Navigation Links
Cracking the genetic code for control of gene expression

Molecular biologists, developmental biologists and computer scientists at the Universtity of Helsinki, Finland, came together to advance towards cracking the code for how gene expression is controlled. The results of this work are published in Cell, in January 2006.

A genome milestone was reached in 2001 when sequencing of the human genome was completed. This has been followed by complete chemical read-outs of DNA sequence for several species, for example mouse, dog, cow and chicken, in the recent years. But without a code or 'grammar' to reveal the message behind the sequence, the genomic DNA is merely a list of millions and millions of base pairs, A's, C's, G's and T's one after the other.

Based on the universal code by which DNA encodes amino acids, we can make sense of the constantly increasing amout of DNA sequence data as far as it encodes proteins. This code was solved in 1966 and it has allowed researchers to find new genes and estimate the total number of genes in the human genome. However, coding sequence covers only about 1.2% of the human genome. New codes and grammatical rules need to be resolved in order to understand the remaining 98.8% of the genome.

It is evident that genes are expressed in tightly controlled spatial and temporal patterns but we do not know the code by which the expression is regulated. In this post-genomic era, the next big goal is to decipher the genetic code of regulation of gene expression.

At the University of Helsinki the researchers have been interested in sequences which regulate gene expression. The research group, led by professor Jussi Taipale, Ph.D, has defined the binding specificities of several transcription factors. Transcription factors are DNA-binding proteins which are required to activate gene expression. In collaboration biologists and computer scientists designed a software called EEL (enhancer element locator) which searches genomic sequence for regions where many transcription factors bind DNA side by side. Finding the same region with high frequency of transcription factors in several species indicates that the DNA element regulates gene expression. The researchers showed that the predicted regulatory elements direct organ-specific expression of a marker gene in transgenic mice. Novel experimental and computational methods enabled genome-wide analysis of regulatory elements in several species.

Studying the control of gene expression is a growing area of research at the moment, likely owing to its fundamental importance to many biological processes. The findings of the Finnish scientists have implications to the study of cancer, evolution, development biology and many other areas of biology. The work revealed a potential mechanism explaining why many different genes are linked to cancer.


'"/>

Source:University of Helsinki


Related biology news :

1. Cracking the olfactory code in bees
2. Cracking the perception code
3. Cracking the egg
4. Cracking open the black box of autoimmune disease
5. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
6. Scientists detect probable genetic cause of some Parkinsons disease cases
7. Mouse brain tumors mimic those in human genetic disorder
8. Scientists identify genetic pathways essential to RNA interference
9. Researchers trace evolution to relatively simple genetic changes
10. Key mechanism in genetic inheritance during cell division identified
11. Scientists identify genetic pathways essential to RNA interference
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/31/2016)... R.I. , March 31, 2016  Genomics firm ... of founding CEO, Barrett Bready , M.D., who ... members of the original technical leadership team, including Chief ... President of Product Development, Steve Nurnberg and Vice President ... returned to the company. Dr. Bready served ...
(Date:3/23/2016)... March 23, 2016 ... Sicherheit Gesichts- und Stimmerkennung mit Passwörtern ... (NASDAQ: MESG ), ein führender Anbieter ... Unternehmen mit SpeechPro zusammenarbeitet, um erstmals dessen ... wird die Möglichkeit angeboten, im Rahmen mobiler ...
(Date:3/22/2016)... Ontario , PROVO and ... Newborn Screening Ontario (NSO), which operates the ... for molecular testing, and Tute Genomics and UNIConnect, ... management technology respectively, today announced the launch of a ... next-generation sequencing (NGS) testing panel. NSO ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of commercial spectrophotometers and fluorometers ... the 6000i models are higher end machines that use the more unconventional z-dimension of ... beam from the bottom of the cuvette holder. , FireflySci has developed several ...
(Date:6/23/2016)... 2016 /PRNewswire/ - FACIT has announced the creation ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" or "the ... a portfolio of first-in-class WDR5 inhibitors for the ... WDR5 represent an exciting class of therapies, possessing ... for cancer patients. Substantial advances have been achieved ...
(Date:6/23/2016)... 2016  The Biodesign Challenge (BDC), a university competition ... harness living systems and biotechnology, announced its winning teams ... New York City . The ... projects at MoMA,s Celeste Bartos Theater during the daylong ... senior curator of architecture and design, and Suzanne ...
(Date:6/23/2016)... Apellis Pharmaceuticals, Inc. today announced positive ... its complement C3 inhibitor, APL-2. The trials were ... studies designed to assess the safety, tolerability, pharmacokinetics ... healthy adult volunteers. Forty subjects were ... dose (ranging from 45 to 1,440mg) or repeated ...
Breaking Biology Technology: