimates and forecasts for ...
(Date:3/22/2017)... YORK , March 21, 2017 ... Marketing Cloud used by retailers such as 1-800-Flowers ... its platform — Product Recommendations and Replenishment. Using Optimove,s ... give more personalized product and replenishment recommendations to ... but also on predictions of customer intent drawn ...
Breaking Biology News(10 mins):
(Date:4/26/2017)... , April 26, 2017  Genisphere LLC, ... platform, has signed a collaborative and sponsored research ... Silvia Muro . The overall goal of ... pharmacodynamics of various 3DNA designs and formulations after ... targeting diseases of the vasculature as well as ...
(Date:4/25/2017)... Diego, CA (PRWEB) , ... April 25, 2017 ... ... division of L3 Healthcare, is pleased to announce the company is now a ... management. The iMedNet software certification enables the company’s clinical research team to ...
(Date:4/25/2017)... (PRWEB) , ... April 25, 2017 , ... ... Services and Metrology Partners.     , Covalent’s Analytical Services unit provides high-quality ... can be measured within 24 hours of receipt. There are no price premiums, ...
(Date:4/24/2017)... -- Dante Labs announced today the offer of whole genome sequencing ... American individuals have been able to access WGS at $1,000, ... below EUR 1,000. The sequencing includes bioinformatics analysis ... make informed decisions about disease monitoring, prevention, nutrition, exercise, health ... ...
Breaking Biology Technology: