Navigation Links
Cracking the genetic code for control of gene expression

Molecular biologists, developmental biologists and computer scientists at the Universtity of Helsinki, Finland, came together to advance towards cracking the code for how gene expression is controlled. The results of this work are published in Cell, in January 2006.

A genome milestone was reached in 2001 when sequencing of the human genome was completed. This has been followed by complete chemical read-outs of DNA sequence for several species, for example mouse, dog, cow and chicken, in the recent years. But without a code or 'grammar' to reveal the message behind the sequence, the genomic DNA is merely a list of millions and millions of base pairs, A's, C's, G's and T's one after the other.

Based on the universal code by which DNA encodes amino acids, we can make sense of the constantly increasing amout of DNA sequence data as far as it encodes proteins. This code was solved in 1966 and it has allowed researchers to find new genes and estimate the total number of genes in the human genome. However, coding sequence covers only about 1.2% of the human genome. New codes and grammatical rules need to be resolved in order to understand the remaining 98.8% of the genome.

It is evident that genes are expressed in tightly controlled spatial and temporal patterns but we do not know the code by which the expression is regulated. In this post-genomic era, the next big goal is to decipher the genetic code of regulation of gene expression.

At the University of Helsinki the researchers have been interested in sequences which regulate gene expression. The research group, led by professor Jussi Taipale, Ph.D, has defined the binding specificities of several transcription factors. Transcription factors are DNA-binding proteins which are required to activate gene expression. In collaboration biologists and computer scientists designed a software called EEL (enhancer element locator) which searches genomic sequence for regions where many transcription factors bind DNA side by side. Finding the same region with high frequency of transcription factors in several species indicates that the DNA element regulates gene expression. The researchers showed that the predicted regulatory elements direct organ-specific expression of a marker gene in transgenic mice. Novel experimental and computational methods enabled genome-wide analysis of regulatory elements in several species.

Studying the control of gene expression is a growing area of research at the moment, likely owing to its fundamental importance to many biological processes. The findings of the Finnish scientists have implications to the study of cancer, evolution, development biology and many other areas of biology. The work revealed a potential mechanism explaining why many different genes are linked to cancer.


'"/>

Source:University of Helsinki


Related biology news :

1. Cracking the olfactory code in bees
2. Cracking the perception code
3. Cracking the egg
4. Cracking open the black box of autoimmune disease
5. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
6. Scientists detect probable genetic cause of some Parkinsons disease cases
7. Mouse brain tumors mimic those in human genetic disorder
8. Scientists identify genetic pathways essential to RNA interference
9. Researchers trace evolution to relatively simple genetic changes
10. Key mechanism in genetic inheritance during cell division identified
11. Scientists identify genetic pathways essential to RNA interference
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/29/2016)... BOCA RATON, Florida , March 29, 2016 /PRNewswire/ ... ("LegacyXChange" or the "Company") LegacyXChange "LEGX" and SelectaDNA/CSI Protect ... Synthetic DNA in ink used in a variety of ... preventing theft. Buyers of originally created collectibles from athletes ... authenticity through forensic analysis of the DNA. ...
(Date:3/22/2016)... India , March 22, 2016 /PRNewswire/ ... market research report "Electronic Sensors Market for Consumer ... Proximity, & Others), Application (Communication & IT, ... Geography - Global Forecast to 2022", published ... industry is expected to reach USD 26.76 ...
(Date:3/21/2016)... Unique technology combines v ... security   Xura, Inc. ... digital communications services, today announced it is working alongside ... customers, particularly those in the Financial Services Sector, the ... within a mobile app, alongside, and in combination with, ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Rolf K. Hoffmann, former ... of the University of North Carolina Kenan-Flagler Business School effective June ... UNC Kenan-Flagler, with a focus on the school’s international efforts, leading classes and ...
(Date:6/24/2016)... ... 2016 , ... While the majority of commercial spectrophotometers and fluorometers use the ... models are higher end machines that use the more unconventional z-dimension of 20mm. ... the bottom of the cuvette holder. , FireflySci has developed several Agilent flow ...
(Date:6/23/2016)... /PRNewswire/ - FACIT has announced the creation of ... company, Propellon Therapeutics Inc. ("Propellon" or "the Company"), ... portfolio of first-in-class WDR5 inhibitors for the treatment ... represent an exciting class of therapies, possessing the ... cancer patients. Substantial advances have been achieved with ...
(Date:6/23/2016)... NEW YORK , June, 23, 2016  The ... students to envision new ways to harness living systems ... of Modern Art (MoMA) in New York ... more than 130 participating students, showcased projects at MoMA,s ... included Paola Antonelli , MoMA,s senior curator of ...
Breaking Biology Technology: