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Cord blood cells may widen treatment window for stroke

stroke. What's more, the treatment can be delivered much later than the current strict three-hour therapeutic window."

The USF study challenges the notion that nerve cells inevitably die quickly in the core region of the brain most severely deprived of oxygen and nutrients when a stroke hits. Instead, the researchers suggest, many nerve cells within ground zero of the attack, like those in mild to moderately damaged outlying areas, may succumb over several days through a slower, more orderly process known as apoptosis, or programmed cell death.

"This delayed death would permit more time to deliver neuron-sparing treatments than originally thought," Dr. Willing said.

The USF researchers continue to investigate the ways cord blood cells aid stroke recovery in animals, and will begin a study to determine the timing of brain inflammatory responses in acute stroke patients.

Researchers working with Dr. Willing were Jennifer Newcomb, Ted Ajmo, Lisa Collier, Cyndy Davis Sanberg, PhD; Keith Pennypacker, PhD; and Paul R. Sanberg, PhD, DSc. The USF study was conducted with Saneron CCEL Therapeutics, a USF-spinout biotechnology company developing cell therapies for deadly and debilitating disorders. Dr. Sanberg is a cofounder of Saneron CCEL, and Dr. Willing is a consultant.


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Source:University of South Florida Health


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