Navigation Links
Cracking the genetic code for control of gene expression

Molecular biologists, developmental biologists and computer scientists at the Universtity of Helsinki, Finland, came together to advance towards cracking the code for how gene expression is controlled. The results of this work are published in Cell, in January 2006.

A genome milestone was reached in 2001 when sequencing of the human genome was completed. This has been followed by complete chemical read-outs of DNA sequence for several species, for example mouse, dog, cow and chicken, in the recent years. But without a code or 'grammar' to reveal the message behind the sequence, the genomic DNA is merely a list of millions and millions of base pairs, A's, C's, G's and T's one after the other.

Based on the universal code by which DNA encodes amino acids, we can make sense of the constantly increasing amout of DNA sequence data as far as it encodes proteins. This code was solved in 1966 and it has allowed researchers to find new genes and estimate the total number of genes in the human genome. However, coding sequence covers only about 1.2% of the human genome. New codes and grammatical rules need to be resolved in order to understand the remaining 98.8% of the genome.

It is evident that genes are expressed in tightly controlled spatial and temporal patterns but we do not know the code by which the expression is regulated. In this post-genomic era, the next big goal is to decipher the genetic code of regulation of gene expression.

At the University of Helsinki the researchers have been interested in sequences which regulate gene expression. The research group, led by professor Jussi Taipale, Ph.D, has defined the binding specificities of several transcription factors. Transcription factors are DNA-binding proteins which are required to activate gene expression. In collaboration biologists and computer scientists designed a software called EEL (enhancer element locator) which searches genomic sequence for regions where many transcription factors bind DNA side by side. Finding the same region with high frequency of transcription factors in several species indicates that the DNA element regulates gene expression. The researchers showed that the predicted regulatory elements direct organ-specific expression of a marker gene in transgenic mice. Novel experimental and computational methods enabled genome-wide analysis of regulatory elements in several species.

Studying the control of gene expression is a growing area of research at the moment, likely owing to its fundamental importance to many biological processes. The findings of the Finnish scientists have implications to the study of cancer, evolution, development biology and many other areas of biology. The work revealed a potential mechanism explaining why many different genes are linked to cancer.


'"/>

Source:University of Helsinki


Related biology news :

1. Cracking the olfactory code in bees
2. Cracking the perception code
3. Cracking the egg
4. Cracking open the black box of autoimmune disease
5. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
6. Scientists detect probable genetic cause of some Parkinsons disease cases
7. Mouse brain tumors mimic those in human genetic disorder
8. Scientists identify genetic pathways essential to RNA interference
9. Researchers trace evolution to relatively simple genetic changes
10. Key mechanism in genetic inheritance during cell division identified
11. Scientists identify genetic pathways essential to RNA interference
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2016)... -- First quarter 2016:   , Revenues ... first quarter of 2015 The gross margin was 49% ... and the operating margin was 40% (-13) Earnings per ... from operations was SEK 249.9 M (21.2) , Outlook ... 7,000-8,500 M. The operating margin for 2016 is estimated ...
(Date:4/15/2016)... DUBLIN , April 15, 2016 ... of the,  "Global Gait Biometrics Market 2016-2020,"  report ... http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ,The global gait ... CAGR of 13.98% during the period 2016-2020. ... movement angles, which can be used to compute ...
(Date:3/29/2016)... , March 29, 2016 ... "Company") LegacyXChange "LEGX" and SelectaDNA/CSI Protect are pleased to ... ink used in a variety of writing instruments, ensuring ... of originally created collectibles from athletes on LegacyXChange will ... analysis of the DNA. Bill Bollander ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... Bangkok, Thailand (PRWEB) , ... May 25, 2016 ... ... the participation of a Thai delegation at BIO 2016 in San Francisco. Located ... private sector will be available to answer questions and discuss the Thai biotechnology ...
(Date:5/25/2016)... ... May 25, 2016 , ... WEDI, the nation’s leading authority on the use ... W. Stellar has been named by the WEDI Board of Directors as WEDI’s president ... executive leader with more than 35 years of experience in healthcare, association management and ...
(Date:5/24/2016)... La Jolla, CA (PRWEB) , ... May 24, 2016 , ... ... and financial planning for corporate executives and entrepreneurs, held The Future of San Diego ... leaders in the San Diego life science community attended the event with speakers Dr. ...
(Date:5/23/2016)... 23, 2016 Oxitec CEO Hadyn ... at 10:15 a.m. ET before the United States House Committee ... mosquitos can play in controlling the spread of the ... virus.      (Logo: http://photos.prnewswire.com/prnh/20150630/227348 ) ... a self-limiting gene. Trials in Brazil , ...
Breaking Biology Technology: