Navigation Links
Creating new life forms that may help eradicate cancer affecting women

Instead of using the usual cancer-fighting modalities, surgery, chemotherapy, or radiation, researchers from a drug development company called Advaxis, have embarked on a novel approach to fighting cancer: Engaging the immune system to attack cancer in the same the way it would a flu vaccine, by creating new life forms.

Dr. Vafa Shahabi, Advaxis' Director of Research and Development, reports that because the human immune system is not designed to fight cancer on its own, she and her colleagues are trying to harness its power through a new kind of life form: specifically a family of vaccines, which they call Lovaxin. The vaccines are comprised of new strains of bacteria created in Advaxis' laboratory that are programmed to kill off specific cancers.

The Key: A Microbe Found in Dairy Products

Central to this startling discovery is the microbe Listeria monocytogenes, a common bacterium found in milk, cheese and other dairy products. This microorganism apparently aids in fighting cancer by activating the body's own killer (cytotoxic T) cells to elicit a stronger than normal immune response to the presence of cancer cells. The vaccines "teach" the immune system to mount a specialized, targeted response that is lethal to cancer.

When Listeria is introduced in the body, it has a powerful, direct stimulatory effect on the activities of tumor-killing T cells. "Essentially the modified Listeria vaccines harness the power of the immune system against this infectious agent," explains Dr. Shabahi, "and then directs it to successfully attack cancer cells. The bacterium in effect then becomes a cancer-fighting 'Trojan horse,' with the enemy tucked inside."

For breast cancer, Dr. Shababi's team fused Listeria with a tumor-associated protein, HER-2/Neu, to immune cells, to create a vaccine called Lovaxin B. What these cells do is enlist killer T cells to seek and destroy tumor cells that over-express the HER-2/Neu molecule. This is significant because HER-2/Neu is over- expressed in 20%- 40% of all breast cancers.

As Dr. Shababi explains: "We not only created a new breast cancer vaccine, but also have a new life form, since the modified Listeria becomes a new strain, not seen in nature. In effect, it becomes a cancer fighting "superbug" capable of treating breast cancer in patients whose tumors express the HER-X/Neu protein." Advaxis has already created several strains for potential use in future vaccines to treat other cancers. The company is also currently testing its cervical cancer vaccine, Lovaxin C, in phase I/II trials.


'"/>

Source:Advaxis, Inc.


Related biology news :

1. Creating a window on oceans in motion
2. Products containing specific probes for detecting alternative splice forms protected
3. IBM Transforms the Art of Scientific Expeditions
4. MIT researcher presents new view of how the cortex forms
5. Carnegie Mellon U. transforms DNA microarrays with standard Internet communications tool
6. New study explores beetle species with two forms of females
7. How the octopus forms an elbow
8. AIDS-related cognitive impairment exists in two separate forms
9. Scientists discover new life forms in the Arctic Ocean
10. Genetic pathways to curable and incurable forms of pancreatic cancer identified
11. Breast tumors in mice eradicated using cancer vaccine
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/2/2016)...   Parabon NanoLabs (Parabon) announced today ... Office and the Defense Forensics and Biometrics Agency ... company,s Snapshot Kinship Inference software for ... defense-related DNA forensics.  Although Snapshot is best known ... ancestry from DNA evidence), it also has the ...
(Date:2/1/2016)... Fla. , Feb. 1, 2016  Wocket® smart wallet ( www.wocketwallet.com ... and television personality, Joey Fatone . Las Vegas ... greet fans. --> Las Vegas , where ... --> The new video ad was filmed at the Consumer ... appeared at the Wocket booth to meet and greet fans. ...
(Date:1/25/2016)... 2016  Glencoe Software, the world-leading supplier of image ... will provide the data management solution OMERO Plus for ... Photo - ... Phenotypic analysis measures the characteristics and behavior ... between states such as health and disease, the presence ...
Breaking Biology News(10 mins):
(Date:2/8/2016)... , Feb. 8, 2016 Novan, Inc. today announced ... of the Board of Directors of Novan. In addition, Robert ... North Carolina . --> ... also announced that it received a total of $32.8 million of ... from its private investor network originating throughout the Research Triangle area ...
(Date:2/8/2016)... ... February 08, 2016 , ... Franz Inc. ... Graph Database technology, today announced the availability of AllegroGraph 6, the leading Semantic ... Cloudera Certified Technology Program (CCPT). AllegroGraph is the first Semantic Graph ...
(Date:2/6/2016)... ... ... The Center for Excellence in Education (CEE) will sponsor a Bite of ... 10, 2016. This Bite of Science session, hosted by the Smithsonian-Mason School of ... Road in Front Royal, VA from 5:00 p.m. to 8:00 p.m. The dinner is ...
(Date:2/5/2016)... , February 5, 2016 Amarantus ... biotechnology company focused on developing products for Regenerative Medicine, ... Rare Pediatric Disease Designation (RPDD) from the US Food ... with MANF. MANF was previously granted orphan drug designation ... --> Amarantus BioScience Holdings, Inc. (OTCQB: ...
Breaking Biology Technology: